In issue 22, Supergirl meets Cyborg Superman while on another planet. He acts very friendly to her and offers a way to make her memories of Krypton come true. When he tells her what he wants for the offer, she retorts:
Supergirl: You want to say that again? I couldn't hear you through all the creepiness coming out of your mouth!
Sanctuary's reaction to the two Karas - Supergirl and Power Girl - is to try and kill one or the other. While this isn't intrinsically funny, it's the way it's written, with both Kara's being mostly just exasperated with Sanctuary, who proves to be something of a Deadpan Snarker.