History Main / ManOfKryptonite

** In "Escaping Expulsion", [[Characters/TheOwlHouseAmityBlight Amity]]'s skill in Abomination magic allows her to easily overwhelm both Abomatons by manipulating their body mass.

* ComicBook/{{Aquaman}} villain The Thirst drains water from his surroundings and people, putting Aquaman at a serious disadvantage.

** ''Smallville'' Clark also has to deal with one of the main Superman invocations of this trope, Metallo. His condition is played for maximum BodyHorror as he's unwillingly transformed into this and still retains enough of his human form to express his horror. Making things worse, he had a FreudianExcuse already for hating Clark (he saved the life of someone who later killed Metallo's sister), and being transformed into a ManOfKryptonite cyborg broke his mind. Later he showed up using Red Kryptonite as a power source and had a mild HeelFaceTurn, as the mental effect of Green Kryptonite had played a part in his mental breakdown. The switch to Red K gave him enough sanity to realize what he had done and try to be heroic.

** Monkey D. Luffy is, famously, a RubberMan; consequently, he turned out to be a Man of Kryptonite for God [[SpellMyNameWithAnS Eneru/Enel]], a [[ShockAndAwe lightning-powered]] villain who was otherwise [[MadeOfAir undefeatable]].

** More commonly on the show, since KryptoniteIsEverywhere was a plot point (it arrived in a meteor shower alongside Clark, and proved to be an incredibly useful {{Unobtainium}}) it served as a MetaOrigin for many villains. Kryptonite radiation would grant people superpowers, so a lot of people unknowingly had kryptonite in their bodies; as Green Kryptonite also induced chemical imbalances in people's minds, many of these people became unstable [[SmugSuper Smug Supers]] who used their powers dangerously. In one case, the Season 10 episode "Harvest," Clark and Lois got trapped by a village of religious fanatics who all unknowingly had blue kryptonite in their bodies, so Clark was BroughtDownToNormal in their presence. Originally, Lana herself was unintentionally this at the beginning too, as she had a Kryptonite necklace that made Clark barely able to stand in her presence, which most thought was just because he had a crush on her until they realised it was serious.

* Comicbook/{{Aquaman}} villain The Thirst drains water from his surroundings and people, putting Aquaman at a serious disadvantage.

* People with ShockAndAwe powers, particularly Chain Lightning, to [[Comicbook/{{Shazam}} the Marvel Family]]. Although they are normally invulnerable, a big enough electric attack can simulate the magic lightning and force them to transform back into their normal forms.

* Black Alice is this to anybody with magical powers, even those as powerful as Comicbook/TheSpectre. She can temporarily [[PowerParasite drain the powers]] of any magical being into herself.

** In ''ComicBook/ElseworldsFinestSupergirlAndBatgirl'', ''Comicbook/TheJoker'' pumps kryptonite-based drugs into his bloodstream. So, his body gives off K-radiation which hurts and weakens ''Comicbook/{{Supergirl}}'' when she fights him.

** Logan is always at a severe disadvantage when up against a mutant who can manipulate metal like Magneto (The movies being explicit about it), because of his adamantium skeleton. In fact, Magneto singlehandedly kicked off Ol' Canucklehead's entire years-long Bone Claw/Feral arc after violently divorcing Logan from his adamantium in ''ComicBook/FatalAttractionsMarvelComics''. This was actually an added weakness- initially Magneto's powers only worked on magnetic metals- iron, nickel, and cobolt and their aloys and adamantium wasn't magnetic. By the 90s, however, Magneto's powers had grown to give him control over all metals regardless of whether or not they were actually magnetic.

* ''ComicBook/XMen:'' Colossus's ability to turn his skin into metal makes him another easy target for metal-manipulating foes like Magneto, who can fling him across the battlefield with minimal effort.

** Wolverine was also intially a Kryptonite Man for mechanical foes like the Sentinels, as he originally was indetectible by machines like motion sensors and cameras. Eventually, this power was removed and it hasn't been referenced in years.

* Pinocchio Vampire Slayer, where the main character's nose alone is the instrument of vampire destruction.

** This trope is the basis of original Venom Eddie Brock's new identity Anti-Venom, whose primary power is to destroy the Venom symbiote. However, Brock also has more general "purification" powers that remove any foreign or artificial enhancements from others. In essence, he's a Man of Kryptonite for ''everyone'' who doesn't have just an armor or an explicitly genetic basis to their abilities.

** The Trope Namer is a villain called the Kryptonite Man.

* '''ComicBook/XMen:''' Colossus's ability to turn his skin into metal makes him another easy target for metal-manipulating foes like Magneto, who can fling him across the battlefield with minimal effort.

* In the Franchise/MarvelUniverse, there are a couple of heroes being living weaknesses for a vampire. One are [[ComicBook/TheMightyThor Asgardians]] -- Dracula once found hard way their blood gives a temporary power boost but with devastating side-effects. The other is ComicBook/{{Runaways}} member Karolina Dean, whose blood is basically a liquid solar energy -- a vampire who once tried to bite her got obliterated from the inside.

* ''ComicBook/JusticeSocietyOfAmerica'': Per Degaton, a villain who can accelerate time, is one to Hourman, a hero with a literal HourOfPower.

* Per Degaton, a villain who can accelerate time, is one to ComicBook/{{Hourman}}, a hero with a literal HourOfPower.