In the last episode of the anime, after Tohru, exhausted and terrified, has nevertheless embraced Kyo after seeing his monstrous true form and he has become a cat again, she walks back to the house with cat-Kyo in her arms. Kazuma, in full martial-arts regalia, sees her as she approaches and does that graceful Japanese, one-hand-on-the-ground bow of respect to a superior. Wow.
In the early part of the story, Tohru briefly moves back in with her grandfather, who is now sharing his apartment with Tohru's paternal aunt and her kids. Her aunt's family makes it clear they see Tohru as something of a burden, until the aunt reveals she hired a private detective to do some checking on Tohru and knows she was staying with the Sohmas. The aunt's reasoning was that she remembered what Kyoko was like and figured "like mother, like daughter", and tells her not to do anything so "reckless" in the future if she wants to keep living with them. Her cousins then pretty much call her a whore, and Tohru stands there, silently taking it, until her grandpa slaps the male cousin. The anime makes this better by removing the Cloud Cuckoo Lander aspect of Tohru's grandfather.
Grandpa: Tohru, I apologize. Please don't think too harshly of them. They're just disagreeable folks by nature.
This is followed by Yuki and Kyo coming to the apartment to take Tohru back home. Tohru's cousin figures out they're "the guys the little tramp was shacking up with". Yuki's response just leaves the aunt's family speechless: his tone and delivery makes it clear they better shut their mouths if they know what's good for them.
Yuki: Don't you ever talk that way to Honda-san, you lowlife.
Toward the end of the story, the curse breaks, and one by one, the spirits of the Zodiac animals leave their human hosts. The first animal to arrive at the feast, the rat, is the last to leave, and as Yuki breaks down in tears, the spirit of the rat turns and runs toward a pair of welcoming hands. The final panel is God, surrounded by his animals looking back and saying goodbye.
Also, when Tohru finallyturns the tables on Akito Sohma by offering her genuine love and friendship. Keep in mind that Tohru, a simple schoolgirl without any self-defense training, is doing this towards a very unhinged Villainous Crossdresser who's in the middle of a terrifying Villainous Breakdownandhas a knife, which she just used to stab Kureno when he failed to get to her. Akito Sohma vs. Tohru Honda... Tohru Honda wins.. Wow... just WOW.
Just before this: Tohru and Kyo finally hug - and Kyo doesn't change.
Momiji, who is not a tough guy (to put it mildly) interposes himself between an angry Akito and Tohru despite knowing that Akito has on several occasions maimed those who defy her.
In chapter 20, Akito comes to introduce himself er, herself to Tohru, and threatens Yuki. For the first time in the series, Tohru acts otherthan kind and sweet and is, considering her normal behavior, terribly impolite, pushing Akito away when she sees how distressed Yuki became.
What this troper always thought was a subtly awesome thing was that Hiro's parents genuinely love him very much. We have seen the Sohma family suffer so much from their parents that it's so refreshing to see at least one example that Sohmas don't make terrible parents!
And what is Ritsu's mother Meshou, though? The woman's a super Fragile Flower but she does love Ritsu to death, and her short speech about how much she loves her son is made of win and sweet.
Not to put down Meshou's awesomeness, but what I always found amazing was that Hiro's parents did not get traumatized at all. She did not shun her son nor did she become overly protective. Satsuki is still very happy despite all the problems that inherently come from having a child possessed by the zodiacs (let alone Hiro's...unyielding personality). The crazy thing? She never hesitated. She didn't care that Hiro was a sheep at all. Even the other zodiacs couldn't help but call her an amazing mother.
When Yuki's mother begins planning out his entire life for him without any consideration for his own opinions during his parent teacher interview, by extension unearthing his own feelings regarding his self-worth, Ayame bursts in and cuts her off completely in his usual Large Ham fashion. He then proceeds to continue the interview, completely unfazed by his mother's fury and calls her out on her treatment of her own son, remarking that she was exactly how he used to be and unable to see how important family should be. Eventually, his effortless rebuffing of all her outbursts pisses her off into leaving, thus leaving Yuki free to choose his own future.
The Fruits Basket Radio Drama by JesuOtaku. Her "Summer Project" of 2011, it's a wonderfully voiced, expressive piece that Hope should be proud of forever.