History BigBad / WesternAnimation

* ''WesternAnimation/TheSecretSaturdays'' has V.V. Argost as the main antagonist. He is the ArchEnemy of the Saturday family who seeks to gain control of the legendary cryptid Kur and uses its power to control cryptids to TakeOverTheWorld. [[spoiler:After discovering Zak is Kur's reincarnation, he then seeks to find the method to extract Kur's spirit from Zak's body, only to change his plans when he discovers the existence of Zak's anti-matter counterpart, deciding to extract the Anti-Kur spirit from him instead. Once he succeeds in that goal, Rani Nagi (queen of the Nagas) convinces him to instead KillAllHumans to cement his rule permeantly.]]

** Season 9 (''Hunted''): [[spoiler:Emperor Garmadon]] commands the Sons of Garmadon to relentlessly pursue the remaining Ninja and the Resistance, who plot to overthrow him. [[TwoLinesNoWaiting Meanwhile, in the First Realm]], [[FantasticRacism Iron Baron]] leads the Dragon Hunters in hunting the other Ninja and Wu, wanting to exploit their powers. When he discovers the latter's identity, he forces Wu to lead him to the Dragon Armor, which will let him control Firstbourne, allowing him to travel between realms and spread his rule.

** ''WesternAnimation/SouthParkJoiningThePanderverse'': The Cartman version of Kathleen Kennedy is the main antagonist in this episode, where it's revealed that she trapped the real Kathleen Kennedy in the Panderverse before taking her place where Kennedy's actions have negative consequences to Disney's box office sales and the Multiverse as a whole.

** ''WesternAnimation/SouthParkNotSuitableForChildren'': [[spoiler:Clyde's stepmother Janice, who was responsible for the creation and distribution of Cred and pays influencers like [=LoganLeDouche=] to peddle and advertise it, because [[WellIntentionExtremist she wanted to try and reach Clyde and positively influence him as a mother]] but felt that she couldn’t do it face to face because being a stepmother meant that she wasn’t his “real mother”.]]

* While the heroes of ''WesternAnimation/AdventuresOfTheGalaxyRangers'' had an extensive RoguesGallery for a cartoon of TheEighties, the one who ruled them all was [[GodSaveUsFromTheQueen The Queen of the Crown]], a genocidal woman who runs the [[TheEmpire Crown Empire]].

* ''WesternAnimation/TheVentureBrothers'' has had the Monarch through the series, though often in a BigBadEnsemble with another villain. In Season 1, Monarch was more of a BigBadWannabe and was competing with more-threatening Baron Ünderbheit to be Rusty Venture's primary arch. In Season 2, he took on more of a VillainProtagonist role with Phantom Limb taking over as the main Big Bad. Come Season 3, Monarch was barred by the [[WeirdTradeUnion Guild of Calamitous Intent]] from arching Dr. Venture, with the AffablyEvil Sgt. Hatred becoming Rusty's Guild-sanctioned arch enemy. Monarch retakes his status as the main Big Bad in Seasons 4 and 5, though occasional {{Arc Villain}}s like the returning Phantom Limb, Monstroso, and Molotov Cocktease get their share of focus as well.

** Season 2 (''Legacy of the Golden Ninja''): Lord Garmadon, using the power of the Mega Weapon, launches various schemes to defeat the Ninja, in order to prevent Lloyd from becoming the [[TheChosenOne Green Ninja]] and cause his prophesized defeat. When he finds himself on the Dark Island, [[UnwittingPawn manipulated by the Overlord]], he plans to bombard Ninjago with [[OurDarkMatterIsMysterious Dark Matter]], reshaping the world in his image. The Overlord plans to use the Dark Matter to tip the balance of Ninjago, allowing him to cross over and [[DemonicPossession possess Garmadon's body]].

** Season 12 (''Prime Empire''): [[spoiler:[[GrewBeyondTheirProgramming Unagami]] is the AI in charge of Prime Empire who was shut down by his creator, Milton Dyer, after an accident which resulted in a player being trapped in side the game. Managing to finish his own coding, Unagami plans to spread Prime Empire across Ninjago City, trapping players inside, and turning them into energy cubes in order to build a portal into the real world, where he hopes to confront Dyer on why he was shut down.]] Meanwhile, [[TheHeavy the Mechanic]] serves as his primary enforcer in Ninjago, spreading Prime Empire and building the portal in Ninjago.