History ArchEnemy / WesternAnimation

** Ladybug/Marinette also has [[Characters/MiraculousLadybugLilaRossi Lila Rossi]], who despises both of her identities despite not knowing they are the same person. Both of them have crushes on Adrien, which led to Lila developing a vendetta against Ladybug for exposing her lies to him, and when Marinette made it clear she wouldn't take any of Lila's verbal bait, she sought to turn all of her friends against her, at one point even getting Marinette expelled.

* In ''WesternAnimation/BewareTheBatman'', [[AscendedExtra Anarky]] of all people takes up the role, thanks to the Joker not being present in this version.

* In the Franchise/DCAnimatedUniverse, [[Characters/DCAULexLuthor Lex Luthor]] is still [[Characters/DCAUSuperman Superman]]'s primary enemy, but {{ComicBook/Darkseid}} and [[OmnicidalManiac Brainiac]] [[EvilerThanThou surpass]] him whenever they show up.
** And yet Luthor has survived direct dealings with both of them while even as both suffered grievous defeat. He was [[spoiler:fused with Brainiac]] and [[spoiler:personally put away Darkseid with the Anti-Life Equation who, it should be added, was even fused with Brainiac at the time]].
** Of all three though, Darkseid is easily Superman's most hated enemy. To put it in perspective, he is the only villain in the Franchise/DCAnimatedUniverse that Superman has no problem with killing, and actually ''WANTS'' to kill. Which is perfectly understandable as he's also the enemy who did by far the most damage to Superman, having murdered his friend Dan Turpin, brainwashed him into turning against Earth, causing him to become a pariah and lose Earth's trust for a while and getting Supergirl to be injured and nearly killed in the process.
*** The only one who was able to actually BREAK Superman was indeed Lex Luthor. That WAS the Justice Lord version, but he was still really, really close to it in the main DCAU also.
** Brainiac seems to consider Superman's father Jor-El to be his archfoe even though Jor-El is long dead. Brainiac never forgot that Jor-El opposed him to the very end and nearly destroyed him. For someone who supposedly lacks emotions, Brainiac took great pleasure in making "the son of Jor-El" kneel before him when he went back in time to kill teenage Clark. When Brainiac and Superman encounter each other on Apokolips, Brainiac claims that Superman has no hope of stopping him since his father couldn't.
*** It can be said that Luthor is this to Superman, Brainiac is this to "Kal-El", and Darkseid is this to "Clark Kent" (as he takes the threat of Darkseid more personally compared to the other two).
** [[Characters/DCAUJoker The Joker]] and [[Characters/DCAUBatman Batman]] in ''WesternAnimation/BatmanTheAnimatedSeries'' , its sequels, and ''Justice League''. Unlike the contemporary comics, where their battle is more or less [[ComicBookTime destined to go on forever]] (or at least until the next ContinuityReboot), the Franchise/DCAnimatedUniverse actually gets to show their rivalry from its early beginnings all the way to the inevitable, brutal final battle. The notion of an archenemy is also deconstructed; whereas Joker early on seems to hold Batman in high regard as a genuine WorthyOpponent, by the time of their final battle he openly admits to have grown utterly tired of their "game". Bruce himself also has no delusions about what kind of person Joker really was, and tells his successor as much decades after Joker's death.
--->'''Terry''': It's funny. I know about all your other major enemies, but, you never mention him. He was the biggest, wasn't he?
--->'''Bruce''': It wasn't a popularity contest. He was a psychopath. A monster.
** Joe Chill can also be seen as this to "Bruce Wayne" since he was the one responsible for killing his parents.
** Blight to [[Characters/DCAUTerryMcGinnis Terry McGinnis]] in ''WesternAnimation/BatmanBeyond''. Blight is the supervillain alter ego of [[BigBad Derek Powers]], a CorruptCorporateExecutive who took over Wayne Enterprises and had Terry's father murdered, therefore motivating him to take up Bruce Wayne's mantle and [[CreateYourOwnHero become Powers' greatest enemy]].

* For some reason or another, in ''WesternAnimation/SpiderManAndHisAmazingFriends'' from the 80s, his arch enemy was Doctor Doom. While the two have had s few historic encounters with one another in the comics, Doom is otherwise always depicted as an enemy of the ComicBook/FantasticFour above all else.
* In ''WesternAnimation/SpiderManTheAnimatedSeries'' all of the three traditional Spider-Man arch-enemies mentioned in the comic books section above are present, but the Green Goblin and Venom are both far less prominent, and Dr Octopus is downgraded to a B-list villain. Instead, the Kingpin serves as Spidey's main enemy.

* Ebon to Static in ''WesternAnimation/StaticShock''. Not only are his CastingAShadow powers directly opposite to Statics bright ShockAndAwe abilities, their worldviews are directly opposed too: Virgil's father run's the youth center, and his family active tries to help the community, especially kids; Ebon was a gangbanger who tries to "collect" metahumans into his super powered street gang.
** Francis (Hotstreak) is one to Static as well, or more accurately, one to "Virgil Hawkins". Their feud can be seen as personal due to Hotstreak bullying Virgil prior to them obtaining their powers. Their LightningFireJuxtaposition also makes them this way.

* Each of the ''WesternAnimation/TeenTitans2003'' had one:
** Slade to Robin. While Slade was largely the enemy of the Teen Titans as a whole (like in the comics), Robin became very obsessed with defeating Slade, and he in turn tormented him at every turn to force Robin to become his apprentice.
** Brother Blood to Cyborg. Blood was the head teacher of HIVE Academy, where the HIVE FIVE were from, but when Cyborg infiltrated the academy, Blood learned of Cyborg's cybernetics resisting his mind control powers., which inspired him to add his own cybernetics as a way to overcome this.
** Blackfire to Starfire. Blackfire being Starfire's [[CainAndAbel evil sister]] made their few interactions in the series very personal.
** Trigon to Raven. Trigon being Raven's ArchnemesisDad and one of the most powerful evils ever, he often sought to sway Raven, even as she refused to join him.
** Terra to Beast Boy. They formerly dated, until Terra became Slade's new apprentice, and it made things [[PsychoExGirlfriend complicated between them]]. They later made amends when Terra turned on Slade and redeemed herself at the cost of [[TakenForGranite turning to stone]].
** The Brotherhood of Evil became the greatest evil faced by everyone in the entire series, but on a personal level the Brotherhood (and specifically, the Brain) is Beast Boy's Arch Enemy. He was a member of the team that opposed them before he joined the Titans, and his past with them is what draws the other Titans into the conflict. Interestingly, this is a rare case of the hero taking it more seriously than the villain -- the Brain considers Mento, the Doom Patrol's leader, to be his Arch Enemy, and regards Beast Boy as little more than an irritant. Yet, thanks to Beast Boy (and by extension, the Titans), the Brain considers ALL {{kid hero}}es his archenemies.
* ''WesternAnimation/TeenTitansGo'': The H.I.V.E. Five are this to the Titans, being their most frequent appearing foes.

** [[Characters/TheSimpsonsHomerSimpson Homer Simpson's]] archenemies are [[Characters/TheSimpsonsCharlesMontgomeryBurns Mr. Burns]], Ned Flanders, Frank Grimes, and Patty and Selma.

** [[Characters/TheAmazingWorldOfGumballGumballWatterson Gumball Watterson]], and to a lesser extent, Darwin, have Rob. In fact, he became Gumball's Archenemy because he had no other role to fulfill as the Universe deemed him a mistake. He [[CreateYourOwnVillain blames Gumball]] for this, [[NeverMyFault even though he had nothing to do with Rob's predicament]].

** [[Characters/HowToTrainYourDragonFilmsHiccupHorrendousHaddockIII Hiccup Horrendous Haddock III]] had Dagur the Deranged, who sought vengeance on him after learning he deceived Dagur. Dagur eventually loses the position of Hiccup's archenemy to Viggo Grimborn, one of the few people capable of outsmarting Hiccup.

* [[CreepyChild The Delightful Children]] and Kids Next Door but especially Numbuh 1 in ''WesternAnimation/CodenameKidsNextDoor''.
** Numbuh 1 also had Father [[spoiler:who is his EvilUncle]] and Chad aka Numbuh 274, the former leader of the KND [[spoiler:who hated him because Numbuh 1 was considered to be a better operative than him (which was eventually proven true).]] Numbuh 2 had Mr. Fizz and Mushi Sanban, Numbuh 3 has Mr. Boss, Numbuh 4, the [[IneffectualSympatheticVillain Toiletnator]] and [[TheBully Ernest]], and Numbuh 5 has her sister Cree.

* In ''WesternAnimation/{{Amphibia}}'', Anne Boonchuy has [[Characters/AmphibiaKingAndrias King Andrias]]. While his antagonism doesn't come apparent to her until over halfway through the season, the king quickly earns Anne's hatred when he tries to kill Sprig by dropping him from his floating castle, and remorselessly stabs Marcy Wu when she used the Calamity Box to create a portal to Earth. The repeated attempted assassinations and Earth invasion plan only make this enmity worse. The fact that Anne ends up the only one who can really do anything about his plans makes this relationship mutual, especially in the FinalBattle where she expresses sympathy over his situation of losing his friendships while she restored hers. [[spoiler: Despite Andrias ultimately surrendering peacefully, she still makes it clear that she will never forgive him since he had his chances to stop.]]

* In ''WesternAnimation/{{Amphibia}}'', [[Characters/AmphibiaAnneBoonchuy Anne Boonchuy]] has [[Characters/AmphibiaKingAndrias King Andrias]]. While his antagonism doesn't come apparent to her until over halfway through the season, the king quickly earns Anne's hatred when he tries to kill Sprig by dropping him from his floating castle, and remorselessly stabs Marcy Wu when she used the Calamity Box to create a portal to Earth. The repeated attempted assassinations and Earth invasion plan only make this enmity worse. The fact that Anne ends up the only one who can really do anything about his plans makes this relationship mutual, especially in the FinalBattle where she expresses sympathy over his situation of losing his friendships while she restored hers. [[spoiler: Despite Andrias ultimately surrendering peacefully, she still makes it clear that she will never forgive him since he had his chances to stop.]]

* In ''WesternAnimation/GravityFalls'', Gideon Gleeful and [[spoiler:Bill Cipher]] are archenemies to [[Characters/GravityFallsDipperPines Dipper Pines]] and, in broader strokes, the rest of the Pines family.

* In ''WesternAnimation/GravityFalls'', Gideon Gleeful and [[spoiler: [[Characters/GravityFallsBillCipher Bill Cipher]]]] are archenemies to [[Characters/GravityFallsDipperPines Dipper Pines]] and, in broader strokes, the rest of the Pines family.

** Eda Clawthorne and [[Characters/TheOwlHouseLilithClawthorne Lilith Clawthorne]] had not seen eye to eye for years largely because of Lilith working for the Emperor's Coven. Worse, "Agony of a Witch" reveals that [[spoiler: Lilith cursed Eda]] so she could have a likelier chance to win a position. Lilith had to do ''a lot'' to regain her relationship with her sister.

** [[Characters/TheOwlHouseEdaClawthorne Eda Clawthorne]] and [[Characters/TheOwlHouseLilithClawthorne Lilith Clawthorne]] had not seen eye to eye for years largely because of Lilith working for the Emperor's Coven. Worse, "Agony of a Witch" reveals that [[spoiler: Lilith cursed Eda]] so she could have a likelier chance to win a position. Lilith had to do ''a lot'' to regain her relationship with her sister.

* ''WesternAnimation/Ben10'' has several characters possessing their own arch-enemies:
** [[Characters/Ben10BenTennyson Ben Tennyson]] has many contenders to the title, but his greatest enemy of all is [[Characters/Ben10Vilgax Vilgax]], by virtue of being by far the oldest and most persistent (he already was an ArchEnemy to Ben's ''grandfather''), as well as having a direct connection to Ben's OriginStory, and appears in all series as an antagonist, which extends to the reboot where he is treated as the most serious and dangerous threat to him of all. In fact, even when faced with the EldritchAbomination Dagon, Ben's main concern was Vilgax. Aside from Vilgax, however, Ben's greatest enemies include;
*** Zs'Skayr, the consciousness hidden within Ben's [[OurGhostsAreDifferent Ghostfreak]] transformation, served as one for the level of grudge he has with Ben as an EnemyWithout and the general intensity of their schemes and battles, to the point Ben formed an EnemyMine with ''Vilgax'' at one point to confront him.
*** [[MadScientist Dr. Animo]], Ben's most recurring human enemy, who [[OvershadowedByAwesome ended up overshadowed by more dangerous foes]], but would remain a thorn in Ben's side until at least his 40s. In fact, when getting the Negative 10 to start infighting, Ben shows an uncharacteristic WorthyOpponent feeling toward Animo by feeling he should be "next in charge" of the group.
*** [[EvilCounterpart Kevin 11]] served as Ben's antithesis in their childhood, in the way he used his powers for his selfish desires and eventually mutated into a hybrid form of Ben's aliens, but made a HeelFaceTurn when they became teenagers, becoming best friends, with Ben even calling Kevin the brother he never had by "Ultimate Alien". He was replaced as Ben's antithesis by Albedo, Azmuth's former assistant trapped in the form of a [[EvilTwin color-inverted version]] of Ben, who is treated as more of a HarmlessVillain than Kevin was, though still attempting to prove his worth by the manner of being the creator of the Ultimatrix.
*** The rogue Galvanic Mechamorph Malware would serve as another personal adversary for Ben, with Ben even fearing him due to him destroying Feedback, essentially killing a part of Ben and being implied to be the reason he removed the Omnitrix in the TimeSkip between series.
*** The above competitors for the status as one of Ben's arch-enemies also vary greatly in how Ben treats them. Ben treats Animo more or less as a persistent but lower-tier villain by the events of ''Ultimate Alien'', but he does ''not'' extend this to Kevin or Malware: When Kevin went insane again and became even more dangerous than before as Ultimate Kevin, Ben more or less spent the entire period in crisis mode and was a lot quicker to use extreme tactics to take Kevin down no matter the costs as, not just a great villain returning, but a personal failing he needed to correct. Meanwhile, despite debuting in the lighter ''Omniverse'' series, neither Ben nor the narrative ever treat Malware or the threat he poses as a joke.
** Gwen Tennyson has Hex and Charmcaster, both being directly linked to her connection to magic. While both of them ''did'' fight Ben, it's pretty clear their grudge toward Gwen is much more personal. Hex ends up undergoing a HeelFaceTurn in ''Omniverse'', leaving Charmcaster as Gwen's sole main antagonist (Charmcaster herself has been going through the HeelFaceRevolvingDoor since ''Ultimate Alien'', but has performed enough villainous acts to still qualify).
** While Ragnarok appeared for only one episode, his link to Kevin's origin is enough to qualify as Kevin's Arch-enemy. In ''Omniverse'', Kevin gains a new recurring one in Proctor Servantis, another villain with major ties to Kevin's backstory [[spoiler:and who implanted false memories into Kevin and the Plumbers' kids to get them close to Ben, with the aforementioned Ragnarok ultimately turning out to be one of Servantis' allies]].
** Rook Blonko has his former master Kundo, who hates Rook's use of technology and breaking of old Revonnahgander traditions by leaving Earth. Their conflict becomes truly personal when Rook finds out Kundo had injured his father while trying to stop his sister leaving Revonnah.
** AntiVillain King George from the Forever Knights had [[EldritchAbomination Dagon]]. The Forever Knights' ideology towards persecuting aliens is rooted in their conflict with Dagon (even chronicled in history as ''Literature/SaintGeorgeAndTheDragon''), and their ultimate mission is to prevent Dagon's return.
** Professor Paradox has fellow time traveler Eon, a rogue alternate version of Ben who has sought many times to conquer or destroy time, even stealing Paradox's Chrono-Navigator at one point in an attempt to achieve this.

*** Zs'Skayr for the level of grudge he has with Ben as an EnemyWithout and the general intensity of their schemes and battles.
*** [[MadScientist Dr Animo]], Ben's most recurring human enemy, who [[OvershadowedByAwesome ended up overshadowed by more dangerous foes]], but would remain a thorn in Ben's side until at least his 40s. In fact, when getting the Negative 10 to start infighting, Ben shows an uncharacteristic WorthyOpponent feeling to Animo by feeling he should be "next in charge" of the group.
*** [[EvilCounterpart Kevin 11]] served as Ben's EvilCounterpart in their childhood, but made a HeelFaceTurn when they became teenagers, becoming best friends, with Ben even calling Kevin the brother he never had by "Ultimate Alien". He was replaced as the EvilCounterpart by Albedo, Azmuth's former assistant, who is treated more as a HarmlessVillain than Keven was.
*** Malware, who Ben has a personal grudge against, and fear of, due to him destroying Feedback, essentially killing a part of Ben and implied to be the reason he removed the Omnitrix in the TimeSkip between series.
*** The above competitors for the status as one of Ben's arch-enemies also vary greatly in how Ben treats them. Ben treats Animo more or less as a persistent but lower-tier villain by the events of ''Ultimate Alien'', but he does ''not'' extend this to an Kevin or Malware: When Kevin went insane again and became even more dangerous than before as Ultimate Kevin, Ben more or less spent the entire period in crisis mode and was a lot quicker to use extreme tactics to take Kevin down no matter the costs as, not just a great villain returning, but a personal failing he needed to correct. Meanwhile, despite debuting in the lighter ''Omniverse'' series, neither Ben or the narrative ever treat Malware or the threat he poses as a joke.

** While Ragnarok appeared for only one episode, his link to Kevin's origin is enough to qualify as Kevin's Arch-enemy. In ''Omniverse'', Kevin gains a new recurring one in Proctor Servantis, another villain with major ties to Kevin's backstory [[spoiler:and who implanted false memories into Kevin and the Plumbers' kids to get them close to Ben]].

** AntiVillain King George from the Forever Knights had [[EldritchAbomination Dagon]].
** Professor Paradox has fellow time traveler Eon.

** Hiccup Horrendous Haddock III had Dagur the Deranged, who sought vengeance on him after learning he deceived Dagur. Dagur eventually loses the position of Hiccup's archenemy to Viggo Grimborn, one of the few people capable of outsmarting Hiccup.

** Ron Stoppable's Arch Foe is Monkey Fist, but that's mostly because Fist is the only one who recognizes Ron's name; that and the "Mystical Monkey Power."

** Although the show works on a MonsterOfTheWeek format that discourages recurring enemies, [[TheHighQueen Princess]] [[BigGood Celestia]] is only ever shown to have personal animosity towards one individual: [[GodOfEvil Discord]]. He was the first character Celestia ever actually sent the Mane Six to defeat, and [[OoCIsSeriousBusiness the first time we ever see her angry or genuinely surprised]] are when he steals the Elements of Harmony. [[ForTheEvulz He, of course, thinks this is all great fun.]] [[spoiler:Now that Discord has pulled a HeelFaceTurn, this probably no longer applies, even if he's still a loose cannon.]]

** Spike and Garble have an intense, personal, and mutual hatred of each other -- Spike hates Garble for being a violent bully, and Garble hates Spike for being a CategoryTraitor. All three of Spike's trips to the Dragon Lands have had him put Garble in his place. [[spoiler:His fourth trip ends with the two burying the hatchet.]]
** Applejack, the living embodiment of honesty, has a heated rivalry with {{Snake Oil Salesm|an}}en Flim and Flam. It doesn't help that at least two of their cons have involved personally screwing over her and her family.
** For the Mane Six as a whole, Queen Chrysalis is the most prominent threat who refuses to either a. [[HeelFaceTurn turn good]] or b. [[KilledOffForReal stay down]].
** Discord and Tirek both share an intense, mutual hatred. Tirek took great pleasure in manipulating and betraying Discord. Discord is the one who seals Tirek’s ultimate fate of being turned into stone. And it’s implied that the two of them have met long before and not on good terms.

** Eda and Lilith Clawthorne had not seen eye to eye for years largely because of Lilith working for the Emperor's Coven. Worse, "Agony of a Witch" reveals that [[spoiler: Lilith cursed Eda]] so she could have a likelier chance to win a position. Lilith had to do ''a lot'' to regain her relationship with her sister.

** Luz and Emperor Belos. This is sealed when Luz [[spoiler: uses fire glyphs to destroy the portal to the human world]] thus earning Belos' fury. Their further encounters in the second season only make this worse, as Luz has to [[spoiler: live with the realization she helped Belos rise to power in a stable time loop]] while Belos [[spoiler: gets tricked and branded by Luz in the Season 2 finale, putting him at risk of his own genocide plan]].
** Amity's relationship with her mother [[EvilMatriarch Odalia]] was always tense, but Amity disowns her in the season 2 episode "Clouds On The Horizon" when Odalia [[spoiler: reveals that she is backing Belos in achieving the Day of Unity under the notion that she (primarily) and her family would rule as lesser royalties in the new world]]. She also finds out that Amity [[spoiler: was dating Luz and tries to drive a wedge into it]].

* Perry the Platypus and Dr Doofenshmirtz from ''WesternAnimation/PhineasAndFerb'' are acknowledged to be this, though Perry likely doesn't really respect Doofenshmirtz as a nemesis. Even so, the relationship is very important to both of them, and any time it's interrupted is [[DoesThisRemindYouOfAnything treated like a romantic break-up]].

* ''WesternAnimation/RickAndMorty'': The Council of Ricks and the Galactic Federation for Rick Sanchez C-137.

** Rick also has Evil Morty, TheManInFrontOfTheMan to Evil Rick, the first person to hack into Rick's portal gun. [[spoiler:Evil Morty later hacks into Rick's portal gun again, preventing him from teleporting, and leaves Rick and Morty stranded in space until they are rescued by Space Beth.]]

* ''WesternAnimation/SamuraiJack'': Jack's arch-enemy is the shapeshifting demonic BigBad Aku, who is responsible for both destroying Jack's old kingdom and killing his father, as well as flinging him into the BadFuture where Aku believed he would have no trouble dispoosing of the "FOOLISH SAMURAI!". Deconstructed in Season 5, where it's shown that both have gotten plain tired from being in a stalemate for the last 50 years.

* ''WesternAnimation/SheRaAndThePrincessesOfPower'': Adora and Catra. The two were raised together, and are functionally sisters in all but blood, but the manipulations of their mother-figure [[AbusiveParents Shadow Weaver]] left a ''lot'' of deepset issues between them. Namely, that Adora feels anything Catra does is her responibility, while Catra believes she's AlwaysSecondBest to Adora. After Adora's HeelRealization and defection to the Rebellion, Catra feels personally betrayed, and becomes increasingly determined to finally "win" over Adora, no matter the cost, even sacrificing her chance to start a new life as a crime-lord in the Crimson Wastes where everyone admired her strength. This finally reaches it's breaking point in the Season 3 finale when [[spoiler:Catra triggers TheEndOfTheWorldAsWeKnowIt just so she can ''finally'' "beat" Adora at something, with only Queen Angella's HeroicSacrifice preventing it]]. After that, Adora makes it clear that whatever their previous relationship may have been, Catra's dead to her now.

** Bart Simpson has several archenemies, varying from simple school rivalries with fellow students and teachers to much more serious life-and-death scenarios:

** Homer's archenemies are Mr. Burns, Ned Flanders, Frank Grimes, and Patty and Selma.
** Although with Grimes it's mainly one sided, Homer seemed to actually quite like him. It's also one-sided with Homer and Flanders, since Flanders considers him to be a close friend.
** Homer has also repeatedly come into conflict with the mob boss Fat Tony. In ''Homie the Clown'', Tony mentions that Homer once "crashed his car through the wall of [his gang's] club." In ''Mayored to the Mob'', Homer learns Fat Tony is secretly selling rat milk to the school his children attend. Homer convinces Mayor Quimby to shut down the operation, and later foils Tony's attempt to have Quimby assassinated in retaliation. In ''Poppa's Got a Brand New Badge'', Homer establishes a security company which arrests Fat Tony, who tries to kill Homer in retaliation. In ''Donnie Fatso'', Homer infiltrates Fat Tony's syndicate on behalf of the FBI. [[spoiler:Fat Tony dies of a heart attack after discovering Homer's betrayal.]]

* [[WithFriendsLikeThese Cartman and Kyle]] from ''WesternAnimation/SouthPark''. It was mostly onesided on Cartman's side earlier on, but the two snowballed into mortal enemies somewhere in the fifth season, and has jumped up a notch with every subsequent season. Cartman even acknowledges that he and Kyle are arch enemies in "Grounded Vindaloop".

** Cartman's alter-ego the Coon is this to Mysterion (Kenny).
** Stan Marsh's Arch Enemy is his abusive sister, Shelley, until she gets overshadowed by their father Randy, who becomes the Arch Enemy for both of them. In ''[[Recap/SouthParkS16E12ANightmareOnFaceTime A Nightmare on Face Time]]'', Randy forces his family to work at a Blockbuster store he bought, which prevents Stan from trick-or-treating. Shelley ends up burning the store down. In Season 22, Randy uproots him family from South Park so [[ItsAllAboutMe he can become a weed farmer]], which eventually causes so much friction between Randy and the rest of the family that by the time of the Season 23 episode ''[[Recap/SouthParkS23E6SeasonFinale Season Finale]]'', Stan, Shelley, and their mom/Randy's wife Sharon [[AndThereWasMuchRejoicing celebrate Randy's arrest]]. In the BadFuture of Season 24, Stan burns Tegridy Farms down, accidentally killing Shelley in the process, which [[DrivenToSuicide drives Sharon to suicide]], with Stan and Randy both [[NeverMyFault blaming each other for their deaths]].

** For the series ''WesternAnimation/AvatarTheLastAirbender'', Avatar Aang's challenge was the burden of responsibility and the concept of war. His villain was Fire Lord Ozai, though the conflict was not personal for Aang. The {{deuteragonist}} Prince Zuko was pushed to see the Avatar as his arch-enemy, the obstacle whose defeat would supposedly allow him to reenter his father's good graces. However Zuko's conflict was also an internal one of ethics versus expectations. Character development for both Aang and Zuko meant [[spoiler:confronting the Fire Lord as a proxy for confronting themselves]].
*** Zuko has an antagonistic relationship with younger sister Azula. [[spoiler:She becomes Zuko's final opponent in the series, while Aang is confronting Ozai.]]
** ''WesternAnimation/TheLegendOfKorra'' follows an arc villain format, where each of the four seasons represents a different conflict and lesson for Korra. Amon was [[spoiler:an inherited grudge from an enemy of Avatar Aang,]] though even for him the personal conflict wasn't the center of his purpose. Zaheer and the Red Lotus were opposed to the concept of the Avatar, and authorities itself, and while they also were not personal, they left a long term psychological impact. Kuvira is directly referred to as Korra's {{foil}}, and was meant to embody a possible post-Avatar world. However the most personal and consistent nemesis of Korra, who ''did'' have a personal grudge against her, was her uncle, Unalaq:

** Ben Tennyson has many contenders to the title, but his greatest enemy of all is Vilgax, by virtue of being by far the oldest and most persistent (he already was an ArchEnemy to Ben's ''grandfather''), as well as having a direct connection to Ben's OriginStory, and appears in all series as an antagonist, which extends to the reboot where he is treated as the most serious and dangerous threat to him of all. In fact, even when faced with the EldritchAbomination Dagon, Ben's main concern was Vilgax. Aside from Vilgax, however, Ben's greatest enemies include;

** Bob has [[{{Jerkass}} Jimmy Pesto]], Bob's business rival who frequently one-ups him. He also has one in [[ObstructiveBureaucrat Hugo Habercore]], the city health inspector who aims to get the restaurant shut down after Linda left him for Bob. That said, it's more one-sided on Hugo's end.
** Louise has guidance councilor [[ChildHater Phillip Frond]], with his ideas always making her school life harder.

* In the Franchise/DCAnimatedUniverse, ComicBook/LexLuthor is still Franchise/{{Superman}}'s primary enemy, but {{ComicBook/Darkseid}} and [[OmnicidalManiac Brainiac]] [[EvilerThanThou surpass]] him whenever they show up.

** The Joker and Batman in ''WesternAnimation/BatmanTheAnimatedSeries'' , its sequels, and ''Justice League''. Unlike the contemporary comics, where their battle is more or less [[ComicBookTime destined to go on forever]] (or at least until the next ContinuityReboot), the Franchise/DCAnimatedUniverse actually gets to show their rivalry from its early beginnings all the way to the inevitable, brutal final battle. The notion of an archenemy is also deconstructed; whereas Joker early on seems to hold Batman in high regard as a genuine WorthyOpponent, by the time of their final battle he openly admits to have grown utterly tired of their "game". Bruce himself also has no delusions about what kind of person Joker really was, and tells his successor as much decades after Joker's death.

** Blight to Terry [=McGinnis=] in ''WesternAnimation/BatmanBeyond''. Blight is the supervillain alter ego of [[BigBad Derek Powers]], a CorruptCorporateExecutive who took over Wayne Enterprises and had Terry's father murdered, therefore motivating him to take up Bruce Wayne's mantle and [[CreateYourOwnHero become Powers' greatest enemy]].

* In ''WesternAnimation/DuckTales1987'' Scrooge [=McDuck=]'s arch [[TheRival rival]] is Flintheart Glomgold, but his most threatening nemesis is Magica de Spell. If you have to have an obsessive, [[ImplacableMan implacable]] arch nemesis, might as well be a sexy sorceress.

** With the reveal of him being the head of F.O.W.L. Bradford Buzzard, the former chairman of Scrooge's board of directors, have become one of, if not the, big nemesis for Scrooge. Unlike with his other nemesis Scrooge does treat Bradford very seriously due to how well Bradford knows him and his secrets, to the point that he doubts for a time that he can win against him. Later it is revealed that Bradford is the one who arranged for Della to learn about the Spear of Selene and get lost into space, cementing him as Scrooge's most personnal and hated enemy.

** Ernie the Giant Chicken and Carter Pewterschmidt to Peter Griffin. Though the latter is sometimes mutual and sometimes one-sided (on Carter's part).
** Glenn Quagmire to Brian. They eventually patch things up, though there's still some lingering friction between them.

** Stewie's arch enemy was his half brother Bertram, [[spoiler: up until he was KilledOffForReal]]. You could also make a case for Lois Griffin, who Stewie was [[AntagonisticOffspring hellbent on killing]] in early seasons.

* In ''WesternAnimation/GravityFalls'', Gideon Gleeful and [[spoiler:Bill Cipher]] are archenemies to Dipper Pines and, in broader strokes, the rest of the Pines family.

* ''WesternAnimation/InvaderZim'': Zim has Dib Membrane. Zim is an alien trying to TakeOverTheWorld, and Dib seeks to expose him.

** Ladybug and Cat Noir have a collective one in Hawk Moth, who seeks to take their Miraculouses and use their power to achieve a world-altering wish. For the latter he also doubled as a ArchnemesisDad, though neither father or son are aware of this.
** Ladybug/Marinette also has Lila Rossi, who despises both of her identities despite not knowing they are the same person. Both of them have crushes on Adrien, which led to Lila developing a vendetta against Ladybug for exposing her lies to him, and when Marinette made it clear she wouldn't take any of Lila's verbal bait, she sought to turn all of her friends against her, at one point even getting Marinette expelled.

** Zane has [[SmugSnake General Cryptor.]]

* ''WesternAnimation/AdventureTime'': The Lich for Billy and Finn the Human.
** Also, the Ice King for Finn and Jake in the first two seasons, from later seasons Fern would then also be this. Martin making a good case for this as well.

** For Princess Bubblegum, it's something of a draw between The King of Ooo and Gumbald.

** Gumball Watterson, and to a lesser extent, Darwin, have Rob. In fact, he became Gumball's Archenemy because he had no other role to fulfill as the Universe deemed him a mistake. He [[CreateYourOwnVillain blames Gumball]] for this, [[NeverMyFault even though he had nothing to do with Rob's predicament]].

* In ''WesternAnimation/{{Amphibia}}'', Anne Boonchuy has King Andrias. While his antagonism doesn't come apparent to her until over halfway through the season, the king quickly earns Anne's hatred when he tries to kill Sprig by dropping him from his floating castle, and remorselessly stabs Marcy Wu when she used the Calamity Box to create a portal to Earth. The repeated attempted assassinations and Earth invasion plan only make this enmity worse. The fact that Anne ends up the only one who can really do anything about his plans makes this relationship mutual, especially in the FinalBattle where she expresses sympathy over his situation of losing his friendships while she restored hers. [[spoiler: Despite Andrias ultimately surrendering peacefully, she still makes it clear that she will never forgive him since he had his chances to stop.]]
* ''WesternAnimation/AmericanDad'' Stan has his high school bully Stelio Kontos.

** Played for laughs with one of Roger's more infamous personas, Ricky Spanish. One episode revealed that another of Roger's personas, Jeannie Gold, is not only his arch enemy, but also...his sister!

** Sterling Archer has Barry Dylan. Barry worked for the agency's rival ODIN and had prior grude against Archer for droping him off a building. [[spoiler: After he's turned into a cyborg, Barry kills both Archer's fiancée and the mostly likly candidate to be Archer's father. Weridly, after several years of tring to kill each other, they actual bury the hatchet in season 11]].
** Archer gets a new arch enemy in season 12 in the form of Fabian Kingsworth, the head of IIA. Not only does Fabian routinely mock Archer and try to steal the agency's work, but he also [[spoiler:kidnaps Archer and brainwashes Barry in his attempts to create a protection rack against the entire world]].

** Ben Tennyson's most well known nemesis is Vilgax, by virtue of being by far the oldest and most persistent (he already was an ArchEnemy to Ben's ''grandfather''), as well as having a direct connection to Ben's OriginStory, and appears in all series as an antagonist, which extends to the reboot where he is treated as the most serious and dangerous threat to him of all. Just below Vilgax are five other villains who have similarly intense animosities with Ben at one point or another.
*** [[EvilCounterpart Kevin 11]] and [[MadScientist Dr Animo]] were considered candidates as well in the original show, but by the sequels, Kevin made a HeelFaceTurn, and [[OvershadowedByAwesome Animo ended up overshadowed by new, more dangerous foes]]. They were replaced in competition with Vilgax for the title of being a Arch-enemy of Ben's with Albedo (who replaced Kevin as Ben's EvilCounterpart due to Kevin's redemption and also for having a connection to Ben's origin as Azmuth's former assistant) and Malware in Omniverse (who Ben has a personal grudge against as the one who destroyed Feedback). While not as frequently appearing as any of the above others, Ghostfreak/Zs'Skayr is also considered a candidate for the title for the level of grudge he has with Ben as an EnemyWithout and the general intensity of their schemes and battles.
*** The above competitors for the status as one of Ben's arch-enemies also vary greatly in how Ben treats them. Ben treats Animo more or less as a persistent but lower-tier villain by the events of 'Ultimate Alien' and he is willing to throw shade and jokes at Albedo even as he treats the latter as more dangerous than Animo, he does ''not'' extend this to an evil Kevin or Malware: during ''Ultimate Alien'' where Kevin went insane again and became even more dangerous than before as Ultimate Kevin, Ben more or less spent the entire period in crisis mode and was a lot quicker to use extreme tactics to take Kevin down no matter the costs as not just a great villain returned but a personal failing he needed to correct. Meanwhile, despite debuting in the lighter ''Omniverse'' series, neither Ben or the narrative ever treat Malware or the threat he poses as a joke.
*** The original Ben 10,000 had Dr. Animo regain the title of Arch Enemy by his time period due to his persistence and sheer ''relevancy'': Vilgax was dead and Kevin was trapped in the Null Void and there was no sign of Zs'Skayr. Meanwhile Animo's created minions and persistent ability to escape even the Null Void made him the most persistent thorn in the older Ben's side.
** Gwen Tennyson has Hex and Charmcaster, both being directly linked to her connection to magic. While both of them ''did'' fight Ben, Max or Kevin, it's pretty clear their grudge toward Gwen is much more personal. Hex ends up undergoing a HeelFaceTurn in ''Omniverse'', leaving Charmcaster as Gwen's sole main antagonist (Charmcaster herself has been going through the HeelFaceRevolvingDoor since ''Ultimate Alien'', but has performed enough villainous acts to still qualify).

** Rook Blonko has his former master Kundo, who hates Rook's use of technology and breaking of old Revonnahgander traditions by leaving Earth. Their conflict becomes truly personal when Rook finds out Kundo had injured his father.
** AntiVillain King George from the Forever Knights has [[EldritchAbomination Diagon]].

-->-- A song about '''Perry the Platypus''' and '''Dr Doofenschmirtz''', ''WesternAnimation/PhineasAndFerb'', My Nemesis.

* Perry the Platypus and Dr Doofenschmirtz from ''WesternAnimation/PhineasAndFerb'' are aknowledged to be this, though Perry likely doesn't really respect Doofenschmirtz as a nemesis. Even so, the relationship is very important to both of them, and any time it's interrupted is [[DoesThisRemindYouOfAnything treated like a romantic break-up]].

** ''WesternAnimation/TheVentureBrothers'' has an interesting system wherein archrivalries are assigned, not chosen, by the OSI and Guild of Calamitous Intent (hence the coinage of a term: 'arching' to describe the act of being an archnemesis). In Season 3, it's revealed that a reason for Dr. Mrs. The Monarch's attraction to her husband is that The Monarch's archrivalry of Venture doesn't stem from this stodgy system, but actual, living, breathing, unfounded hatred.

* The Monarch from ''WesternAnimation/TheVentureBrothers'' wants to be Doctor Venture's Arch Enemy, but Doctor Venture doesn't consider him a threat.

''WesternAnimation/GeneratorRex'': Rex Salazar has Van Kleiss, the BigBad of the first two seasons, a supporting antagonist in the third season, [[spoiler:and the killer of Rex's parents.]]

*** Kevin 11 and Dr Animo were considered candidates as well in the original show, but by the sequels, Kevin made a HeelFaceTurn, and [[OvershadowedByAwesome Animo ended up overshadowed by new, more dangerous foes]]. They were replaced in competition with Vilgax for the title of being a Arch-enemy of Ben's with Albedo (who replaced Kevin as Ben's EvilCounterpart due to Kevin's redemption and also for having a connection to Ben's origin as Azmuth's former assistant) and Malware in Omniverse (who Ben has a personal grudge against as the one who destroyed Feedback). While not as frequently appearing as any of the above, Ghostfreak/Zs'Skayr is also considered a candidate for the title for the level of grudge he has with Ben as an EnemyWithout and the general intensity of their schemes and battles.
** The above competitors for the status as one of Ben's arch-enemies also vary greatly in how Ben treats them. Ben treats Animo more or less as a persistent but lower-tier villain by the events of 'Ultimate Alien' and he is willing to throw shade and jokes at Albedo even as he treats the latter as more dangerous than Animo, he does ''not'' extend this to an evil Kevin or Malware: during ''Ultimate Alien'' where Kevin went insane again and became even more dangerous than before as Ultimate Kevin, Ben more or less spent the entire period in crisis mode and was a lot quicker to use extreme tactics to take Kevin down no matter the costs as not just a great villain returned but a personal failing he needed to correct. Meanwhile, despite debuting in the lighter ''Omniverse'' series, neither Ben or the narrative ever treat Malware or the threat he poses as a joke.
*** The original Ben 10,000 had Dr. Animo regain the title of Arch Enemy due to his persistence and sheer ''relevancy'': Vilgax was dead and Kevin was trapped in the Null Void. Meanwhile Animo's created minions and persistent ability to escape capture made him the main thorn in the older Ben's side.

** Grim has Boogey, his high school bully who continues to torment him in the present. Grim also has Jack O'Lantern, who [[DidYouJustScamCthulhu forced Grim to grant him eternal life]] centuries ago, [[DoNotTauntCthulhu causing Grim to retaliate]] by [[OffWithHisHead removing Jack's head]].

** Baron Draxum is Splinter's most personal enemy due to Oroku Saki's role being different. Draxum is the one who mutated him and the Turtles, taking away any chance he had at having a normal life.
** The Foot Clan as a whole remain this way to the Turtles, due to the Lieutenant and the Brute being the most recurring villains in the show and the ones involved in many of the major events, from the Shredder's resurrection to the Kraang invasion.
** The Kraang become this to Leonardo in the movie, especially Kraang One, after Raph is captured during a HeroicSacrifice to save him.