- Peanuts
- In one strip, Charlie Brown is watching Shane on TV, and laments that Shane never comes back.
- In another strip, Snoopy thanks Woodstock for admiring his hat, and then tells Woodstock to stop shouting, "Come back, Shane!"
- Yu-Gi-Oh! 5Ds A Live: Sundown Kid reveals that his first name is Shane.
- Logan has Charles Xavier and Laura watching Shane at the hotel, where by that time (2023), the movie is 70 years old. They notably watch the scene where Shane tells Joey that "There are no more guns in the valley.", which Laura recites at the end of the movie as a eulogy for Logan.
- The Man with the Golden Gun: The duel between Bond and Scaramanga was inspired by the duel between Shane and Wilson.
- Nowhere to Run has Jean-Claude Van Damme play an updated version of Shane, trying to protect a single mother (Rosanna Arquette) from an evil developer (Joss Ackland).
- Both The Parallax View and The Departed have a scene in a bar where the main character (played by Warren Beatty in the former and Leonardo Dicaprio in the latter) is harassed into a fight because he orders something other than an alcoholic beverage (milk in the former, cranberry juice in the latter).
- In The Negotiator, the hostage negotiators played by Samuel L. Jackson and Kevin Spacey get into a discussion as to whether Shane lived at the end.
- One of the villains in Batman (1966) is a cowboy-themed ne'er-do-well named Shame. And of course there's another kid shouting That Line.
- Gilmore Girls: In the season three episode "Haunted Leg", Jess mentions he has a girlfriend named Shane.
- The Star Trek: The Next Generation episode "A Fistful Of Datas" recreates one of the final shots from the film, when Alexander Rozhenko is peeking out from under the saloon doors.
Music
- The music video for "5:01AM (The Pros and Cons of Hitch Hiking, Part 10)" by Roger Waters features clips from the film.
- Bill Hicks had a bit where he compared America's bullying of weaker countries to the confrontation between Wilson and Torrey, including a one-man reenactment of the scene.
- One of the endings to the infamous CDTV game The Town with No Name has a kid yell "Come back, Shane!" as the player character goes back on the train as soon as he arrives and the guy shoots the kid, claiming that "My name's not Shane, kid" before the train flies off into space.
- Hark! A Vagrant did a comic
about the ending of Shane, where Joey decides to call for Shane...as in on a cell phone. Kate Beaton also concludes that 'Marian should have hit that'.
- One of the interchangeable lines in the opening theme song of Animaniacs is "Come back, Shane-y".
- Avatar: The Last Airbender: According to Word of God, the episode "Zuko Alone" is a Whole-Plot Reference to Shane but with a dark twist at the end.
- Rocko's Modern Life: "Junk Junkies" features a scene where Heffer and Wallace, a goon from the pizza company try to intimidate each other as Rocko argues with the delivery driver.
