An SCU agent who was framed for the murder of two cops while investigating the crime scene of a high profile serial killer. He spends the vast majority of the game trying to clear his name and track down the real culprit. His only weapons are a tazor, his SCU gear, and whatever he can find in the ruined enviroments around him.
- The Alcoholic: He can't even shoot right in the second game with drinking alcohol, although he does eventually get better.
- Ambiguously Human: In the first game, he displays near-superhuman strength, like when he's able to cling to the platform on the back of a train car that's about to fall off, and it's later revealed that he has an unusual bone structure.
- Beard of Sorrow: Grows one in the second game, after being forced to leave behind the Bureau and start living on the streets.
- The Brute: The FBI was interested in Thomas because of his unusually high skeletal and muscle density.
- Clear My Name: The entire goal of Condemned: Criminal Origins.
- Deadpan Snarker: More so in the second game than the first. When investigating the museum, upon seeing the bloody metal implants, he asks Rosa if Mayor Rachel Mars had "some sort of fucked-up masochistic lifestyle".
- Fingore: His showdown with Serial Killer X ends with him losing one of his index fingers.
- Humanoid Abomination: Ethan is a being with vocal chords like those of the Oro, and can use his voice as a weapon without the need for activation by metal implants.
- Made of Iron: Which is actually explained in the game itself.
- Parental Abandonment: Both of his parents were killed when he was a young boy.
- Sir Swears-a-Lot: He frequently drops slurred ClusterFBombs in the first game when he's swinging weapons or finishing off enemies, although they become a lot more audible as of the second game, and are not just used in combat.
- Took a Level in Jerkass: In the first game he seems pretty calm and rational, if not friendly (at least before he finds out that Vanhorn is keeping his murderous nephew in the back trunk). One of the first things he does in the second game is tell a bum who tried to help him off the ground to "piss off" while flipping him the bird.
Another SCU agent who believes in Ethan's innocence and helps him by deciphering the various clues Ethan comes across. While she plays a fairly minor role for most of the game she shows up for the library level to assist him in person and give him a taser upgrade.
- Man Bites Man: Or rather, woman bites man. SKX captures her in the library, but she bites his hand and he runs off.
- Mission Control: Spends most of the game just talking to Ethan on his phone and giving him information. She does help him out in the library level though.
A mysterious figure who shows up to help Ethan at a few points during the game. As it turns out he is Serial Killer X's uncle and felt somewhat responsible for his actions, which is why he helps Ethan track him down.
- Big Damn Heroes: Saves Ethan from being killed by Serial Killer X, though he didn't make it in time to stop him from losing a finger...
- Papa Wolf: When Thomas is thinking of killing his nephew, Malcolm threatens to shoot him before he kills Serial Killer X. Even when it was revealed of their relation, he knocks out Thomas to protect him.
- Sudden Sequel Death Syndrome: Unfortunately.
- Too Dumb to Live: He apparently didn't learn anything from his nephew choking him unconscious when he previously tried to save him.
The game opens with Ethan investigating one of his latest murders when things take a turn for the worst. His calling card is murdering young women and placing the corpses on display with a male mannequin. Found dead in the department store level, a victim of his own methods.
- Hoist by His Own Petard: Serial Killer X, whose entire MO is this trope, kills him and then poses his body with a mannequin, just like he did with his own victims.
The Torturer/Carl Anderson
A serial killer who likes to drive his victims to suicide so that he doesn't deliver the final blow. Kills the teacher who ratted him out to the cops in the abandoned school, but falls prey to Serial Killer X not long afterwards.
- Cold-Blooded Torture: His specialty.
- Driven to Suicide: He prefers not to kill his victims directly, but rather, to torture them to the point where they'll just finish themselves off. Ends up killing himself once SKX mutilates him.
- Hoist by His Own Petard: Just like the Matchmaker, he meets his end in the same way he killed his own victims once Serial Killer X gets ahold of him.
- Stupid Evil: Going after your former teacher for ratting on you isn't such a smart idea, especially when you insist on using your usual methods — which the teacher described to the authorities as having been Carl's fantasies — to kill him.
Serial Killer X/(Leland Vanhorn)
The man who killed the two cops at the beginning of the game and framed Ethan for it. He spends most of the game killing other serial killers in the same why they killed their own victims. Ethan manages to confront him near the end of the game but is stopped before either of them manage to kill the other. His ultimate fate is left up to the player to decide.
- Ax-Crazy: He's violent and uncontrollable. His uncle learned this the hard way.
- Bald of Evil: He has a shaved head in the sequel.
- Big Bad: Of the first game.
- Driven to Suicide: If the player chooses to spare him, he shoots himself. Subverted in that he's revealed to be Not Quite Dead in the sequel.
- Facial Horror: In the second game, he's missing a huge chunk of his face from a bullet wound, and has an "X" carved into his forehead.
- For the Evulz: His pretenses of righteousness are just an excuse. He clearly loves the thrill of hunting down serial killers and killing them using their own methods.
- Genius Bruiser: He is quite intelligent, given his ability to stalk you for months leading up to the events of the game and hunt down several serial killers to kill them before you can capture them and is shown to be a strong fighter, as he is able to defeat several foes at the same time when you see him in the subways, and battles you face to face during the endgame, even if he spends most of the fight running away and trying to ambush you.
- Hoist by His Own Petard: His entire MO is based around this. He hunts down other serial killers and murders them, and uses their signature.
- Jerkass: Besides being a sanctimonious serial killer and Knight Templar, a lot of his lines consist of him insulting and belittling Ethan.
- Knife Nut: Wields a large hunting knife when he confronts Ethan towards the end of the first game, and uses this same knife to kill three SCU agents in his Villainous Rescue of Ethan in the second game.
- Knight Templar: Convinced he's on the path of righteousness, and will kill anyone who he sees as hindering him on that path. Apparently dropped in the sequel, instead he's motivated by figuring out how the Oro work so he can take on their power.
- Serial-Killer Killer: Goes after all the killers Ethan hadn't managed to catch and by the time the game begins has already managed to kill most of them.
- The Sociopath: He's a vicious, remorseless Serial Killer. While he has murdered other serial killers, he has also murdered many innocent people.
- Stalker Without a Crush: Has been following Ethan's progress in the F.B.I. and spying on him in his apartment.
- Ungrateful Bastard: Malcom rescues him from Ethan. How does he repay him? By choking him unconscious. Then, after sustaining a bullet wound, Malcom nurses him back to health, only to be killed afterwards.
- Villainous Rescue: In the second game, he stabs an SCU agent who was about to kill Ethan, and then tells him to run. The two of them hide in a room, and he dispatches a couple more agents before turning on Ethan and telling him to "think of [his rescue] as a future investment".
Oro Dark Primary
The final boss of the game who fights Ethan in a surreal landscape after stalking him throughout the rest of the game. Implied to have been involved in almost all of the events in the game in one way or another and appears many times in Ethan's mind before then. Is killed after Ethan removes several metal pieces from its body, crushes its neck, and drops it to the ground from the top of the platform he was standing on.
- Body Horror: And you have to kill it by ripping the metal parts from its body out one at a time!
- The Corrupter: Vanhorn blames it for Leland's murders and violent behavior.
- Humanoid Abomination: It's never made clear just what it is, but unlike most of the game's enemies, it cannot be considered human.
- Reality Warper: Can alter the scenery to something a lot more Mind Screw-y.
Director Ike Ferrel
The director of the Serial Crimes Unit of the FBI. He spends most of the first game trying to convince Ethan to give himself up, believing him to be responsible for the murder of the two police officers at the beginning. The second game reveals that he's a member of the Oro, who wants to try to persuade Ethan to join them.
- Ambiguously Human: Like many high-ranking Oro members, he can pass as a normal human, despite being far from it.
- Body Horror: Has a lot of metal implants in his body, which he needs to take medication for regularly.
- Da Chief: Unconvinced that Ethan is innocent of the murders of Dickenson and Becker, he does all he can to try and convince him to give himself up, eventually terminating his lab access.
- Reasonable Authority Figure: A villainous example. Unlike Dorland, who wants to kill Ethan because he sees him as a threat to the Oro, Ferrel wants to keep him safe because he sees him as a potential ally.
- The Voice: Ferrel is never shown in the first game. You only hear him over his phone conversations with Ethan.
- Your Head Asplode: Ethan eventually blows his head up with his voice.
A rather aggressive SCU agent in Bloodshot
who wears his contempt for Ethan on his sleeve. He's actually a high-ranking member of the Oro who sees Ethan as a threat to their organization, and thus, wants him dead.
Agent Pierce LeRue
A friendly SCU agent who helps Ethan out in Bloodshot.
- Badass Normal: Unlike any of the major antagonists, or Ethan himself, he's just a guy with a gun. That doesn't stop him from bulldozing a hole in Black Lake Lodge and holding off Dorland's men.
- Big Damn Heroes: Rescues Ethan from Black Lake Lodge when it looks like Dorland's men have him outgunned.
- Black Best Friend: Really, besides Rosa, he's the only person Ethan can really trust. Unlike Vanhorn or Ferrel, he has no agenda, and offers to get Ethan a drink at the end of the game, which the now-recovering Ethan declines.
- Nice Guy: Probably the nicest character in either game. He never loses patience with the hot-tempered, alcoholic Ethan, displays concern for his well-being, and even rescues him from Dorland's men at Black Lake Lodge.