For an example only available online, Brad messing with Chip in a game of Reverse. "My Lord is asleep right now, but he gave the the right to take all the messages from you." Props to Chip's hilarious accent.
Poor Jeff— it's been at least two times that he's been stuck in freeze-tag in a "promising" position (downward dog and on his hands and knees, respectively) without being tagged for most of the game... but it was absolutely hilarious when he ended the game himself, after getting sick of not being tagged out, and simply walking away.
This game of Freeze gives us Jonathan as a seal playing the Flight of the Bumblebees. Also a good reason why Ryan doesn't go to that many parties. Including a take that to the MGN!
Also from that video, a rip on the TSA that doesn't stop ripping:
Heather: I'm just gonna pat you down. (her hands unfortunately reach momentarily for Jonathan's pants) Jonathan: Whoa... Heather: All right... I am going to check this area... then I will ch...
Drew: Freeze! (replaces Jonathan as the Friskee with a lewd expression)
Heather: (is stunned for a bit) Ryan: Freeze. (he replaces Heather... then Drew is replaced by Jeff... then Drew re-joins Jeff, and Jonathan joins them all in front of Ryan...)
From the episode with Wayne Brady:
Johnathan: (Gruff voice) I think you should do it, Wayne! Walk up to her, ask her out!
Ryan: (Equally gruff voice) No! No Wayne, let her go! She's not right for you!
Johnathan: Why don't you sound like an angel?
Ryan: Oh, sorry! (gentler voice) No Wayne. I didn't see the... (motions to Johnathan's "horns")
(Audience member Jen is struggling to move Chip, as she continually forgets to move his legs.) Chip: "I'm going to walk over to my tennis bag and get it. (Jen turns him around using his arms.) With my leeeeegs." (After Chip gets his "racket," Jen again struggles to turn him around using his wrists, resulting in Chip starting to tip backwards. Trying to keep her balance, she spreads his arms wider.) Chip, leaning backwards, arms outstretched: "WHASSUP, TOM?! I'M 'BOUT TO GET MY TENNIS ON!"
Same episode, also from Moving People:
Chip: I'm going to charge the net! (Jen, trying to make Chip charge the net, causes him to instead fall face-down)
In episode 18, Drew and Kathy, an audience member, kept making suggestive motions to each other. Ryan came up behind Drew and rubbed Drew's ass, who assumed it was Kathy's hand. He turned around and saw it was Ryan, derailing the game before it even started.
While "Youwear my eye!" wasn't spectacular in and of itself, Ryan turning and refusing to change what he said in New Choice was hilarious. "No, I like that one!", indeed.
Greg, as Elvis Costello: Well, let's take a look at this baby. Oh, look at that, it's a baby! (New choice) Oh, look at that, it's two babies! (New choice) Oh, look at that, it's not a baby! (New choice) What the hell is this? (New choice) That's not a baby, it's a doll! (New choice) That's not a doll, it's a baby! (New choice) (Beat) Wanna dance?
Jeff: Same choice but in the Elvis Costello accent.
"New Choice" from episode 19:
Greg: Did you ever really know me? Ryan: I don't know. Greg: If you knew me, you'd know that I wanted to be a writer. And that I didn't want to handle organs all day, especially your organ. I had to search for it all night. Ryan: (putting his hand on Greg's shoulder) New choice.
Episode 2: Colin's accent, the ant song, and Shakespeare stand out.
The other cast members picking up Drew and Kathy so that they can jump kick each other.
Jeff being stuck with twelve word sentences in a game of Options, and saying "Sucker!" in a Shakespearean accent.
Colin's response to the "horror" genre: he gripped his hair so that it stuck straight up from his head in a parody of old monster movies, bugged one eye out, and stalked after Drew, finally yelling "DO YOU LIKE THE HAIR NOW?!" while Drew let loose a bunch of shrill yells. Made even better when Colin laughs under his breath, "I think I hurt myself..."
Drew pulls a Colin in a game of "Options".
Drew: Ooh, my heart. (faints)
Drew and Jonathan's Kabuki in episode 22.
The game of Options in Episode 33. Colin speaking with a Scottish accent in Mexico.
Before one playing of "Options" in episode 8, Jeff calls on Steve, a guy in the audience from Cleveland.
Jeff: What's your favorite thing about Cleveland? (guy speaks) Jeff: "Nothing." That's why you're here! Drew: How about me, ya son of a bitch?!
Ice Age, especially around halfway through where Jonathan's expression changes as he reads his second sentence.
And from the same scene:
Ryan: Helen say to me, "Purple monkeys in the tree!" (Beat) That's sex talk with Helen.
Colin and Ryan's game of Sentences, "I like boys!"
While Jeff's audience-produced line of "I forgot to man-scape— you might not want to look down there" was hilarious on its own, the shot of Chip and Brad that follows it makes it even better. Chip's reaction is understandable, but Brad's deadpan is the best part of that entire sequence.
Just look at poor Wendy's reaction when Brad belts "I know you put out!" the first time— Chip certainly tried to defend her, but the way Brad turned it around on him was absolute gold— and it sounds so good when you hear it in the song:
In the game of First Date from episode 12, Jeff says loudly to Jonathan, "I don't want to go to this party, let's just go make out somewhere." Jonathan turns and regards him for a moment before catching everyone by surprise by walking right up to Jeff, kissing him a bunch of times and then walking away with his head held high, all the dignity in the world.