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Film: Mans Best Friend

Man's Best Friend is a 1993 horror film written and directed by John Lafia (Child's Play 2).

Television reporter Lori Tanner has just broken into a research facility and inadvertently lets loose a big, genetically altered dog named Max created by a Mad Scientist, Dr. Jarret (Lance Henriksen). Though docile around Lori, the dog is in danger of going through a psychotic break without the drugs needed to keep him emotionally stable, and exhibits loads of abilities that make him a more efficient killer. This is very bad news for the denizens of Lori's neighborhood.

This film contains examples of:

Angry Guard Dog / Beware Of Vicious Dog: Max.
Asshole Victim: Nearly everyone who meets their end at the teeth of Max is an unscrupulous prick.
Black Comedy Rape: Max on the Collie owned by Heidi's neighbor.
Chameleon Camouflage: One of Max's many abilities.
Covers Always Lie: The home video cover has a Robot Dog, but Max is only a genetic monster, not a cyborg.
Good Is Dumb: Maybe it wasn't a good idea to let loose the potentially dangerous lab animal.
Good Scars, Evil Scars: Max takes a blowtorch to the face, resulting in a nasty-looking red mark.
LEGO Genetics
Sequel Hook: Max impregnated his collie neighbor before getting blown into the next world and she has a litter of puppies, one of whom looks an awful lot like Max.
Shovel Strike
Swallowed Whole: Max chases the mean neighborhood cat into a tree, climbs after it and eats it.
Urine Trouble: Max has acid pee.
Well-Intentioned Extremist: While Dr. Jarret's experiments are questionable, he only created the ultimate Angry Guard Dog because his wife and child were killed and kept him under control with special drugs... which were cut as the Designated Heroine took Max from the lab, turning him into a killer machine.