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** Unlike their predecessors, the Spartan-[=IVs=] introduced in ''VideoGame/{{Halo 4}}'' are the first iteration of the program to successfully utilize adult volunteers, and are all equipped with an even more advanced version of MJOLNIR ([=GEN2=], to be precise) in order to compensate for their relatively inferior augmentations. Due to their comparatively normal backgrounds, the [=IVs=] are far more socially-adjusted than the [=IIs=] and [=IIIs=].

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** Unlike their predecessors, the Spartan-[=IVs=] introduced in ''VideoGame/{{Halo 4}}'' are the first iteration of the program to successfully utilize adult volunteers, and are all equipped with an even more advanced version of MJOLNIR ([=GEN2=], to be precise) in order to compensate for their relatively inferior (but more extensive and much better tolerated) augmentations. Due Pound for pound, they’re agreed to be less capable than the previous two generations, but they’re still well above human, mass-producible, and above all ''stable'': due to their comparatively normal backgrounds, the [=IVs=] are far more socially-adjusted than the [=IIs=] and [=IIIs=].

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** ''VideoGame/MetroidPrimeHunters'' introduces six new bounty hunters, one of whihc is Kanden, a lab experiment who was designed to be an unkillable super soldier. Unfortunatly for the program, Kanden escaped and destroyed the lab, killing everyon involved in his creation.

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** In ''VideoGame/MetroidPrime'' the space pirates created Project Helix, program to use Phazon to grow super soldiers that are much larger and stronger than normal. The end result was a series of Elite Pirates, and the Omega Pirate, an Elite who took to Phazon exceptionally well.
** ''VideoGame/MetroidPrimeHunters'' introduces six new bounty hunters, one of whihc which is Kanden, a lab experiment who was the end result of the Enomema Living Weapons Project, designed to be create an unkillable super soldier. Unfortunatly Unfortunately for the program, Kanden escaped and destroyed the lab, killing everyon everyone involved in his creation.
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** ''VideoGame/MetroidPrimeHunters'' introduces six new bounty hunters, one of whihc is Kanden, a lab experiment who was designed to be an unkillable super soldier. Unfortunatly for the program, Kanden escaped and destroyed the lab, killing everyon involved in his creation.
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** ''Literature/HaloShadowOfIntent'' reveals that the Covenant had their own super-soldiers in the Prelates, genetically modified Prophets capable of potentially matching even ''Spartans'' in a direct fight. However, they risk going into seizures if they remain in prolonged combat, making them useful only in short bursts.

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** ''Literature/HaloShadowOfIntent'' reveals that the Covenant had their own super-soldiers in the Prelates, genetically modified Prophets capable of potentially matching even ''Spartans'' in a direct fight. Particularly impressive considering the average Prophet is a NonActionGuy a ''[[ButtMonkey Grunt]]'' could tear apart in a physical contest without their technology. However, they risk going into seizures if they remain in prolonged combat, making them useful only in short bursts.
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** Let's face it, in her universe she's a combination of Franchise/{{Superman}}, ComicBook/IronMan, Franchise/{{Batman}}, Franchise/{{Wolverine}} and Franchise/GreenLantern. No wonder most people don't even think she's real anymore. The alliance soldiers think she's just a myth of propaganda, and the Space Pirates perception of her seems to be leaning towards an EldritchAbomination that exists solely to torment them for all eternity. It's [[AlwaysChaoticEvil Not like they don't deserve it, though...]]

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** Let's face it, in her universe she's a combination of Franchise/{{Superman}}, ComicBook/IronMan, Franchise/{{Batman}}, Franchise/{{Wolverine}} ComicBook/{{Wolverine}} and Franchise/GreenLantern. No wonder most people don't even think she's real anymore. The alliance soldiers think she's just a myth of propaganda, and the Space Pirates perception of her seems to be leaning towards an EldritchAbomination that exists solely to torment them for all eternity. It's [[AlwaysChaoticEvil Not like they don't deserve it, though...]]
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expanded the Fallout entry slightly, to reflect how high coursers' stats are.


** In ''VideoGame/Fallout4'', Institute Coursers are Franchise/{{Terminator}} expies designed to look exactly like humans but be superior to them in every way and tasked with hunting down wayward Synths. At one point in the game, you have to track down one of these murder-machines. You know the Gunners, those ruthless mercenary types who serve as {{Elite Mook|s}} versions of Raiders? The Courser you're looking for is inflicting a CurbStompBattle on an entire platoon of them when you find him, and no, it's ''not'' GameplayAndStorySegregation: he's a hell of a fight, even with a companion and power armour. [[spoiler:X6-88, who is a Courser you can recruit, has a SPECIAL stat total of ''98 points'', almost twice as much as your other companions' sums]].

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** In ''VideoGame/Fallout4'', Institute Coursers are Franchise/{{Terminator}} expies designed to look exactly like humans but be superior to them in every way and tasked with hunting down wayward Synths. At one point in the game, you have to track down one of these murder-machines. You know the Gunners, those ruthless mercenary types who serve as {{Elite Mook|s}} versions of Raiders? The Courser you're looking for is inflicting a CurbStompBattle on an entire platoon of them when you find him, and no, it's ''not'' GameplayAndStorySegregation: he's a hell of a fight, even with a companion and power armour. [[spoiler:X6-88, who is a Courser you can recruit, has a SPECIAL stat total of ''98 points'', almost twice as much as your other companions' sums]].sums, and more than even a fully leveled player character can have.]]
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* The protagonists and bosses of the shoot-em-up ''VideoGame/{{SUGURI}}'' and its prequel ''VideoGame/{{sora}}'' are all "altered humans" who have been modified to have superhuman strength, agility and durability, flight, and various other powers depending on the individual. The trope is emphasized more in ''sora'', which takes place during a ForeverWar in which the major characters are all fighting; the titular character in particular was designed to be the ultimate weapon of her country's military.

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* The protagonists and bosses of the shoot-em-up ''VideoGame/{{SUGURI}}'' and its prequel ''VideoGame/{{sora}}'' are all "altered humans" who have been modified to have superhuman strength, agility and durability, flight, and various other powers depending on the individual. The trope is emphasized more in ''sora'', which takes place during a ForeverWar in which the major characters are all fighting; the titular character heroine in particular was designed to be the ultimate weapon of her country's military.
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* The protagonists and bosses of the shoot-em-up ''VideoGame/{{SUGURI}}'' and its prequel ''VideoGame/{{sora}}'' are all "altered humans" who have been modified to have superhuman strength, agility and durability, flight, and various other powers depending on the individual. The trope is emphasized more in ''sora'', which takes place during a ForeverWar in which the major characters are all fighting; the titular character in particular was designed to be the "ultimate weapon" of her country's military.

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* The protagonists and bosses of the shoot-em-up ''VideoGame/{{SUGURI}}'' and its prequel ''VideoGame/{{sora}}'' are all "altered humans" who have been modified to have superhuman strength, agility and durability, flight, and various other powers depending on the individual. The trope is emphasized more in ''sora'', which takes place during a ForeverWar in which the major characters are all fighting; the titular character in particular was designed to be the "ultimate weapon" ultimate weapon of her country's military.

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* ''VideoGame/SwordOfTheStars'' has a couple of examples

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* The protagonists and bosses of the shoot-em-up ''VideoGame/{{SUGURI}}'' and its prequel ''VideoGame/{{sora}}'' are all "altered humans" who have been modified to have superhuman strength, agility and durability, flight, and various other powers depending on the individual. The trope is emphasized more in ''sora'', which takes place during a ForeverWar in which the major characters are all fighting; the titular character in particular was designed to be the "ultimate weapon" of her country's military.
* ''VideoGame/SwordOfTheStars'' has a couple of examplesexamples:
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* Mukuro Ikusaba in ''VisualNovel/DanganronpaTriggerHappyHavoc'' is a ChildSoldier with superhuman speed and reflexes that allowed her to spend three years on various battlefields without sustaining a single injury, earning her the title of "[[TheAce Ultimate]] Soldier".

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** By extension of a little logic, Sami's Infantry can become this during her [[LimitBreak Super CO Power]], which allows infantry of any health capture any property in a single turn. By graphical interpretation, a single, wounded infantry can on a heavily guarded opponent HQ in a single day...and win.

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** By extension of a little logic, Sami's Infantry can become this during her [[LimitBreak Super CO Power]], which allows infantry of any health capture any property in a single turn. By graphical interpretation, a single, wounded infantry can on a heavily guarded opponent HQ in a single day... and win.win.
* ''VideoGame/CallOfDutyBlackOpsIII'': With the advent of cybernetic technology, the most elite soldiers from every army are turned into "Cyber Soldiers", walking death machines with mechanical limbs connected through Direct Neural Interface systems. Even "normal" soldiers are equipped with exo-suits that augment their combat capabilities; these exo-suits are much smaller and less noticeable than the ones from ''VideoGame/CallOfDutyAdvancedWarfare'', and can be "hacked" with the right Cyber Core upgrade.

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*** They also had radically different results. Sephiroth was by far the strongest of the three. Eventually, he gained the ability to control the Jenova Cells perfectly....in exchange for losing all his humanity. Angeal received a weaker power boost, but inherited Jenova's ability to infuse other organisms with his cells to give them some of his power and vice versa. Genesis was a FlawedPrototype who shared Angeal's abilities but also suffered from degradation (as did his copies) -- and boy does this cause problems.

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*** They also had radically different results. Sephiroth was by far the strongest of the three. Eventually, he gained the ability to control the Jenova Cells perfectly....perfectly... in exchange for losing all his humanity. Angeal received a weaker power boost, but inherited Jenova's ability to infuse other organisms with his cells to give them some of his power and vice versa. Genesis was a FlawedPrototype who shared Angeal's abilities but also suffered from degradation (as did his copies) -- and boy boy, does this cause problems.



** Geralt can also brew potions that temporarily, or with rare ingredients permanently, further boost his augmented abilities. Unfortunately they're also toxic to varying degrees, and deadly to non-witchers

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** Geralt can also brew potions that temporarily, or with rare ingredients permanently, further boost his augmented abilities. Unfortunately Unfortunately, they're also toxic to varying degrees, and deadly to non-witchersnon-Witchers.
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** In ''Tiberium Wars'', GDI developed a much simpler super-soldier program for their commandos. There's no cybernetic enhancements or biological modification here, just [[TrainingFromHell extremely harsh and brutal training]] coupled with advanced armor and [[MoreDakka an automatic]] [[MagneticWeapons railgun.]]

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* ''VideoGame/MarvelVsCapcomClashOfTheSuperheroes'': The SecretCharacter known as Shadow Lady is [[Franchise/StreetFighter Chun-Li]] from an AlternateUniverse where she was [[ReforgedIntoAMinion forcibly turned into a]] [[UnwillingRoboticisation brainwashed cybernetic minion]] for Shadaloo. Before she was forcibly roboticized, Chun-Li routinely foiled Shadaloo's plans at every turn, and in retaliation, Shadaloo kidnapped, experimented and {{cyborg}}ized her for the sake of turning her into a pawn against Interpol. When the task was completed, they turned her into a living weapon, complete with a new name and transformed her into M. Bison's [[TheDragon top operative]]. Unlike Shadow--a roboticized Charlie Nash, who escaped shortly after being transformed--Shadaloo added a RestrainingBolt to Shadow Lady's programming and internal systems so the cyborg would [[CyberneticsEatYourSoul remain fully obedient and loyal to Bison]], and complete her missions by having her body be remotely controlled, essentially making her a [[DarkActionGirl Dark Action]] RobotGirl. As Shadow Lady, [[CyberneticsEatYourSoul Chun-Li's formerly cheerful personality was obliterated, and her body's physiology altered so it]] [[EmotionlessGirl experienced no emotion apart from being a ruthless but highly effective killing machine]] and assassin for Shadaloo - in essence, she is essentially a completely different person inhabiting her body and mind (being more machine than human), and serves as nothing but a weapon against her former allies and Interpol. It's also been implied that deep down, [[AndIMustScream the old Chun-Li is still there on some level]], and is at least partially aware of what she has done. Even if her allies ever managed to revive her, [[MyGodWhatHaveIDone Chun-Li would have to deal with the]] [[HeelRealization guilt of being a tool for Shadaloo]], not to mention the fact that [[RealityEnsues being a brainwashed robotic minion wouldn't go away overnight]] should she become a good person again. Aside from retaining a few moves from her non-cyborgified variant, she has built-in high tech weaponry, and all of this was augmented to her robotic body, like the T-X from the ''{{Franchise/Terminator}}'' series, thus making her more faster and stronger than Shadow, but at the cost of becoming a brainwashed minion for Shadaloo. She shoots [[HomingProjectile homing]]/[[MissileLockOn heat-seeking missiles]] from [[BackpackCannon her back]], thrusts forward with [[ThisIsADrill a drill]], encases herself in a [[ShockAndAwe electric barrier]] (that also [[DeflectorShields deflects attacks]] and stuns opponents), miniaturized Vernier thrusters in her feet that enable her to jump much higher (and allow her to kick more rapidly) and fires a large beam ([[ArmCannon Big Bang Laser]]) from [[HandBlast her palms]]. [[spoiler:In her ending however, she manages to [[HeroicWillpower overcome Shadaloo's brainwashing,]] [[HeelFaceTurn regain her original memories as Chun-Li]], and join forces with Shadow in taking down Shadaloo. Despite this, she retains her robotic parts even after the brainwashing broke.]]

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* ''Franchise/StarWarsLegends'': In the ''[[VideoGame/DarkForcesSaga Dark Forces]]'' games, the Dark Troopers, though in practice the first two generations were battle droids, the third generation could function as PoweredArmor, and the resulting combo could be called Super Soldiers.

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* ''Franchise/StarWarsLegends'': ''Franchise/StarWarsLegends'':
**
In the ''[[VideoGame/DarkForcesSaga Dark Forces]]'' games, the Dark Troopers, though in practice the first two generations were battle droids, the third generation could function as PoweredArmor, and the resulting combo could be called Super Soldiers.Soldiers.
** Delta Squad from ''VideoGame/StarWarsRepublicCommando'' are described as deluxe models that are superior to their more common bretheren. Indeed, the clone commandoes are equipped with heavy armor that features integrated DeflectorShields, a knuckle mounted vibroblade, and a SwissArmyGun. The player character, Boss, rightfully puts a standard trooper in his place when the trooper mouths off on his elite status on a mysteriously abandoned assault ship:
-->'''Clone:''' Ah, one of those deluxe models, come to save us with your "superior training?"
-->'''Boss:''' This "deluxe model" is the only thing standing between you and a bloody death, so you best be showing some respect, trooper.
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** Solid Snake himself. Big Boss was the single greatest soldier to have ever lived, but the Bikini Atoll atomic bomb experiment in 1954 rendered him sterile. The Les Enfantes Terrible project was an attempt to clone him, and Solid Snake and his brothers were the result. Snake is not explicitly superhuman [[BadassNormal but he is a]] GeniusBruiser with an IQ of 180, fluency in six languages, a polymath with an impressive knowledge of military science, genetics, biology, firearms and [[ZenSurvivor philosophy]]. He is [[WeDoTheImpossible "the Man Who Makes The Impossible, Possible"]]. In ''Metal Gear Solid'' alone, he faces a tank, a Hind gunship, a world-class Kurdish sniper, a renowned gunslinger, the world's most powerful psychic, a giant of a man who effortlessly wields a rotary cannon normally found on the nose of a jet, a {{Cyborg}} {{Ninja}}, and a 100ft tall prototype HumongousMecha with an arsenal of advanced weapons, and he beats '''all of them'''. [[spoiler:While also infected with a virus that is ''specially designed'' to target, weaken and kill him. ''He survives that too''.]]

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** Solid Snake himself. Big Boss was the single greatest soldier to have ever lived, but the Bikini Atoll atomic bomb experiment in 1954 rendered him sterile. The Les Enfantes Terrible project was an attempt to clone him, and Solid Snake and his brothers were the result. Snake is not explicitly superhuman [[BadassNormal but he is a]] GeniusBruiser with an IQ of 180, fluency in six languages, a polymath with an impressive knowledge of military science, genetics, biology, firearms and [[ZenSurvivor philosophy]]. He is [[WeDoTheImpossible "the Man Who Makes The Impossible, Possible"]]. In ''Metal Gear Solid'' alone, he faces a tank, a Hind gunship, a world-class Kurdish sniper, a renowned gunslinger, the world's most powerful psychic, a giant of a man who effortlessly wields a rotary cannon normally found on the nose of a jet, a {{Cyborg}} {{Ninja}}, and a 100ft tall prototype HumongousMecha with an arsenal of advanced weapons, and he beats '''all of them'''. [[spoiler:While also infected with a virus that is ''specially designed'' to target, weaken and kill him. ''He survives that too''.]]]] Now you know why Big Boss ''was''.

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* Solid Snake and several of the villains in the ''VideoGame/MetalGear'' series. All were the [[GeneticEngineeringIsTheNewNuke products of genetic engineering]], and many were just plain freaks of science.

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* Solid Snake and several Several of the villains in the ''VideoGame/MetalGear'' series. All were the [[GeneticEngineeringIsTheNewNuke products of genetic engineering]], and many were just plain freaks of science.science.
** Solid Snake himself. Big Boss was the single greatest soldier to have ever lived, but the Bikini Atoll atomic bomb experiment in 1954 rendered him sterile. The Les Enfantes Terrible project was an attempt to clone him, and Solid Snake and his brothers were the result. Snake is not explicitly superhuman [[BadassNormal but he is a]] GeniusBruiser with an IQ of 180, fluency in six languages, a polymath with an impressive knowledge of military science, genetics, biology, firearms and [[ZenSurvivor philosophy]]. He is [[WeDoTheImpossible "the Man Who Makes The Impossible, Possible"]]. In ''Metal Gear Solid'' alone, he faces a tank, a Hind gunship, a world-class Kurdish sniper, a renowned gunslinger, the world's most powerful psychic, a giant of a man who effortlessly wields a rotary cannon normally found on the nose of a jet, a {{Cyborg}} {{Ninja}}, and a 100ft tall prototype HumongousMecha with an arsenal of advanced weapons, and he beats '''all of them'''. [[spoiler:While also infected with a virus that is ''specially designed'' to target, weaken and kill him. ''He survives that too''.]]



** Not to mention the Genome soldiers [[spoiler: an attempt to create a army of Big Bosses quality soldiers]] from ''Metal Gear Solid''.

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** Not to mention the Genome soldiers [[spoiler: an [[spoiler:an attempt to create a army of Big Bosses quality Boss-quality soldiers]] from ''Metal Gear Solid''.

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* The Doom Slayer of ''VideoGame/Doom2016'' at first just appears to be a really strong and fast guy who can run circles around demons and punch them to LudicrousGibs but ''VideoGame/DoomEternal'' goes into more detail about his past and it's revealed [[spoiler:he's actually the ''original'' "Doomguy" from ''VideoGame/{{Doom}}'' and, after spending years and years in hell slaughtering demons as a BadassNormal, he came to live on Sentinel Prime with the other Night Sentinels and became one of their best soldiers. However at one point during a great war, a mysterious man named "Samur Maykr" put the Doomguy into a machine that gave him the power of the Maykrs, a race of hyper-advanced forerunner aliens. By doing this, he turned the otherwise unmodified human into a human-Maykr hybrid capable of the insane feats he's come to be known for]].



* The Doom Slayer of ''VideoGame/Doom2016'' at first just appears to be a really strong and fast guy who can run circles around demons and punch them to LudicrousGibs but ''VideoGame/DoomEternal'' goes into more detail about his past and it's revealed [[spoiler:he's actually the ''original'' "Doomguy" from ''VideoGame/{{Doom}}'' and, after spending years and years in hell slaughtering demons as a BadassNormal, he came to live on Sentinel Prime with the other Night Sentinels and became one of their best soldiers. However at one point during a great war, a mysterious man named "Samur Maykr" put the Doomguy into a machine that gave him the power of the Maykrs, a race of hyper-advanced forerunner aliens. By doing this, he turned the otherwise unmodified human into a human-Maykr hybrid capable of the insane feats he's come to be known for]].
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* The Doom Slayer of ''VideoGame/Doom2016'' at first just appears to be a really strong and fast guy who can run circles around demons and punch them to LudicrousGibs but ''VideoGame/DoomEternal'' goes into more detail about his past and it's revealed [[spoiler:he's actually the ''original'' "Doomguy" from ''VideoGame/{{Doom}}'' and, after spending years and years in hell slaughtering demons as a BadassNormal, he came to live on Sentinel Prime with the other Night Sentinels and became one of their best soldiers. However at one point during a great war, a mysterious man named "Samur Maykr" put the Doomguy into a machine that gave him the power of the Maykrs, a race of hyper-advanced forerunner aliens. By doing this, he turned the otherwise unmodified human into a human-Maykr hybrid capable of the insane feats he's come to be known for]].
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** Volkov was paired with a super ''attack dog'', Chitzkoi, who underwent the same augmentations that he did. In game mechanics, Chitzkoi behaves like a regular attack dog, but has almost ten times the health and can leap much further.

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** Volkov was paired with a super ''attack dog'', Chitzkoi, who underwent the same augmentations that he did. In game mechanics, Chitzkoi behaves like a regular attack dog, dog (instantly kills infantry, useless against anything else) but has almost ten times the health and can leap much further.
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** Volkov was paired with a super ''attack dog'', Chitzkoi, who underwent the same augmentations that he did. In game mechanics, Chitzkoi behaves like a regular attack dog, but has almost ten times the health and can leap much further.
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* Agent 47 of the ''VideoGame/{{Hitman}}'' series is a clone with DNA [[LegoGenetics donated]] by five high-profile criminals (A German mad scientist, a Chinese Triad boss, a Colombian drug lord, an Austrian terrorist-for-hire, and a Kazakstanian arms dealer.)

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* Agent 47 of the ''VideoGame/{{Hitman}}'' series is a clone with DNA [[LegoGenetics donated]] by five high-profile criminals (A German mad scientist, a Chinese Triad boss, a Colombian drug lord, an Austrian terrorist-for-hire, and a Kazakstanian arms dealer.)dealer). As a result, Agent 47 has slightly above human strength and stamina.
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** Geralt can also brew potions that temporarily, or with rare ingredients permanently, further boost his augmented abilities. Unfortunately they're also toxic to varying degrees, and deadly to non-witchers.

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** Geralt can also brew potions that temporarily, or with rare ingredients permanently, further boost his augmented abilities. Unfortunately they're also toxic to varying degrees, and deadly to non-witchers.
non-witchers
** There is also Leo from the first game, who is said to be an experiment by Vesimir to create a [[BadassNormal "pseudo-Witcher"]] with the physical conditioning and training Witchers go through, with help from the Grasses (herbal steroids), but not the now-lost mutation process. He can take on several human enemies on his own quite easily, but sadly unlike a "real" Witcher he cannot parry a crossbow bolt and the Professor exploits this to shoot him down dead.
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** Geralt can also brew potions that temporarily, or with rare ingredients permanently, further boost his augmented abilities. Unfortunately they're also toxic to varying degrees, and deadly to non-witchers.
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** Even regular {{mook}}s in the setting undergo extensive gene therapy to boost their strength, endurance and healing. Also standard is full-body heavy armor with full NBC protection and a sensor suite, plus other devices such as personal DeflectorShields that can take several hits from their own weapons and recharge within seconds, wrist-mounted matter fabricators, and grenades ''many'' times more powerful than any modern ones. Their weapons are mostly coilguns with effectively unlimited ammo that fire microcaliber projectiles at hypersonic speeds, that nonetheless generate recoil comparable to modern firearms (indicating that the rounds they fired are several times as energetic as their modern counterparts). These guns, from sniper rifles to [[HandCannon heavy pistols]] to light machine guns, be easily modded on the fly to fire [[GrenadeLauncer homing rockets and grenades]] or [[AbnormalAmmo various ammo types]] (armor-piercing, poison, incendiary, electric, etc.) with a flick from their aforementioned wrist-mounted matter fabricators. Many standard troops also have various other abilities, such as greatly enhanced shields, the ability to deploy autonomous drones, various heavy weapons spawned from the wrist fabricator, psychic powers, superhuman strength and durability, the ability to shoot [[ShockAndAwe lightning]] and [[PlayingWithFire multi-megajoule incendiary plasma rounds]] from their wrists, highly potent PowerPalms, invisibility, and so on. The only reason they're not thought of as super solders within the setting is that every other military threat out there is just as deadly.

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** Even regular {{mook}}s in the setting undergo extensive gene therapy to boost their strength, endurance and healing. Also standard is full-body heavy armor with full NBC protection and a sensor suite, plus other devices such as personal DeflectorShields that can take several hits from their own weapons and recharge within seconds, wrist-mounted matter fabricators, nano-fabricators, and grenades ''many'' times more powerful than any modern ones. Their weapons are mostly coilguns with effectively unlimited ammo that fire microcaliber projectiles at hypersonic speeds, that nonetheless which despite not expelling propellant (being EM weapons) and having small projectiles, generate recoil comparable to modern firearms (indicating that the rounds they fired are fire impact with several times as energetic as the kinetic energy of their modern counterparts). These guns, from sniper rifles to [[HandCannon heavy pistols]] to light machine guns, be easily modded on the fly to fire [[GrenadeLauncer [[GrenadeLauncher homing rockets and grenades]] or [[AbnormalAmmo various ammo types]] (armor-piercing, poison, incendiary, electric, etc.) with a flick from their aforementioned wrist-mounted matter fabricators.nano-fabricators. Many standard troops also have various other abilities, such as greatly enhanced shields, the ability to deploy autonomous drones, various heavy weapons spawned from the wrist fabricator, psychic powers, superhuman strength and durability, the ability to shoot [[ShockAndAwe lightning]] and [[PlayingWithFire multi-megajoule incendiary plasma rounds]] from their wrists, highly potent PowerPalms, invisibility, and so on. The only reason they're not thought of as super solders within the setting is that every other military threat out there is just as deadly.
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* The entire plot of the ''VideoGame/DeadOrAlive'' fighting game series is centered on Victor Donovan's attempts to create these by kidnapping {{Ninja}}s and cloning them.
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** While ''all'' Forerunner Warrior-Servants were this, the Prometheans were this even relative to other Warrior-Servants, as they had the Ecumene's most advanced combat armor and mutations. As seen in ''Halo 4'' and ''ComicBook/HaloEscalation'', [[spoiler:even a full squad of the best Spartan-[=IIs=] are no match for a single unarmed Promethean]].

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** While ''all'' Forerunner Warrior-Servants were this, the Prometheans were this even relative to other Warrior-Servants, as they had the Ecumene's most advanced combat armor and mutations. As seen in ''Halo 4'' and ''ComicBook/HaloEscalation'', [[spoiler:even a full squad of the best Spartan-[=IIs=] are no match for a single unarmed Promethean]].Promethean, although in fairness that one happened to be [[AuthorityEqualsAsskicking the Ur-Didact, the leader of and the best Promethean]]]].
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** Even regular Systems Alliance Marines undergo extensive gene therapy to boost their strength, endurance and healing. On top of that they all have personal kinetic barriers and weapons with effectively unlimited ammo that fire projectiles at relativistic speeds. The only reason they're not thought of as super solders within the setting is that every other military threat out there is just as deadly.

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** Even regular Systems Alliance Marines {{mook}}s in the setting undergo extensive gene therapy to boost their strength, endurance and healing. On top of that they all have Also standard is full-body heavy armor with full NBC protection and a sensor suite, plus other devices such as personal kinetic barriers and DeflectorShields that can take several hits from their own weapons and recharge within seconds, wrist-mounted matter fabricators, and grenades ''many'' times more powerful than any modern ones. Their weapons are mostly coilguns with effectively unlimited ammo that fire microcaliber projectiles at relativistic speeds.hypersonic speeds, that nonetheless generate recoil comparable to modern firearms (indicating that the rounds they fired are several times as energetic as their modern counterparts). These guns, from sniper rifles to [[HandCannon heavy pistols]] to light machine guns, be easily modded on the fly to fire [[GrenadeLauncer homing rockets and grenades]] or [[AbnormalAmmo various ammo types]] (armor-piercing, poison, incendiary, electric, etc.) with a flick from their aforementioned wrist-mounted matter fabricators. Many standard troops also have various other abilities, such as greatly enhanced shields, the ability to deploy autonomous drones, various heavy weapons spawned from the wrist fabricator, psychic powers, superhuman strength and durability, the ability to shoot [[ShockAndAwe lightning]] and [[PlayingWithFire multi-megajoule incendiary plasma rounds]] from their wrists, highly potent PowerPalms, invisibility, and so on. The only reason they're not thought of as super solders within the setting is that every other military threat out there is just as deadly.
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* ''VideoGame/{{Warframe}}'':
** The Tenno sit between this trope and [[PhysicalGod low-level gods]]; they're even called "warrior-gods" at least once. They have enhanced strength, durability, speed, and reaction times, combined with [[PowerOfTheVoid strange Void powers]] and [[ResurrectiveImmortality the ability to revive easily on death]]. [[spoiler:The Operators who pilot the warframes are just weak children with Void powers, but the warframes have the skills and physical enhancements to fight]].
** The Dax were the soldier caste of the ancient Orokin Empire. Not much is known about them, but they were extremely powerful, to the point that the Orokin felt the need to put in a RestrainingBolt: They cannot disobey anyone holding a Kuva Staff. [[spoiler:At least one of the warframes (Excalibur Umbra) was forcibly converted from a Dax soldier who discovered secrets that Ballas didn't want uncovered]].
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{{Super Soldier}}s in video games.
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* Any "Ultimate Weapon" revealed (and possibly fought) early in ''any'' game will eventually be fought more and more. In some cases, with more than one at a time. (See the Double El Gigante fight in ''VideoGame/ResidentEvil4'')
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* Caulder/Stolos' 'children' in ''[[VideoGame/NintendoWars Advance Wars: Days of Ruin]]''. Intended not for the front ranks, but for the command room, as their ability to assemble and react on tactical information in the field, as well as their encyclopedic knowledge of warfare, is far beyond that of a normal human. Tabitha/Larissa is also implied to have physical modifications as well.
** By extension of a little logic, Sami's Infantry can become this during her [[LimitBreak Super CO Power]], which allows infantry of any health capture any property in a single turn. By graphical interpretation, a single, wounded infantry can on a heavily guarded opponent HQ in a single day...and win.
* ''VideoGame/CityOfHeroes'', being a game about super powered individuals, is ''full'' of this trope. [[MegaCorp Crey]], [[ANaziByAnyOtherName The Council]], [[ThoseWackyNazis The 5th Column]], and [[EvilOverlord Arachnos]] all dabble in making Super Soldiers in the traditional sense. Other groups, like [[TheUndead The Vahzilok]], or [[{{Cyborg}} The Freakshow]] dabble in giving themselves super powers, but they lack the military organization of the big four.
* In ''VideoGame/CivilizationBeyondEarth'' this is what your infantry eventually turn into, one way or another. They start out as guys in NASA space suits with guns, but by end game, well it depends on which tech affinity you adhere to. With Harmony they are bio-armor wearing [[HalfHumanHybrid Half-Human, Half-Alien Hybrids]] that heal by breathing in ''poison gas''. With Purity bio-augmented seven foot giants in PoweredArmor that are about one step removed from 40K Space Marines. With Supremacy they are insectoid-looking more machine-than-man {{Cyborg}} shock troops. The ''Rising Tide'' DLC adds hybrid affinities. Supremacy-Harmony infantry look like biomechanical alien CyberCyclops. Harmony-Purity looks like an Ancient Egyptian holy warrior in gleaming gold-and-purple armor, genetically engineered to be godlike. Purity-Supremacy has a "perfect" human soldier operating an advanced armor with animal-level AI.
%%* In ''Colossatron: Massive World Threat'', Dropships will deploy these if not destroyed quickly.
* In ''VideoGame/CommandAndConquerRedAlert'' the Soviets created Volkov, the precursor to Nod's Divination and Cyborg program. Volkov is suppose to be an answer to Tanya, the Allies' mercenary commando, but far exceeds expectations since he can devastate ''tanks'' in addition to infantry and buildings. His metal endoskeleton also make him impervious to being crushed and can take a lot of punishment, far more than the human Tanya can. However, only one was ever made as the process was exceedingly expensive (and it's implied everyone else they tried this on did not survive the skeleton transplant).
* ''VideoGame/CommandAndConquerTiberianSeries'':
** The Brotherhood of Nod likes to experiment with Tiberium on humans (and weapons) attempting to create Super Soldiers. This is especially relevant for ''[[VideoGame/CommandAndConquerRenegade Renegade]]'', which features several mutant mooks in the later levels (which tend to be immune to Tiberium weapons, or are healed by it), as well as a boss. Which is somewhat of a parody of the original, the smallest character in the game. Havoc notes that "at least he's taller".
** GDI took a much more simple approach to the thing in ''[[VideoGame/CommandAndConquerTiberianSun Tiberian Sun]]'' -- they hired a Forgotten (humans mutated by Tiberium exposure, granting some degree of resistance to further damage from Tiberium exposure and accelerated healing when near Tiberium) veteran and gave him a [[MagneticWeapons railgun]].
** The Tiberium experiments Nod did during Renegade eventually lead to the creation and mass production of Cyborgs (who were already super soldiers by infantry standards) and among them certain ones were upgraded with Scrin Technology, creating Cyborg Commandos. These were powerful enough to level entire bases on their own and their plasma cannons can destroy the Mammoth [=MK2=] in just three hits.
* The Silencer and his brethren in ''VideoGame/{{Crusader}}'', whom you never actually fight in the games. However, properly equipped, a skilled player can scythe through hordes of lesser enemies, the implications being that a squad of Silencers would be both horrifying and overwhelming in a fight.
* ''Videogame/{{Crysis}}'''s Delta Force [[PoweredArmor nanosuits]] allow its users to [[InvisibilityCloak turn invisible]], survive a point-blank shotgun blast, to [[SuperSpeed run as fast as a Humvee]], and then flip it over by ''punching it'', all through the use of [[spoiler: reverse-engineered [[StarfishAlien Ceph]]]] nanotechnology. The sequel shows that the suit is capable of becoming even more - Alcatraz, a regular US Marine, is mortally wounded, then placed in a nanosuit, which [[ManInTheMachine keeps him alive]] by [[spoiler: [[BodyHorror growing into his wounds]] and eventually running most of his [[GrandTheftMe higher mental processes]]]].
* The Guardians in ''Videogame/{{Destiny}}'' were once dead humans and transhuman lifeforms who are resurrected by [[RobotBuddy Ghosts,]] sent by [[SufficientlyAdvancedAlien the Traveler]] to raise soldiers to protect and fight for it and those it is protected (in this case, the rest of humankind). Every Guardian is empowered by [[RealityWarper the Light]], granting them [[PracticalMagic phenomenal powers]], [[HealingFactor rapid healing]], and ResurrectiveImmortality, and every Guardian is [[OneManArmy able to mow down hordes of opponents.]] Interestingly, the Guardians' methods of fighting don't focus on conventional warfare, because they don't have the manpower to take and hold ground or fight in open battles against enemy armies and navies; instead they capitalize on their strengths, with the Guardians focusing on precision attacks on enemy logistics and support, infiltration and sabotage of enemy ships and weapons, lightning-fast assaults against high value targets, and other forms of aggressive guerilla warfare that leave much larger and more powerful and conventional enemy armies leaderless and unable to attack.
* ''VideoGame/DeusExHumanRevolution'': Depending on play style, Adam Jensen can be either a super soldier or a super spy, or you're really good, ''both''. [[spoiler: It's heavily implied in-game that he was bred to be more compatible with augmentation than the average human, and that he is the stock from which [[VideoGame/DeusEx the Dentons]] were cloned]].
** There are also the [[http://deusex.wikia.com/wiki/Tyrants tyrants]], augmented mercenaries and the only enemies you actually have to kill for them to stay down.
* ''VideoGame/{{DonPachi}}'' features the [[TitleDrop DonPachi]] Squadron, an elite air force unit. Clearing the first loop reveals that in order for prospective members to be able to take on massive enemy forces, they are ordered by their commander to slaughter the entirety of '''their own forces''', and that this training process goes on for at least ''seven years.''
* ''Franchise/DragonAge'':
** The golems of ''Videogame/DragonAgeOrigins'' straddle the line between Super Soldier and AttackAnimal with the reveal that [[spoiler:they are created by entombing dwarves in stone statues and infused with molten lyrium.]] The golems' might gave the Dwarves a fighting chance against the Darkspawn, and losing the means to create more of them turned the tides of war against the Dwarves. Most of the few active golems remaining are kept on a leash via control rods, though a few still retain free will.
** The Grey Wardens downplay this trope. Becoming one involves going through the Joining, a ritual that poses a significant risk of killing you. ''Surviving'' the ritual [[InformedAttribute apparently]] [[GameplayAndStorySegregation gives you]] enhanced strength and durability, along [[MySignificanceSenseIsTingling the ability to sense the darkspawn]], [[spoiler:but it means you'll have a hard time having kids and you'll be dead in less than thirty years]]. However, Wardens are vital to fighting a Blight, as they're immune to the [[TheHorde darkspawn]] taint [[spoiler:and are the only ones who can permanently kill an Archdemon and end the Blight]].
** Fenris of ''VideoGame/DragonAgeII'' is another example, of the "angry victim seeking revenge on his creator" variety. He was originally a normal elf, but the mage who owned him as a slave had [[GreenRocks lyrium]] etched into his skin all over his body, an agonizingly painful process that gave him the ability to become partially insubstantial (and possibly made him stronger and more agile as well). He uses this power to resist injury... and reach into people's chests to crush their hearts.
* ''VideoGame/{{Fallout}}'':
** The Super Mutants are the product of a pre-war super soldier research project meant to create strong, aggressive soldiers resistant to injury, radiation and environmental extremes. [[spoiler:They were later adopted by the Master as a new, superior version of humanity better suited to the nuclear wasteland of the post-apocalyptic future, meant to be able to easily overrun and replace regular humanity. They didn't come out quite as expected -- their transformation makes them sterile as mules, and thus not viable as a self-sustaining species.]]
*** Notably, the two big flaws [[spoiler: for the Master wouldn't have been an issue for the pre-War super soldier project: almost every human back then was, effectively, pristine Vault material, so no need to go hunting for subjects that turn into ''smart'' mutants rather than dumb ones, and the fertility issue is a perk rather than a flaw if you want supersoldiers rather than a race intended to replace baseline humanity]].
*** As seen in ''VideoGame/Fallout3'', Vault-Tec performed similar experiments on the residents of Vault 87 with a modified strain of the FEV, and the resulting Mutants turned out even dumber than their West Coast counterparts, as well as having the side effect of [[MiracleGroMonster increasing in size with age]]. Only [[GeniusBruiser Fawkes]] retained his human intelligence.
*** Even by the standards of Super Mutants, Frank Horrigan from ''Videogame/Fallout2'' is a beast. Clad in the finest Enclave PoweredArmor which doubles as life support, Frank Horrigan is one of the deadliest beings to ever walk the wastelands. That is, until he met TheChosenOne, of course.
** The [[NamesToRunAwayFromReallyFast rather aptly-named]] {{De|monicSpiders}}athclaws were created by the pre-Great War government using genetic engineering to replace human troops in battle, [[spoiler:and further refined by the Master using the same FEV virus which created the Super Mutants]]. The end result is a ten-foot tall reptilian monstrosity with twelve-inch long claws which are capable of shredding through all but the heaviest body armour, and a thick hide which is impervious to small-arms fire and explosives. [[spoiler:In ''3'', the Enclave tried to weaponize them for use as shock troops]]. Deathclaws are ShroudedInMyth and few people in-universe have even encountered them, but the ones that have invariably describe them as tanks with legs.
** In ''VideoGame/Fallout4'', Institute Coursers are Franchise/{{Terminator}} expies designed to look exactly like humans but be superior to them in every way and tasked with hunting down wayward Synths. At one point in the game, you have to track down one of these murder-machines. You know the Gunners, those ruthless mercenary types who serve as {{Elite Mook|s}} versions of Raiders? The Courser you're looking for is inflicting a CurbStompBattle on an entire platoon of them when you find him, and no, it's ''not'' GameplayAndStorySegregation: he's a hell of a fight, even with a companion and power armour. [[spoiler:X6-88, who is a Courser you can recruit, has a SPECIAL stat total of ''98 points'', almost twice as much as your other companions' sums]].
* TheEmpire in ''Videogame/FinalFantasyVI'' used [[PoweredByAForsakenChild drained magical power]] both to create [[FunctionalMagic magic-wielding super-soldiers]] (called Magitek Knights in the translation, but simply ''madoushi'' - mages - in the original) and actual {{Magitek}}. Celes is an example of when it goes right, but Kefka is what happens when it goes [[WithGreatPowerComesGreatInsanity horribly]], [[OmnicidalManiac horribly]] ''[[AGodAmI wrong]]''.
** It's even worse with Kefka than one initially thought, as [[PsychoPrototype he was the first of the Magitek Knights]].
* ''Videogame/FinalFantasyVII'' (and its associated Compilation works including ''VideoGame/CrisisCore'') include numerous Super Soldiers, many of which were created using Mako energy, Jenova cells, a combination of both, and/or other experiments, to produce superhuman fighters with greatly improved combat abilities, including (but certainty not limited to) enhanced physical strength and speed.
** [=SOLDIERs=], members of Shinra's elite military unit, are carefully selected humans [[BioAugmentation treated with Mako energy and Jenova cells]] to produce superhuman combatants.
** Sephiroth, Genesis, and Angeal, while generally called [=SOLDIERs=] First Class, are actually prototypes for competing Shinra research projects directed to infusing humans with Jenova's genes.
*** Sephiroth was created by directly infusing a developing fetus with Jenova cells (Project S, headed by Hojo).
*** Unlike Sephiroth, Angeal was indirectly exposed to Jenova cells because his mother Gillian was the one injected with Jenova cells before his birth, while Genesis was exposed to Jenova cells even more indirectly with his mother being treated with cells harvested from Gillian (Project G, headed by Hojo's rival Hollander).
*** They also had radically different results. Sephiroth was by far the strongest of the three. Eventually, he gained the ability to control the Jenova Cells perfectly....in exchange for losing all his humanity. Angeal received a weaker power boost, but inherited Jenova's ability to infuse other organisms with his cells to give them some of his power and vice versa. Genesis was a FlawedPrototype who shared Angeal's abilities but also suffered from degradation (as did his copies) -- and boy does this cause problems.
** Zack Fair, probably the strongest of the officially and 'conventionally' produced (i.e., non-prototype) [=SOLDIERs=].
** Cloud Strife, while never an actual member of [=SOLDIER=], has all the physical enhancements of a [=SOLDIER=], thanks to Hojo's sadistic experimentation after the Nibelheim Incident.
** Vincent Valentine, an ex-Turk who becomes a shapeshifter with superhuman physical abilities thanks to Hojo's and Lucrecia Crescent's experiments.
** From ''VideoGame/DirgeOfCerberus'', Weiss, Nero, Rosso, Azul, Shelke, and the other members of Deepground, who underwent [=SOLDIER=]-type treatments as well as special individualized experimentation to develop unique powers. It was said they used Genesis as the basis, since his cells gained the ability to use Mako similar to Jenova, but without the degradation, losing your sanity (Well, okay, he did briefly lose his sanity, but for different reasons), and having a desire to smash a Meteor into the Planet to eat it for breakfast.
* ''Videogame/FinalFantasyVIII's'' [=SeeDs=], who are superhumanly boosted, cast powerful magic, and able to summon deific beings to smite their enemies. These guys are apparently so badass that ''nine'' of them (in three-man teams) are expected to hold off an entire invading army, complete with artillery and killer walking robots. Twelve more ''candidates'' to become [=SeeDs=] are expected to assault and clear out an entire ''city'' of enemy soldiers.
** Their single greatest advantage is actually the Guardian Forces, which allow, among other things, the casting of magic (which is insinuated as artificial and weak when used by anyone other than a Sorceress), the collection of magic, and the use of magic to increase abilities from well above average to omni-powerful. No other group specializes in junctioning magic, which is why [=SeeDs=] are so devastating. This makes a small, specialized group more than a match for most smaller armies, as long as they have specific objectives. The GF forces are capable of granting characters permanent stat boosts. If you assume the normal stat growth is "average" human stats, then it is possible endgame for [=SeeDs=] to be 3-5 times stronger, faster, etc using GF forces.
* A slightly less traditional form of the Super Soldier would be the black mages from ''VideoGame/FinalFantasyIX''.
** Both [[spoiler: Zidane and Kuja]] would fit better as Super Soldiers in this game, but it was only because unlike the rest of the Genomes, they were given souls. Makes you think what would happen if the other Genomes had gotten their souls too...
* The yin to Cloud's yang, Lightning from ''VideoGame/FinalFantasyXIII''. She can fly (well, actually, manipulate gravity) while machine gunning hordes of Mooks, and most amazingly do it all while protecting her modesty. And all that is before she gets her l'Cie powers.
** Lightning was actually more of a Mook herself, roughly equivalent to a police sergeant, so it can be inferred that the stuff she had access to was probably standard issue.
** It is revealed through the story that millions of l'Cie were created and trained to fight the ancient War of Transgression in secret bunkers. ''Eight'' of them were sufficient enough to [[spoiler: bring down a ''planet'']], so only God knows what a full force was capable of.
* ''VideoGame/FirstEncounterAssaultRecon'' is chock-full of Super Soldiers, including the Point Man and Paxton Fettel (products of Project Origin), Becket (product of Projects Paragon and Harbinger), and a mini-army of cloned Replica soldiers.
* Both sides' grunts in ''VideoGame/{{Fracture}}'' fall into this category while their more elite and powerful units can almost no longer be called human.
* Some factions in the ''VideoGame/{{Geneforge}}'' series attempt this with the [[UpgradeArtifact canisters]], but given that side effects include [[AGodAmI egotism]], [[UnstoppableRage severe anger management problems]], and {{Hallucinations}}, several give up and rely on {{Mons}}.
* The Combine Elites in ''VideoGame/HalfLife2'':
** The regular soldiers too are transhuman specimens. They have simply received less augmentation, which is more in line with placing an untrained civilian on the level of your average soldier quickly rather than enhancing average soldiers to superhuman levels, like the Combine Elites. The only pure humans in the Combine military are the Civil Protection officers.
* ''Franchise/{{Halo}}'':
** Master Chief Petty Officer John-117 and the other Spartan-II cyborgs. The program initially consisted of 75 trainees, chosen by way of genetic markers indicating for exceptional athleticism and intelligence, who were abducted and conscripted into the special forces at age six, trained into perfect warriors until age 14, and then subjected to a series of augmentations that rendered them practically invincible -- ''before'' they got suited up with the MJOLNIR Powered Assault Armor, which further enhanced their abilities. Unfortunately, only thirty-something trainees survived the augmentation process unscathed; most of the rest died, and a handful were crippled...though some of the latter were later rehabilitated[[note]]Halsey also confides in her journal that there were more [=Spartan-IIs=] than she led the "main" class, of which John and most of the [=Spartan-IIs=] were part of, to believe[[/note]].
** There's also the Spartan-[=III=]s, vengeful kids orphaned by the Covenant who were sent on suicide missions almost right from the moment they hit prematurely-induced puberty. They mostly lacked the exceptional genetics, MJOLNIR armor, and experience of the [=II=]s, but mostly made up for it with less-lethal augmentations (with a roughly 100% survival rate), a poor man's version of [[InvisibilityCloak active camouflage]], and far greater numbers (300-330 per company). The newest company also received illegal drugs that further enhanced their aggression, strength, endurance, and tolerance to injury.
** A handful of Spartan-[=III=]s, namely those who were good enough to meet the standards of the original SPARTAN-[=II=] program and therefore too valuable to waste on the standard S-III suicide mission, were taken out of their companies, reassigned to more elite units, and given the same MJOLNIR armor as the S-[=II=]s. Other Spartan-[=IIIs=] were taken out of their companies and paired up into two-man assassination-and-sabotage teams known as Headhunters.
** The predecessor to both programs was the ORION Project, later known as the SPARTAN-I program. Unlike its successors, the project used adult volunteers; unfortunately, despite the effectiveness of the [=ORION=]s, their abilities still fell short of what was hoped for, and they tended to both physically and mentally deteriorate later in life. The only confirmed Spartan-I seen in the games is [[spoiler:Sergeant Johnson]].
** Unlike their predecessors, the Spartan-[=IVs=] introduced in ''VideoGame/{{Halo 4}}'' are the first iteration of the program to successfully utilize adult volunteers, and are all equipped with an even more advanced version of MJOLNIR ([=GEN2=], to be precise) in order to compensate for their relatively inferior augmentations. Due to their comparatively normal backgrounds, the [=IVs=] are far more socially-adjusted than the [=IIs=] and [=IIIs=].
** ''Literature/HaloShadowOfIntent'' reveals that the Covenant had their own super-soldiers in the Prelates, genetically modified Prophets capable of potentially matching even ''Spartans'' in a direct fight. However, they risk going into seizures if they remain in prolonged combat, making them useful only in short bursts.
** While ''all'' Forerunner Warrior-Servants were this, the Prometheans were this even relative to other Warrior-Servants, as they had the Ecumene's most advanced combat armor and mutations. As seen in ''Halo 4'' and ''ComicBook/HaloEscalation'', [[spoiler:even a full squad of the best Spartan-[=IIs=] are no match for a single unarmed Promethean]].
* Agent 47 of the ''VideoGame/{{Hitman}}'' series is a clone with DNA [[LegoGenetics donated]] by five high-profile criminals (A German mad scientist, a Chinese Triad boss, a Colombian drug lord, an Austrian terrorist-for-hire, and a Kazakstanian arms dealer.)
** In ''Absolution'', 47's new handler is secretly heading a research project dedicated to creating a similar cloned assassin. The 14-year-old Victoria [[ActionGirl kicks]] [[ChildSoldiers serious]] [[PhlebotinumGirl ass]] and becomes the LivingMacGuffin of the game when she's targeted by a South Dakotan arms mogul.
* ''VideoGame/JakIIRenegade'' sets Jak up as one of these, {{Wolverine}}-style; experimented on against his will, he later breaks free and swears revenge on the people who did it to him. The experiments involved injecting him with Dark Eco, which gives him the ability to transform into [[SuperpoweredEvilSide Dark Jak]]. Dark Jak has enhanced strength and claws instead of nails, and (if you buy the upgrades) can: create an shockwave of Dark Eco by punching the ground; produce countless Dark Eco bolts; completely ignore all attacks; and transform into a gigantic form that's even stronger (capable of destroying vehicles with one or two hits). ''VideoGame/Jak3Wastelander'' drops the last two powers but adds invisibility and the ability to throw Dark Eco blasts.
* Ogmo from ''VideoGame/{{Jumper}}'' series is one, or at least supposed to be one. Aside from [[InASingleBound improbable jumping skills]], he's also [[BottomlessBladder designed to survive without food]] or light. For ''[[ReallySevenHundredYearsOld long]]''.
-->'''[[BigBad The Boss]]:''' Ogmo is not the ultimate soldier! He's just the retarded monster!
* ''VideoGame/{{Marathon}}'' has the Battleroids, [[WeCanRebuildHim dead soldiers reanimated with cheap cybernetics]]. They were first used in a dispute between two small asteroid governments, in which battleroids from both sides got inside their opposing asteroids and killed pretty much everyone, after which their use was banned and they were [[SealedEvilInACan put in stasis for safekeeping]]. 10 "military Mjolnir Mark IV cyborgs" were smuggled on board the'' Marathon'', but only 9 were killed when the Tau Ceti colony was [[EarthShatteringKaboom blown up]]. It is all but confirmed that the player character is the 10th, which would explain his OneManArmy capabilities.
* ''VideoGame/MarvelVsCapcomClashOfTheSuperheroes'': The SecretCharacter known as Shadow Lady is [[Franchise/StreetFighter Chun-Li]] from an AlternateUniverse where she was [[ReforgedIntoAMinion forcibly turned into a]] [[UnwillingRoboticisation brainwashed cybernetic minion]] for Shadaloo. Before she was forcibly roboticized, Chun-Li routinely foiled Shadaloo's plans at every turn, and in retaliation, Shadaloo kidnapped, experimented and {{cyborg}}ized her for the sake of turning her into a pawn against Interpol. When the task was completed, they turned her into a living weapon, complete with a new name and transformed her into M. Bison's [[TheDragon top operative]]. Unlike Shadow--a roboticized Charlie Nash, who escaped shortly after being transformed--Shadaloo added a RestrainingBolt to Shadow Lady's programming and internal systems so the cyborg would [[CyberneticsEatYourSoul remain fully obedient and loyal to Bison]], and complete her missions by having her body be remotely controlled, essentially making her a [[DarkActionGirl Dark Action]] RobotGirl. As Shadow Lady, [[CyberneticsEatYourSoul Chun-Li's formerly cheerful personality was obliterated, and her body's physiology altered so it]] [[EmotionlessGirl experienced no emotion apart from being a ruthless but highly effective killing machine]] and assassin for Shadaloo - in essence, she is essentially a completely different person inhabiting her body and mind (being more machine than human), and serves as nothing but a weapon against her former allies and Interpol. It's also been implied that deep down, [[AndIMustScream the old Chun-Li is still there on some level]], and is at least partially aware of what she has done. Even if her allies ever managed to revive her, [[MyGodWhatHaveIDone Chun-Li would have to deal with the]] [[HeelRealization guilt of being a tool for Shadaloo]], not to mention the fact that [[RealityEnsues being a brainwashed robotic minion wouldn't go away overnight]] should she become a good person again. Aside from retaining a few moves from her non-cyborgified variant, she has built-in high tech weaponry, and all of this was augmented to her robotic body, like the T-X from the ''{{Franchise/Terminator}}'' series, thus making her more faster and stronger than Shadow, but at the cost of becoming a brainwashed minion for Shadaloo. She shoots [[HomingProjectile homing]]/[[MissileLockOn heat-seeking missiles]] from [[BackpackCannon her back]], thrusts forward with [[ThisIsADrill a drill]], encases herself in a [[ShockAndAwe electric barrier]] (that also [[DeflectorShields deflects attacks]] and stuns opponents), miniaturized Vernier thrusters in her feet that enable her to jump much higher (and allow her to kick more rapidly) and fires a large beam ([[ArmCannon Big Bang Laser]]) from [[HandBlast her palms]]. [[spoiler:In her ending however, she manages to [[HeroicWillpower overcome Shadaloo's brainwashing,]] [[HeelFaceTurn regain her original memories as Chun-Li]], and join forces with Shadow in taking down Shadaloo. Despite this, she retains her robotic parts even after the brainwashing broke.]]
* ''Videogame/MassEffect2'' has three. First, Commander Shepard, who was killed and then brought back from the dead, and upgraded by use of what Miranda refers to as bio-synthetic fusion. Second is Miranda, who was genetically engineered to be the perfect woman (which apparently consists of the standard super soldier package, plus good looks). Last, is Grunt, who is genetically engineered to be the perfect Krogan, or "Pure Krogan".
** Also, Jack, who was engineered to become a superhuman Biotic.
*** Also any of the kids in the original biotic training program, until Kaiden killed the turian instructor, and the project was scrapped.
** Even regular Systems Alliance Marines undergo extensive gene therapy to boost their strength, endurance and healing. On top of that they all have personal kinetic barriers and weapons with effectively unlimited ammo that fire projectiles at relativistic speeds. The only reason they're not thought of as super solders within the setting is that every other military threat out there is just as deadly.
** Alec Ryder and his offspring Pathfinder Ryder surpass them all due to them being intertwined with the Simulative Adaptive Matrix or SAM via cybernetic implants. SAM is an ArtificialIntelligence who sees and feels everything the Ryder’s see and feel, and can enhance their physiology in a multitude of ways via Profiles. Therefore, Ryder can be enhanced with ImprobableAimingSkills one minute, switch to being a tech savvy [[TheEngineer combat engineer]] the next minute, become an unkillable StoneWall the next, become an up close shock trooper the next, a stealthy ninja the next, a GravityMaster biotic the next and so on. Not to mention the AwesomenessByAnalysis ability that SAM also grants.
* Solid Snake and several of the villains in the ''VideoGame/MetalGear'' series. All were the [[GeneticEngineeringIsTheNewNuke products of genetic engineering]], and many were just plain freaks of science.
** Heck, Solid Snake's best friend was also a super soldier, as well, both during the events of ''[[VideoGame/MetalGearSolidPortableOps Portable Ops]]'' (where he was a sole-surviving test subject of a CIA project to create the Perfect Soldier), and ''VideoGame/MetalGearSolid'' (when he was made into a [[CyberNinja Cyborg Ninja]]).
** Not to mention the Genome soldiers [[spoiler: an attempt to create a army of Big Bosses quality soldiers]] from ''Metal Gear Solid''.
** And to a lesser extend almost every single active soldier in the word in ''VideoGame/MetalGearSolid4GunsOfThePatriots'', [[spoiler: thanks to the nanobots]].
** By the time of ''VideoGame/MetalGearRisingRevengeance'', cybernetic enhancements have become commonplace among soldiers employed by the world's PrivateMilitaryContractors, making your average soldier an {{Elite Mook|s}}. Player character Raiden happens to be a OneManArmy Cyborg Ninja capable of slicing up HumongousMecha with his sword, however, so he can handle them quite easily in actual gameplay.
** ''VideoGame/MetalGearSolidV'' has the Skulls [[spoiler:Parasite Unit]] led by [[spoiler: Skull Face, the BigBad and leader of XOF]]. They usually serve as a HopelessBossFight whenever Snake has the misfortune to run into them during a mission, with good reason. They're effectively immortal (Snake can't kill them, only incapacitate them), have superhuman speed and agility, and attack in droves. They were created by [[spoiler:implanting ordinary soldiers with an ancient parasite, destroying most of their brain functions and effectively making them superpowered zombies.]] They're also [[spoiler:TheVirus, capable of infecting any ordinary humans in the vicinity]]. You're ''expected'' to run away from them.
* Samus Aran in the ''Franchise/{{Metroid}}'' series. Sam's pretty much got the complete Super Soldier package, being adopted by the [[SufficientlyAdvancedAlien fantastically advanced]] yet [[AscendToAHigherPlaneOfExistence consciously going extinct]] Chozo, who [[LEGOGenetics infused her with Chozo DNA]] to gain fantastic speed, strength, agility and sensory capacity, trained her as the last Defender (read: legendary universe-saving warrior/judge figure) and equipped her with a modular suit of PoweredArmor that's the envy of the galaxy. On top of this, she's largely fueled by a [[RoaringRampageOfRevenge burning desire to get back at the Space Pirates who trashed both of her homeworlds and left her orphaned twice over]]. If there's a better warrior in the series' galaxy, we haven't seen him, her or it yet.
** Not only that, she later gets infused with Metroid DNA, and has also been exposed to the highly volatile substance Phazon repeatedly. Additionally, her aforementioned PoweredArmor can [[PowerCopying utilize virtually any weapon or technology it comes across]], can hack into even the most secure networks just by LOOKING at it, and can determine the weakness of almost anything, animal or mineral, by the same process.
*** For bonus points, the word "metroid" in the Chozo language means "ultimate warrior."
** Also, most planets tend to [[EarthShatteringKaboom explode]] [[MikeNelsonDestroyerOfWorlds by the time she's done with them]]
** Let's face it, in her universe she's a combination of Franchise/{{Superman}}, ComicBook/IronMan, Franchise/{{Batman}}, Franchise/{{Wolverine}} and Franchise/GreenLantern. No wonder most people don't even think she's real anymore. The alliance soldiers think she's just a myth of propaganda, and the Space Pirates perception of her seems to be leaning towards an EldritchAbomination that exists solely to torment them for all eternity. It's [[AlwaysChaoticEvil Not like they don't deserve it, though...]]
* In ''VideoGame/MonsterHunter'', it's stated by WordOfGod that the Hunters are all the descendants of these, who fought in an ancient war with the creators of the monsters. This explains their ability to wield weapons twice as large as themselves and [[MadeOfIron withstand tail whips and bites from gargantuan wyverns and dinosaurs]], previously written off as simple CharlesAtlasSuperpower.
%%* In ''VideoGame/NoOneLivesForever 2'', your character squares off against several super-soldiers.
* ''VideoGame/{{Overwatch}}'': Prior to the [[RobotWar Omnic Crisis]] the USA had a volunteer super soldier project whose subjects gained enhanced strength and reflexes. At least two of whom, Jack Morrison and Gabriel Reyes [[spoiler:aka Soldier 76 and Reaper/Soldier 24]], became founding members of Overwatch.
* ''VideoGame/{{Prototype}}'' has Blackwatch's Super Soldiers, soldiers infected with a modified form of the series' [[TheVirus virus]]. They're bigger, stronger, and faster than the regular {{Mooks}}, they can sniff the PlayerCharacter out almost instantly even when disguised, and can easily go toe-to-toe with the opposite side's EliteMooks, the hunters, and even TheProtagonist himself when in small groups.
* Speaking of ''Franchise/ResidentEvil'', the Tyrants are the best example of this trope in the whole series.
** [[spoiler:Albert Wesker]] might qualify, seeing how he was injected with a virus that enhanced his strength, speed, agility, durability, and healing to superhuman levels, and in ''VideoGame/ResidentEvil5'' it was known that the virus was given to [[spoiler:Wesker Children (Albert Wesker being one of these)]] to create a "evolved" race of human for serving Spencer, who [[AGodAmI envisioned himself to be the god of the new world]].
** It could be said that just about everything you encounter in the series is either this trope, or an attempt or side effect of creating this trope.
* ''VideoGame/ReturnToCastleWolfenstein'' has B.J. fighting Uber Soldats at some points in the game, such as the first time in a Lab, and three at the same time near the end. ''VideoGame/Wolfenstein3D: Spear of Destiny'' has the player fighting an Uber Soldat as a MidBoss as well.
** B.J himself may as well be considered one, [[OneManArmy given how fucking unstoppable he is]]. [[spoiler:In ''VideoGame/WolfensteinIITheNewColossus'', after he gets captured and decapitated by Frau Engel, he gets his head recovered by the Resistance and put on some kind of prototype Ubersoldat body, so he qualifies for real.]]
* ''VideoGame/SecondSight'' introduced two classes of super-soldier, created by the American Zener Project: the first is just an extremely well-trained marine that's been taught to create mental shields, which deflect bullets but not mind-blasts. The second- only encountered in the second-last level- are SuperpoweredMooks, loyal soldiers that have been given impressive psychic abilities via implanted stem cells taken from the original Zener Children [[spoiler: and John Vattic, the protagonist.]] By the end of the game, most of the two classes have either been killed in action, or [[spoiler: never existed at all.]]
* In ''VideoGame/SidMeiersAlphaCentauri'', with all the cloning, genetic engineering, cybernetics, and BrainUploading you can inflict on your civilians your mid to late game soldiers probably count. The [[TheSpartanWay Spartan]] [[TheSocialDarwinist Federation]] in particular.
* The Terran Ghost units in ''VideoGame/StarCraft''. As well as arguably every single Protoss unit.
** Well, the [[spoiler:Xel'Naga did choose them for uplift, based on their alleged purity of form.]] Also, the Zerg, the entire frickin' species. The Zerg [[LegoGenetics incorporate foreign genetic material]], and then make it into [[OrganicTechnology something more useful]] - like purpose-built killing machines, of which they have plenty. A single Zergling has a fair chance against a trained, armoured [[SpaceMarine Terran marine]] wielding a [[{{BFG}} gauss rifle]].
** Most Terran units are far more heavily augmented than they appear, which is more evident in SC2 than in the first game. The [[RedShirt Marine]] in the original SC2 trailer has multiple metallic sockets ''on his body'' and the Battlecruiser captain has a cybernetic eye.
** Assuming aliens count, Protoss are the very embodiment of this trope. Zealots, the most basic protoss soldier, are 9 ft tall cybernetically enhanced warriors with decades of training, plasma shields, laser beam wolverine claws, and apparently capable of walking as fast as a motor vehicle and charging much faster than that. Oh yeah, and they can absorb as much damage as a tank (and survive a direct tank blast to the face without even losing their shields - and a couple more when their shields are down!).
* ''Franchise/StarWarsLegends'': In the ''[[VideoGame/DarkForcesSaga Dark Forces]]'' games, the Dark Troopers, though in practice the first two generations were battle droids, the third generation could function as PoweredArmor, and the resulting combo could be called Super Soldiers.
* ''VideoGame/{{Stellaris}}'' has robots, [[CloneArmy clones]], [[PsychicPowers psychics]], and genetically engineered supersoldiers (unlocked with "Gene Seed Purification" tech). Available first as attachments to more conventional armies and later as whole armies.
* The Boosted Children and later the Machinery Children from ''VideoGame/SuperRobotWarsOriginalGeneration'' are basically this - though the Boosted Children were mainly just experiments that produced some good results, the Machinery Children were the "real deal". Similarly, the W-Numbers and Biodroids used by the Shadow Mirror and Inspectors; however, the Biodroids were mindless creations used to replace actual human losses, and the W-Numbers/-series were similarly purposed, but the W-series ended up with personalities.
** W00, The Prototype of the Shadow-Mirror's W-series in the ''VideoGame/SuperRobotWarsOriginalGeneration'' continuity turns out to be a Human [[spoiler:[[VideoGame/EndlessFrontier Haken Browning]], if you must know]]. The project was switched to androids like Lamia when they realized that it takes too long for Super Soldier babies to grow up.
* ''VideoGame/SwordOfTheStars'' has a couple of examples
** The Zuul were made by giving a race of flesh-eating marsupials a human-like intelligence, PsychicPowers (including the ability to MindRape knowledge out of their victims), a HiveMind, and a natural lust for exploration and conquest, the Zuul were created for exterminating any race that wouldn't be subjugated; cargoes of them were simply dumped onto any old planet whose inhabitants needed a good genocide. They became more wildly successful than their creators could ever have dreamed of, insofar they went on to [[ScaryDogmaticAliens voluntarily worship their creators as gods and view their genocidal purpose as a holy war against the unworthy]]. In the sequel, a [[DefectorFromDecadence Zuul splinter faction]] joins their former enemies the Liir in fighting the rest of the Zuul and their creators.
** Hiver members of the Warrior caste. While a worker is around the same size as a human, warrior cast hivers are far stronger and tougher, highly armored with plating, and one of the largest among any of the species in that universe. In game, this is reflected in Hiver ships being the toughest to successfully board.
* The titular battleforce from ''VideoGame/TemplarBattleforce'' is composed of these; each is a SpaceMarine with GeneticMemory that allows them to pilot their PoweredArmor.
* The bestial enemies in ''VideoGame/VivisectorBeastWithin'' are another rare {{Animorphism}} version of this trope, being created as warriors for the main antagonist's private army. Doubly intimidating, as they have both animal and cybernetic elements to augment their fighting prowess.
* ''VideoGame/TheWitcher'': Witchers fit the trope: alchemically and ritually augmented, made stronger, quicker, tougher than humans, and somewhat alienated from humanity because of it. They're meant for hunting monsters instead of fighting humans, but [[KnightInSourArmor Geralt]] [[HumansAreTheRealMonsters oftentimes doesn't really see much difference between the two]]. They're explicitly defined as genetically engineered (via alchemy) in a couple of places.

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