Jessica Walter, Judy Greer and Jeffrey Tambor, with similar traits to their AD characters (especially Jessica Walter as Mallory, which can best be described as "Lucille if she were a cartoon character"). Add this to the numerous Running Gag and cut-based gags, and this show is pretty much a partial Arrested Development reunion show (at least until the new, Netflix-streamed episodes premiered).
Real-Life Relative: Malory's new husband, Ron Cadillac, is played by Ron Leibman, Jassica Walter's real life husband.
Most characters, such as Archer and Lana, were based on Atlanta-area models, while Brett and Len Trexler were based on their voice actors, Neil Holman (also the art director) and Jeffrey Tambor. Lana, by sheer coincidence, looks strikingly like Aisha Tyler. Mallory was designed with her voice actress (Jessica Walter) in mind, but is actually based on a model with a more "extreme" look. Finally, Ray is an interesting aversion of the Ink-Suit Actor: while his design is based on a member of the cast, his model is Lucky Yates - the voice of Krieger.
Additionally, while there's no indication it was intentional, Cyril◊ looks alarmingly like serial killer Robert Hansen◊ (with a little bit of his voice actor, Chris Parnell), though he was actually based on a friend of Adam Reed.
What Could Have Been: Before Judy Greer auditioned for the role, Adam Reed planned to write Cheryl out of the show in Season 1, as part of a running gag where Archer kept getting ISIS' secretaries pregnant. 1
The show was originally titled "Duchess".
Amber Nash, voice of Pam, is neighbours with the physical model of Pam.