The World of Darkness: There are all sorts of of human/non-human goings-on in both settings, including vampires and werewolves. Most splats are non-human in some way, except Hunters and Mages, and most of them can mate and even reproduce with humans under at least some circumstances. The only ones truly unable to do so are Wraiths, being wholly immaterial. Indeed just about every supernatural engaged in romance with humans, even the vampires (though less so due to their deadness). Generally the likelihood of said romances are similar between the two versions of a given splat:
Vampires are living corpses — although they can have sex if they choose, their sex drive is mostly so dead they're hardly ever in the mood — as are Prometheans, so they're sterile to begin with. Bizarrely, in the Old World of Darkness there were very unusual circumstances in which vampires and kuei-jin could actually have half-human offspring, but this was far from the norm.
Even though Prometheans are sterile, it may happen occasionally that one finds themselves a parent. These children are known as Scions, and they're both able to sense when a Promethean draws near and unaffected by Disquiet.
Werewolves only hit lycanthrope status at puberty (though no one would ever consider trying to have sex with a werewolf in its War-Form...unless they were pretty much invincible or into self-snuff and that got creepy really fast). In Werewolf: The Apocalypse all the shapeshifters have families, including animal and in most cases also human Kinfolk who are, in almost all ways, entirely normal. Most shapeshifter-shapeshifter pairings inevitably produce either a sterile and deformed Metis or no child at all, and even the Changing Breeds with fertile "Metis" can never produce enough to maintain their population without breeding with humans and their animal species. (Some Garou have speculated that Gaia designed them that way deliberately, to prevent them from ignoring the people they should be protecting.)
Very early fluff hinted the Ultramarines have an human/Eldar hybrid among their number, though this is somewhat undermined by that same fluff also stating that Eldar have, among other horrendous biological impossibilities, zero body fat (but for some reason the females still have rather prominent breasts) and TRIPLE HELIX DNA. Like most things from the early fluff, this has been stricken from the collective fandom consciousness.
Genestealers combine this trope with Face Full of Alien Wing-Wong, a sub-species of Tyranid that focus on infiltrating target populations. They do this by changing a target's DNA slightly, making the target absolutely devoted to the Genestealer and Tyranids in general, and horny. Any child of the targeted creature (known as a Brood Brother) is less of the parent race and more Tyranid, until by the fourth generation Brood Brothers (well, Sisters) give birth to purestrain Genestealers.
One straight example however is the fanfic Love Can Bloom which deals with the Eldar Farseer Taldeer of Ultwhe and her lover, a Vindicare Assasin designated LIIVI who spared her life and then got involved with her. Later they have a child named Lofn. As of Dark Heresy, the story is canon.
If it exists and can have sex, then some Exalted has had sex with it. The Lunars above all, that's how Beastmen came to be. If it makes a difference, the Lunars have the ability and usually the inclination to ask animals first, and shapeshift into the same species. Beastmen, for the record, are usually conceived when a Lunar and a human or a Lunar and an animal mate in a Wyld bordermarch... with the Lunar in a form different from their mate. (Geoff C. Grabowski once defended the Lunars' predilections by pointing them to Werewolf: The Apocalypse with the words "F—k This Wolf Or The Earth Will Die". (Direct quote.))
The game has rules for various types of "God-Blooded," beings with one normal mortal parent and one Exalted or non-human parent. That parent may be an Exalt, a faerie, demon, a god, an elemental, or even a ghost. Sex, let alone breeding with, anything besides a Dragon-Blood is taboo in Realm culture, and interspecies pairings are frowned upon by the Celestial Bureaucracy and many other cultures. But plenty of gods give the finger to their superiors and plenty of cultists like to summon demons for disturbing uses. For ghosts, reproduction requires an obscure and hard-to-learn power. Gods, Lunars, faeries, demon-worshippers, and Deathlords all value God-Blooded as useful minions (or slaves) with a measure of their parents' abilities but not nearly enough power to pose any threat to their creator or owner. They may also lack their non-human parents' frailties, such as Fae-blooded and Half-demons who can live in Creation indefinitely without problems. Lunars also like to spawn whole armies of Beastmen, since their own numbers are so limited.
Interestingly, some God-Blooded are born to parents who subvert this trope; some gods have ways of reproducing that don't involve anything remotely resembling sex, especially those with totally non-human anatomy. If you get pregnant from inhaling magic pollen, does it really count as romance?