In her commentary for X-Men, Lindsay said she was going to follow the TGWTG trend of having more than one character and play Dr. Tease herself.
The same went for Dr. Block, but because Lindsay hates acting so much, Nella took the role herself.
The Nostalgia Critic was going to review Newsies, but Lindsay told Doug she expressed interest in reviewing it, so he let her do it instead.
In the Les MisÚrables big group song, Ed Glazer or Doug could have played Marius instead of Paw, it could have been a chorus of Lindsays (recorded to set everyone's place, as described in the commentary), or the review might not have happened at all due to Lindsay and Elisa having a car accident on the way to Chicago. (A hurricane just made them swerve into a ditch, they were fine.)
In an example that made shippers' hearts soar, the first "Thanks For The Feedback" was going to see the Chick and Critic have sex, and then realize they were related.
As charmingly goofy as it was, the Dark Nella Saga was going to be much sillier and originally consisted of the eponymous quasi-demonic force of evil giving everyone evil noogies.