Irony as She Is Cast: Kyle has never had a song to himself in the series; his voice actor, Jamie Kennedy, is a professional singer.
Keep Circulating the Tapes: Only two DV Ds were released, and the entire first season was available to order on Amazon. The show has recently been taken off the air; if you happen to have a recording of either episode saved (especially the entirety of the second season), then do not erase it.
Playing Against Type: Josh Duhamel, who usually plays badasses in live action, does the voice for Oz.
Release Date Change: The episodes "Risky Business", "Kids in the Hall", "Crib Notes" and "Hypnot O Zed" were going to air on August 6, 2011, but were delayed at the last minute to August 27.
"There Will Be Shrieks" was going to air on October 22, but was pushed forward one day later to make room for a Sponge Bob Squarepants rerun.
Screwed by the Network: The biggest example yet. Originally Adored by the Network in 2009-2010, the second season had its episodes delayed for quite a long time. It took four years - with no episodes throughout most of 2012 and all of 2013. In addition, no third season was announced, canceling the show all together.
Talking to Himself: Jeff Bennett does the voices of many recurring characters, including Boog and Agent Johnson, who argue with each other in "A Bopwork Orange". He also voices Man-Arctica and his Arch-Enemy, the Global Warmer.
Throw It In!: Kyle's line "The Great Griffon!!" in "Wizboy" when he spots the great griffon flying through the air was not in the original script. It was ad-libbed by Jamie Kennedy last minute.
Unintentional Period Piece: Though generally averted, the episode "Bubble Trouble" comes to mind in light of Billy Mitchell being exposed for cheating on Donkey Kong in early 2018.
The Pilot Episode "Wizboy" was to have a scene in the hallway right before the lunch scene; also, some dialogues were longer.
For "Pick a Nose", the boys' preparation scene was longer, such as Fanboy painting his head. Also, the boys originally got dirty by crawling in a dumpster, while in the episode, they repeatedly sniff a dirty Chuggy.
Two scenes in "Trading Day", one involving Yo sneaking away with Chum Chum in her mouth and Kyle with his own Mechatech. These were removed for an unknown reason, but can be seen in the novelization.
The episode "I, Fanbot" had an alternate opening where the boys watch Kyle make a potion with his Lil' Warlock Kit, and Fanboy is caught drinking from it before burping up a smoke skull (Which explains why Kyle is sitting between the boys in the first shot). This was removed in the final version as it was deemed too harsh and unsettling, and skipped to the scene where Mr. Mufflin announces the test, and Fanboy is caught making a weird face instead.
Originally, Oz removed Fanboy's brain first; in the episode, he takes out the robot's brain first. Also, the robot didn't speak originally, he was given a voice near the end of production.
There was an extra scene involving the three boys giving out a note in the hallway in the script and storyboard for "Excuse Me".
"Present Not Accounted For" originally had Dollarnator giving Chum Chum a joke-of-the-day calender; in the final episode, he had no lines, and his gift remained unknown. Also, Kyle's dramatic monologue originally started right when he was introduced, and was a little different.
The Halloween Episode "There Will Be Shrieks" was originally going to end with the boys not getting their taste back, and Chum Chum's grapes from earlier falling out of the sky into his bowl.
Kyle's first scene in said episode is much different in the storyboard than the episode. In the storyboard, he is sitting at a desk reading from a book; in the episode, he grabs a book off the bookshelf to read it.