- Creator-Chosen Casting: Werner Herzog cast Roland Topor as Renfield after seeing him in a French TV show. He had been greatly impressed with the crazy, utterly desperate laugh with which Topor had concluded his every statement on that show.
- Multiple Languages, Same Voice Actor: Isabelle Adjani and Roland Topor dubbed themselves in French.
- Never Work with Children or Animals: Procuring rats for the film proved difficult, though the production eventually procured a large quantity from a scientific research facility. When shipped to Holland for filming, a customs inspector reportedly fainted upon opening their crate and discovering its contents. In addition to the notorious dye job the rats had to endure, each had to undergo spaying or neutering to control their breeding. Animal rights activists have also alleged that the rats were underfed and actually began to eat one another during production.
- Promoted Fanboy: Werner Herzog considers Murnau's Nosferatu to be the greatest German film ever made.
- What Could Have Been: Sylvia Kristel was the first choice for the role of Lucy, but she rejected the offer because she did not want to work with Klaus Kinski, who was notorious for disrespecting women.
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