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* Speaking of Lilith, the Incubus familiar itself qualifies. It is a familiar that almost completely copies your tear stats and effects, having one on a character without a blindfold will basically give you 20/20, except it can also [[UpToEleven copy]] ''[[UpToEleven that]]''.


* Plan C seems to be something of a last resort item, as it deals [[NoKillLikeOverkill 9,999,999 damage]] to every enemy in the room...but then kills Isaac three seconds later, meaning you'll lose if the exit doesn't spawn right where you're standing. However, if you have a character that can come back from the dead, like Lazarus, or have an item that can revive you, like Guppy, it's effectively a button to instantly deal with any boss you don't like. It'll even take out Delirium, but this only works for Lazarus.

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* Plan C seems to be something of a last resort item, as it deals [[NoKillLikeOverkill 9,999,999 damage]] to every enemy in the room...but then kills Isaac three seconds later, meaning you'll lose if the exit doesn't spawn right where you're standing. However, if you have a character that can come back from the dead, like Lazarus, or have an item that can revive you, like Guppy, Dead Cat, it's effectively a button to instantly deal with any boss you don't like. It'll even take out Delirium, but this only works for Lazarus.


* Libraries by themselves become an easy way to abuse the Book Worm transformation that needs you to pick up 3 books - the exact same amount (when it's not four) that is there in the Library. Even if you don't need the books, you won't go away with a free chance of double tear.

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* Libraries by themselves become an easy way to abuse the Book Worm transformation that needs you to pick up 3 three books - the exact same amount (when it's -- Libraries usually have three books in stock on average, if not four) that is there in the Library. four, though you can get unlucky and only find two. Even if you don't need the books, you won't go away books themselves, the transformation is a straight upgrade with a free chance no downside for the cost of double tear.a single key.



* Mr.ME! is a great asset in normal play, but utterly BREAKS Greed mode. You can use it to nab items in Shops or Devil Rooms without paying, and since Greed Mode lets you recharge items pretty quickly and has a shop that always restocks, you can gain a bunch of items for free.

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* Mr. ME! is a great asset in normal play, but utterly BREAKS Greed mode. You can use it to nab items in Shops or Devil Rooms without paying, and since Greed Mode lets you recharge items pretty quickly and has a shop that always restocks, you can gain a bunch of items for free.

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*Mr.ME! is a great asset in normal play, but utterly BREAKS Greed mode. You can use it to nab items in Shops or Devil Rooms without paying, and since Greed Mode lets you recharge items pretty quickly and has a shop that always restocks, you can gain a bunch of items for free.


*** Libraries, Boss Rush rooms, Angel Rooms and some of the new double-item Treature Rooms become a cornucopia, since the Void absorbs everything in the room without a need to choose an item to pick up.

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*** Libraries, Boss Rush rooms, Angel Rooms and some of the new double-item Treature Treasure Rooms become a cornucopia, since the Void absorbs everything in the room without a need to choose an item to pick up.one item.

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*** Libraries, Boss Rush rooms, Angel Rooms and some of the new double-item Treature Rooms become a cornucopia, since the Void absorbs everything in the room without a need to choose an item to pick up.


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* Libraries by themselves become an easy way to abuse the Book Worm transformation that needs you to pick up 3 books - the exact same amount (when it's not four) that is there in the Library. Even if you don't need the books, you won't go away with a free chance of double tear.


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** Then you add a Battery and do the same twice per room. And a Habit to retaliate with more when you're being hit by an enemy. ??? becomes literally unkillable.


* Speaking of Polyphemus, it synergises insanely with Brimstone. Polybrim, as it is sometimes called, deals insane amounts of damage (that can be more than doubled via the Brimsnap glitch[[labelnote:explanation]]Named after its discoverer, ''The Binding of Isaac'' [[YouTube YouTuber]] streamer [[https://www.youtube.com/channel/UCyHqXCNrWYWq2DksYJzwciQ Bisnap]], this glitch allowed you to fire off multiple invisible fully-charged Brimstone lasers by tapping a direction key multiple times after releasing the initial charge, without needing to charge again. This glitch was fixed in ''Rebirth''.[[/labelnote]]) and its only draw, the long charging time, can be bypassed, at least for one shot, by charging it up before entering a room with enemies. With this combo, you can one-shot all enemies ''and most bosses'' within seconds.

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* Speaking of Polyphemus, it synergises insanely with Brimstone. Polybrim, as it is sometimes called, deals insane amounts of damage (that can be more than doubled via the Brimsnap glitch[[labelnote:explanation]]Named after its discoverer, ''The Binding of Isaac'' [[YouTube [[Website/YouTube YouTuber]] streamer [[https://www.youtube.com/channel/UCyHqXCNrWYWq2DksYJzwciQ Bisnap]], this glitch allowed you to fire off multiple invisible fully-charged Brimstone lasers by tapping a direction key multiple times after releasing the initial charge, without needing to charge again. This glitch was fixed in ''Rebirth''.[[/labelnote]]) and its only draw, the long charging time, can be bypassed, at least for one shot, by charging it up before entering a room with enemies. With this combo, you can one-shot all enemies ''and most bosses'' within seconds.

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* Epic Fetus + the Conjoined transformation + 20:20 + Strange Attractor = a barrage of six obscenely powerful missiles at a time that draws enemies towards ground zero. Any regular room and almost any boss that doesn't have damage reduction will be cleared out in seconds. Unlikely to happen without a ton of rerolls, but worth it.

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* Death's Touch + Godhead + Proptosis + several damage ups = giant scythes with auras as large as the screen, both of which will kill regular enemies the instant they expose their hitbox and most bosses just a hair later. Even bosses with damage reduction won't last long.


* On their own, Glitter Bombs are useful but not ''too'' broken: each time one of your bombs explodes, it has a chance to drop a random pickup or trinket. But combine it with a golden bomb or either Fetus item, and congratulations--you now have an infinite pickup generator. With enough time, Luck, and patience, you can generate infinite health, infinite keys, infinite money (invaluable for Greed Mode!), infinite trinkets, and the list goes on. Combine it with items that cause your bombs to split, such as The Parasite + Dr. Fetus/Epic Fetus or Scatter Bombs, and it's possible to fill the entire room with goodies.

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* On their own, Glitter Bombs are useful but not ''too'' broken: each time one of your bombs explodes, it has a chance to drop a random pickup or trinket. But combine it with a golden bomb or either Fetus item, and congratulations--you now have an infinite pickup generator. With enough time, Luck, and patience, you can generate infinite health, infinite keys, infinite money (invaluable for Greed Mode!), infinite trinkets, and the list goes on. Combine it with items that cause your bombs to split, such as The Parasite + Dr. Fetus/Epic Fetus or Scatter Bombs, and it's possible to fill the entire room with goodies.

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* On their own, Glitter Bombs are useful but not ''too'' broken: each time one of your bombs explodes, it has a chance to drop a random pickup or trinket. But combine it with a golden bomb or either Fetus item, and congratulations--you now have an infinite pickup generator. With enough time, Luck, and patience, you can generate infinite health, infinite keys, infinite money (invaluable for Greed Mode!), infinite trinkets, and the list goes on. Combine it with items that cause your bombs to split, such as The Parasite + Dr. Fetus/Epic Fetus or Scatter Bombs, and it's possible to fill the entire room with goodies.


** Guppy also has gets a variant in the much easier-to-find Lord of the Flies. By finding three fly items (of which there are 12, 9 of which are Treasure Room items), you automatically become the Lord of the Flies, a flying bug man who converts almost all hostile flies into fly familiars.

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** Guppy also has gets a variant in the much easier-to-find Lord of the Flies. Beelzebub. By finding three fly items (of which there are 12, 9 18 post-DLC, 15 of which are Treasure Room items), you automatically become the Lord of the Flies, Beelzebub, a flying bug man who converts almost all hostile flies into fly familiars.


* Whore of Babylon [[DifficultButAwesome (the item that puts you in a One Winged Angel state which maxes out your attack so long as, regular heart-wise, you're only a single hit away from death)]] is this when used by [[spoiler:Blue Baby or The Lost]]. As they have no regular hearts (and can never get any), the effect is permanent.

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* Whore of Babylon [[DifficultButAwesome (the item that puts you in grants a One Winged Angel state which maxes out CriticalStatusBuff if your attack so long as, regular heart-wise, you're only a single hit away from death)]] character is this when reduced to one-half red heart or less (one full heart for Eve). This is normally situational, but if used by [[spoiler:Blue Blue Baby or The Lost]]. As they have no regular hearts (and can never get any), Lost, the effect is permanent.permanent because neither character is capable of gaining red hearts.


* Whore of Babylon [[DifficultButAwesome (the item that puts you in a One Winged Angel state which maxes out your attack so long as, regular heart-wise, you're only a single hit away from death)]] is this when used by [[spoiler:Blue Baby]]. As he has no regular hearts (and can never get any), the effect is permanent.

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* Whore of Babylon [[DifficultButAwesome (the item that puts you in a One Winged Angel state which maxes out your attack so long as, regular heart-wise, you're only a single hit away from death)]] is this when used by [[spoiler:Blue Baby]]. Baby or The Lost]]. As he has they have no regular hearts (and can never get any), the effect is permanent.


* Anti-Gravity. On the surface, it sets tears that stay put until you release the attack button, effectively making a [[DelayedCausality Delayed Attack.]] The Gamebreaking comes when mixed with either Monstro's Lung (Delayed Charged Attacks), or Brimstone. What makes [[CrazyAwesome Gravity Brimstone so overpowered]] is how it is fired: timed Brimstone Orbs that fires in the targeted direction. [[DifficultButAwesome While it is difficult to aim, it allows you to re-position yourself and fire another. Using either Spider Eyes or Inner Eye allows not only more Brimstone shots upon firing, but a larger Orb Radius to the point you can damage enemies with the orb itself.]]

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* Anti-Gravity. On the surface, it sets tears that stay put until you release the attack button, effectively making a [[DelayedCausality Delayed Attack.]] The Gamebreaking comes when mixed with either Monstro's Lung (Delayed Charged Attacks), or Brimstone. What makes [[CrazyAwesome Gravity Brimstone so overpowered]] is how it is fired: timed Brimstone Orbs that fires in the targeted direction. [[DifficultButAwesome While it is difficult to aim, it allows you to re-position yourself and fire another. Using either Mutant Spider Eyes or Inner Eye allows not only more Brimstone shots upon firing, but a larger Orb Radius to the point you can damage enemies with the orb itself.]]

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