- B-Team Sequel: Amateur Surgeon 4 is the only game in the series that wasn't developed by MediaTonic, instead being made by Burke & Best.
- Keep Circulating the Tapes:
- The web versions of Amateur Surgeon 1, 2, and Christmas Edition are completely inaccessible due to the games running on Flash, which most browsers discontinued in 2020. The only way to play these games is via a Flash Emulator, such as Flashpoint.
- All of the mobile games have been removed from most app stores, and the servers to the mobile-exclusive games are currently defunct, making those games completely inaccessible without the use of hacks.
- Promoted Fanboy: A Let's Play YouTube channel that made videos for the whole series, Waffle Bros (then known as Spicywaffle), was given a cameo in the fourth game. In a side story surgery on Iron Wang, you have to extract a waffle with chili peppers on it, which is a reference to Waffle Bros' channel logo.
http://tvtropes.org/pmwiki/pmwiki.php/Trivia/AmateurSurgeon
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