In Crysis 2, there is just something funny about the prompt coming up in front of a Ceph Tick saying "Press to Squish". Not crush, stomp, or flatten. Squish.Everything's Squishier with Cephalopods indeed. The trope title has never been so apt.
In one of the final missions, you are tasked with "rescuing" Hargreave and killing Commander Lockhart. Lockhart's quotes become annoying after a while (as they're repeated until you reach him), but his hammy performance keeps it amusing:
In the same mission, if you shoot the porta potty at the start, someone inside will yell, "Hey, it's occupied!"
The Marines constantly referring to Alcatraz as "suit guy".
Legion reveals that Alcatraz is a snarky little bastard. The highlight has to be when he Lampshades DARPA's decision that, in their opinion, after spelling out that the Ceph were likely aquatic-based beings, the best way, to take them down, was to drown them.
In the opening of 3, Psycho says he's "always been a team player". Cue Prophet analyzing his memories, which describe him as "renegade", "out of control", and similar ideas. "Conclusion: Incorrect Analysis."
This troper found Prophet's tone of speech when Psycho use an abandoned fuel-carrying train to plow through blocked path early in the game amusing.
At one point in the third game, Psycho and Prophet are sneaking through CELL-occupied tunnels, with Prophet constantly being berated for making too much noise. Eventually, they come to a place where they must split up. Psycho starts climbing a ladder, only to knock off a rung and send it clattering to the floor:
Psycho: Do you think they heard that? * the sound of multiple safeties being switched off comes from the next room* Psycho: ... I don't think they heard that.
During the beginning of the mission to destroy the hydroelectric dam, you can eavesdrop on a squad of CELL soldiers as they prepare to hunt for Prophet and hear this gem:
CELL Commander: Listen up. Intel suggests - Ah, fuck that. We are 100% goddamn positive the tin man is in this quadrant. You know his MO - the dam will be his primary target. We are deep inside the Hades radar shadow. That means no guns on this one. It's down to you assholes. So stick to the plan, don't fuck around, and cover each other. Any questions?
CELL 6: What's the meaning of life, sergeant?
CELL Commander: Fuck you Gomez.
Prophet and Psycho's reactions to the Ceph Mastermind. It's basically what Psycho and O'Neill said regarding the Red Hunter in Crysis: Warhead, except it doesn't work as well this time around.
Prophet: You seen that before? What the hell is it?