A Real Life example - In 2010, the UK's Official PlayStation Magazine held a poll for the readers to vote for the best PlayStation game across all three home consoles since 1995 - Uncharted 2: Among Thieves was at the top of the list, with Metal Gear Solid and Final Fantasy VII at numbers two & three respectively. Think about that.
Another Real Life one - When one thinks of Uncharted, they most likely think "The best Indiana Jones game ever." This in mind, how does Sony advertise Uncharted 3? Harrison Goddamn Ford.
And another one for Elena towards the end of the game, where she stands her ground against the Big Bad who is not only about two heads taller than her, but also happens to be pointing his gun in Nate's face at the time. Nate has to actually talk her down.
The standoff itself is enough on its own, but then she charges Lazarević with an unflinching "BACK OFF!". She may be small, but she certainly packs a punch.
Rescuing Sully. It has to be played just to see how amazing it is. Even if he was never captured in the first place.
Nate's been drugged and captured. He's fought his way through a ship graveyard infested with pirates all on his own. He's washed up ashore, exhausted and injured. His first thought? Go rescue Sully. It's Elena who makes him lie down and rest. Made even more awesome by the fact Elena was ready to do the same thing if Nate hadn't shown up.
The entire plane level is pretty cool, but the most awesome part has to be as it's falling apart, and Nate gets sucked out...but survives by grabbing hold of a cargo crate and releasing the parachute, all while in mid-air! Seriously, only Nate could think fast enough in that situation to figure out how to survive.
From a narrative and artistic standpoint, the entire sequence of Nate getting lost and slowly dying in the Rub' al Khali desert.