Tony: If I get anthrax, how will you feel?
Gibbs: Not as bad as you, Di Nozzo.One of the best ways to assure that people pay attention is to endanger a character they love. Sometimes, writers need to be able to put characters in a situation that could potentially result in the apparently impending death of multiple characters, but where they can be in a relatively peaceful environment and where death will take a while to befall them. This allows time for Angst and Character Development. Enter the Contamination Situation, in which a main character is exposed to or infected with something very bad, usually potentially fatal and the exposure/infection is a main focus of the episode. In television, unless a character experiences a near-death revelation that completely changes them or dies, these episodes are typically not Wham Episodes, but are still usually a big deal. In most cases, we're talking about November/ May sweeps episodes, not season finales. The infection usually advances Character Development by causing the character to rethink their life. If one of the characters caught up in the ordeal is part of a Will They or Won't They? storyline, you can expect that relationship to take a front seat when this happens. This can result in a Crowning Moment of Heartwarming or, in the best-case scenerio, a Love Epiphany. Other characters may also have poignant conversations about the fragility of life. In television, this is most prevelant on crime and medical dramas, not surprisingly. The exposure/infection usually, but not always, happens to a leading character as opposed to a supporting character. If it is a suppoorting character, it will probably be Everyone's Baby Sister. The goal is for the audience to be emotionally invested, so more often than not, the infected character is a fan favorite. There are also countless films based on this premise.
— NCIS, "S.W.A.K."
All Spoilers will be unmarked ahead. Beware.
- In Contagion, Matt Damonís character is infected with a virus, but is immune to it. Later on, one of the main characters has been infected with a virus and uses this to test the cure. Another main character dies from it.
- In The Last Man on Earth, Vincent Price is the only person left and is immune to the virus turning people into vampires, but does have the virus.
- In I Am Legend, the dog is infected with a virus that turns him into one of the mutants. Robert Neville has to kill his dog.
- In 28 Days Later, one of the main charactersí friends is infected, and she must kill him.
- In The Cassandra Crossing, one of the main characters, a doctor, is infected with a virus and is considered to be an engineered biological weapon.
- In Airplane! the mysterious sickness gets both the pilot and copilot.
- In the film Outbreak, Rene Russo and Kevin Spacey's characters both contract the deadly Motaba virus. One of them lives long enough to get the cure. It is, unfortunately, not Kevin Spacey.
- This is extraordinarily common in zombie movies, and not just to people who refuse to tell anyone. Perhaps the ur-example is Roger in Dawn of the Dead (1978) (Karen Cooper was in a similar condition in Night of the Living Dead (1968), but in that example, neither the audience nor the characters knew that a bite always means death). Roger's infection leads to a poignant moment in which he promises to "try...not to...come back."
- In Aunt Dimity and the Lost Prince, Lady Barbara Booker relates how her childhood friend left his stuffed bear at her house the day before he came down with polio (this was in the 1920s, decades before any vaccine). She innocently tried to visit Mikhail to return the bear, and her father "went spare" and gave her a severe spanking. Although she was kept informed of his progress in recovery, "Basha" and "Misha" did not see one another again until Lori ad Bree's investigation prompted Barbara to pay an unannounced visit to Mikhail's family home.
- House had three: "Euphoria" in season two, where Foreman is infected from a patient, "Airborne" in season three, where House and Cuddy are on a plane with someone who is suspected to have meningitis, and Cuddy thinks she has it, and "A Pox on Our House" in season seven, where House is exposed to an contagious patient.
- Bones had one in season one ("The Man in the Fallout Shelter"). The entire team is exposed to an infectious body.
- Cam and Arastoo have each been exposed individually in different episodes.
- Fringe did theirs in season two. Peter contracts a pathogen at a crime scene.
- In an episode in season one, Charlie becomes an incubator for a supernatural creature.
- On 24, after Jack contracts a pathogen from a bio-weapon, the entire second half of the seventh season is a string of contamination episodes.
- The penultimate episode of the second season of NCIS, "SWAK", centered around Tony and Kate's exposure to the pneumonic plague, which was sent to the team in an envelope.
- In the late season four episode "Amplification" of Criminal Minds, Reid is exposed to anthrax by a serial killer.
- In the season four episode of Psych, "Death is in the Air", a deadly virus is stolen and released on a public place, Shawn then discovers that its part of a Poison-and-Cure Gambit from the company that makes the cure for the virus, as it was about to be closed down because the government didn't think the virus was a threat enough to fund the cure. The culprit dies before he can release more of the virus, since the cure dosage needed wasn more than he anticipated, but then Juliet gets infected with the virus when recovering the last batch, so they have to race to the culprit's hiding place for the rest of the cure before she succumbs.
- In an episode of Sliders, one of Quinn's friends gets the plague.
- In Helix, the series begins in the immediate aftermath of Dr. Peter Farragut's infection with a Synthetic Plague, turning him into Patient Zero and the ensemble's Tragic Monster, a carrier of The Virus who spreads it throughout the Research, Inc. where he works. The CDC rapid response team includes his brother Alan and his ex-lover Julia, both of whom want to see him saved despite interpersonal tensions and shared estrangement. Peter soon infects Julia, and she in turn, has to cope with realizing her fate and being the sole CDC member in quarantine with other infected.
- Emergency! had one. John Gage and Dr.Brackett are both infected with a deadly monkey-transmitted flu. Another fireman dies, but the discovery of a person who fought off the virus saves the main characters.
- On Agents of S.H.I.E.L.D., in the November sweeps episode "F.Z.Z.T.", Simmons is infected with a virus carried by Loki's soldiers that will eventually cause her to explode, taking the entire plane (and all the other characters) down with her. After apparently failing to develop an anti-serum, she jumps from the plane in, what is intended to be a Heroic Sacrifice.
- The first few episodes of the fourth season of The Walking Dead have a deadly flu epidemic in the prison. Glenn and Sasha are among the characters infected, and Hershel is in the quarantine cell block tending to the sick. The Zombie Apocalypse adds another complication, as if those who die from the epidemic aren't dealt with, they come back, and not in the good way. It comes to a head in the fifth episode, "Internment," where a bunch of the supporting characters die and Glenn is barely saved.
- In a two-part episode of Castle, he is exposed to a toxin after shadowing Beckett on a case in D.C. The two had recently become engaged, so the shipping aspect was there, but it mostly served to allow him to work with her despite no longer being under Mayor Welton's discretion (Well, he's dying anyway, might as well let him feel useful).
- Used many times in early episodes of The X-Files.
- In Futurama, Fry has a dormant 20th C. strain of the common cold, which had been eradicated centuries earlier. It leads to the entire island of Manhattan being quarantined and then launched to the sun for good measure.
- In Resident Evil 3, Jill Valentine becomes infected with the T-Virus. It makes her so ill that a second character becomes playable, and it is he who finds a cure.
- In The Last of Us, two important characters become fatally infected with Cordyceps. Sam pulls the usual schtick; the other reveals her bite in a bid to guilt Joel into doing what she believes is right.