The SIC, having discovered that the otherworldly creatures are indeed horrifying and incomprehensibly evil, decides that humanity itself must become a similar entity in order to survive. However, upon doing so, the humanity-abomination realizes that there are always even bigger fish in the sea that the 'Horrifying monsters' seem like helpless little humans compared to.
Justified: The immense size and complexity of the universe, the limitations and conflicts of human existence, the existence of an infinity of other multiverses, and the Second Law of Thermodynamics, justifies almost everything about the Cosmic Horror Story.
Humanity comes across an Eldritch Abomination, or one such arrives in Earth's dimension. However, while they find it strange-looking, certainly, that's it. No mind-shattering horror to be found here.
Double Subverted: ...and then it turns out that it was an act, and they really are inhumanly evil.
Parodied: The tentacle beast is named "Coco", and is just a bigger monster's pet.
Zig Zagged: A main character, very fearful of being attacked by an Eldritch Abomination, sights a tentacle in the forest, but it was just someone elses costume, then he sights an actual real tentacle, which grabs him. Only it was a dream and he's just letting paranoia get to him... or is he?
Averted: There are no Lovecraftian horrors in the world.
Defied: The SIC finds that the Earth is filled with monstrous creatures of mind-warping horror - and they absolutely refuse to let this be one of those cosmic horror stories where humans are unimportant.
Conversed: "Due to the immense size of the universe, it's possible for other creatures to evolve beyond our comprehension".
Everyone realizes how insignificant they are. They all become Straw Nihilists and/or commit suicide. Thus, no story.
Alternately: The premise is that Humans are insignificant to these creatures, which means they'd never bother with a small hunk of rock floating close around one in a zillion stars. What wouldn't bother causing humanity trouble.
In a more positive deconstruction: In Real Life cosmology there really are things out there so enormous, so powerful and so mind-shatteringly complex that our entire world is meaninglessly small in comparison, but we just don't care like how they don't care about us. Also, the existential horror of insignificance isn't that horrifying, being pretty easy to ignore.
So this kind of story basically fosters a Darkness-Induced Audience Apathy mentality.... but as a response, while the unstoppable horrors are still present, the protagonists are at the very least given some Character Development, with exploring the psychology and meaning of their existential crisis before the inevitable doom. Sometimes works and makes the characters more sympathetic than a bunch of ants, sometimes doesn't.
Alternatively, while the unstoppable horrors are still present, there's also a force out there does care for the well-being of humans, even if it doesn't directly interact with them, and thus holds the greater horrors that threaten humanity on a cosmic scale at bay, leaving the humans to having to deal with the lesser horrors that threaten them on a more direct, personal scale.
The tentacle monsters take one look at the nearest human, and either jumps screaming onto the local equivalent of a chair, briefly looks shocked and squishes him, or traps him under a jar and a sheet of paper and deposits him outside, like they've seen a spider.