Omega-xis: Well if it makes me strong, it's my kind of curse.

It's not a curse, Phil. It just depends on how you look at it.

"Sometimes at night, while everyone else sleeps, Cyclops wanders the X-Mansion to loudly fuss about how his eyes shoot lasers. We’re real sorry your blasted energy-blasting head does something so awesome, buddy."

"'Boo hoo, I can fly!' That’s you.”

Jeong Jeong: Water brings healing and life. But fire brings only destruction and pain. It forces those of us burdened with its care to walk a razor's edge between humanity and savagery. Eventually we are torn apart.

Buffy: But you're right. I mean, like... I guess everyone's alone, but... being a Slayer? There's a burden we can't share.
Faith: And no one else can feel it.... Thank God we're hot chicks with superpowers.
Buffy: That does take the edge off.

— Buffy the Vampire Slayer, "End of Days"

Darcy: I'm speaking from experience... I appreciate the offer, but I really don't need any friends...

GG: Boohoohoo look at the torment I feel. The Torment of being an incredibly cool personification that also happens to look like an attractive woman. Boohoo. My life is soooo horrible.

(GG resumes his normal voice)

GG: Seriously, there are far worse fates you could have received.

— We Are Our Avatars

...instead of infecting Ryu with a sensible, terminal illness, they infect him with a magical curse that makes his arm go all weird and gives him the ability to go banana-nut-butters and instantly slaughter a bunch of dudes berserk-style. ...Wait, that's not a curse at all!

Tony Stark: You know, I've got a cluster of shrapnel trying every second to crawl its way into my heart. This stops it, this little circle of light. It's part of me now, not just armour. It's a terrible privilege.
Bruce Banner: But you can control it.
Tony Stark: Because I learned how.