The U-Foes, humans powered by a cosmic storm experiment, arrive to take over Hydra.
Meanwhile, a disgruntled politician named Truman Marsh announces that he is now in charge of overseeing all things Avengers-related after the team's encounter with the Inhumans.
- Adaptational Villainy: While the comic U-Foes are already straight-up villains anyway, they weren't agents of Hydra in their origin. There, they were simply a quartet who decided it'd be a good idea to expose themselves to cosmic radiation.
- Evil Power Vacuum: With Strucker missing, Hydra's got some leadership problems. Vector is only too happy to fill that void.
- Giver of Lame Names: Ironclad is the one who names the U-Foes, which Vector goes along with because he thinks it sounds good. Vapor doesn't think too much of it, or her brother's choice to call himself X-Ray.
- Obstructive Bureaucrat: Truman Marsh, who has somehow been unanimously granted unrestricted authority over the Avengers, and proceeds to be an utter jerk to them. Nothing they do is enough for him.
- Red Herring: The opening shows a stolen rocket craft taking off into a cosmic radiation storm. The name of the episode might be a clue this isn't a depiction of the origins of the Fantastic Four, helped by the U-Foes not identifying one another by name until after they've been mutated.
