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Anime and Manga
- Batman: Bruce had a bit of an...extreme reaction to Dick going off to college. It involved moping around in Dick's room, contemplating changing his Batsuit, and closing up Wayne Manor to move to an apartment in Gotham. In addition to that, Bruce once admitted to taking in Jason because he was lonely and missed Dick. He's very attached to his eldest son.
Films — Animated
- An Extremely Goofy Movie has Goofy suffering from this bad. He's so distracted by his son, Max, leaving for college that he ends up fired from his job, and has to go back to school to get a degree to get a better job... the same school Max is attending. Once there, Goofy promptly keeps trying to baby Max, losing focus on his studies, something he warned Max to avoid.
Films — Live-Action
- Accepted: The bulk of the film (90%) is about the kids at college, but the parents demonstrate Empty Nest.
- Spanglish: The mom is all about her little girl; she even has trouble with her daughter going to a different, far(ther) away high school''.
- Father of the Bride (1950) and the remake are all about this, but with the daughter getting married rather than going to college.
- Film/hristmasWithTheKranks: Their kid is gone, they decide to have a little "us" time. They then go to hell for being selfish.
- Bill Bryson described what happened when his son left for college in Im A Stranger Here Myself. He would see something and start crying. His wife just cried indiscriminately.
- Cindy from Hollow Places bears a great deal of shame for having to kick her eldest foster child, Austin, out of her house due to budgetary reasons. It's made clear throughout the novel that she truly misses him.
- In The Dresden Files: Skin Game, the Greek god Hades tells Harry that Demeter made up the myth about him abducting Persephone due to empty nest syndrome; their marriage was actually a love match.
- The Golden Girls: The girls have some neighbors at one point suffering from Empty Nest syndrome hard. This was retooled, revamped, and spun off into...
- Empty Nest, the TV show, which inverts the entire concept—A show about a guy whose wife dies and then his adult daughters move in with him.
- Cougar Town: Jules is a bag full of crazy whose life centers on her son. Bobby gets it, too.
- Firefly: Did Simon get Empty Nest over River going to the Academy, or was it just that she was being systematically tortured and Mind Raped, able to communicate only in code?
- Samurai Sentai Shinkenger: After the vassals leave at the end to pursue their own destinies, Jii, the mentor and father figure of the group, looks around the main gathering room and sadly asks, "Was this room always so spacious?"
- Bill Engvall talks about dealing with this trope in his stand-up special Aged And Confused. Specifically, about how his wife is constantly driving him crazy now that the kids are gone.
- In this College Humor sketch, a young man returns home for Thanksgiving, only to find that his parents have started feuds with neighbors they previously liked, taken up unusual hobbies, redecorated several times over, put up a Room Full of Crazy's worth of photos of him, and taken in foreign exchange students because they just can't cope without him.