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Tear Jerker: Beetle Juice
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When the Maitlands are being exorcised, it can bring a tear to the eye.
When the Maitlands realize they are dead is pretty teary.
The Animated Series
In "Doomie's Romance," The failed attempt at bringing Pinkie (the Mayor's former car) to life causes Doomie to sob uncontrollably. It brings Lydia to tears, but when Doomie's tears brink Pinkie to life, it brings B.J. to get emotional as well (though he wouldn't admit it).