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* ''WesternAnimation/StarWarsTheCloneWars'': In ''[[Franchise/StarWarsLegends Legends]]'', the old ''Star Wars'' ExpandedUniverse, [[DarkActionGirl Asajj Ventress]] was Rattataki and [[spoiler:Darth Maul]] was a pure Zabrak. In this show, they were both {{retcon}}ned into Dathomirians. This is downplayed in Maul's case, as the Dathomirians are a Zabrak subspecies ([[HalfHumanHybrid Zabrak-human hybrids]] in pre-''Legends'' supplementary material), with [[BizarreSexualDimorphism the males looking more like their Zabrak ancestors]], and a lot of characters unfamiliar with Dathomirians assume Maul to be an Iridonian Zabrak as a result.

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* ''WesternAnimation/StarWarsTheCloneWars'': In ''[[Franchise/StarWarsLegends Legends]]'', the old ''Star Wars'' ExpandedUniverse, [[DarkActionGirl Asajj Ventress]] was Rattataki and [[spoiler:Darth Maul]] Darth Maul was a pure Zabrak. In this show, they were both {{retcon}}ned into Dathomirians. This is downplayed in Maul's case, as the Dathomirians are a Zabrak subspecies ([[HalfHumanHybrid Zabrak-human hybrids]] in pre-''Legends'' supplementary material), with [[BizarreSexualDimorphism the males looking more like their Zabrak ancestors]], and a lot of characters unfamiliar with Dathomirians assume Maul to be an Iridonian Zabrak as a result.



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** Mercy Graves was an ordinary human in ''WesternAnimation/SupermanTheAnimatedSeries'' and an Amazon in the comics. Here, she's a HollywoodCyborg.


* ''WesternAnimation/SheRaPrincessOfPower'' has Catra as a human woman who can transform into a feline beast using a magical mask. The 2018 reboot ''WesternAnimation/SheRaAndThePrincessesOfPower'' has her as a PettingZooPerson who regularly exhibits cat-like behaviors.

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* ''WesternAnimation/SheRaPrincessOfPower'' has Catra as a human woman who can transform into a feline beast using a magical mask. The 2018 reboot ''WesternAnimation/SheRaAndThePrincessesOfPower'' has her as a PettingZooPerson who regularly exhibits cat-like behaviors.CatGirl with regular does of FurryReminder.

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* ''WesternAnimation/SheRaPrincessOfPower'' has Catra as a human woman who can transform into a feline beast using a magical mask. The 2018 reboot ''WesternAnimation/SheRaAndThePrincessesOfPower'' has her as a PettingZooPerson who regularly exhibits cat-like behaviors.


** In ''WesternAnimation/RiseOfTheTeenageMutantNinjaTurtles'', the titular four are specific species, and each one's is different. Leonardo is a red-eared slider, Raphael a snapping turtle, Donatello a soft-shelled turtle, and Michaelangelo a box turtle. This becomes more complicated when it turns out ''all'' the {{mutants}} (though made in the same way) are artificial {{youkai}}, and the turtles specifically are also [[MixAndMatchMan artificial]] {{Half Human Hybrid}}s.

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** In ''WesternAnimation/RiseOfTheTeenageMutantNinjaTurtles'', the titular four are specific species, and each one's is different. Leonardo is a red-eared slider, Raphael a snapping turtle, Donatello a soft-shelled turtle, and Michaelangelo a box turtle. This becomes more complicated when it turns out ''all'' the {{mutants}} (though made in the same way) are artificial {{youkai}}, and the turtles specifically are also were [[MixAndMatchMan artificial]] {{Half Human Hybrid}}s.created using]] regular turtles and [[HalfHumanHybrid human DNA]].


** In ''WesternAnimation/RiseOfTheTeenageMutantNinjaTurtles'', the titular four are specific species, and each one's is different. Leonardo is a red-eared slider, Raphael a snapping turtle, Donatello a soft-shelled turtle, and Michaelangelo a box turtle.

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** In ''WesternAnimation/RiseOfTheTeenageMutantNinjaTurtles'', the titular four are specific species, and each one's is different. Leonardo is a red-eared slider, Raphael a snapping turtle, Donatello a soft-shelled turtle, and Michaelangelo a box turtle. This becomes more complicated when it turns out ''all'' the {{mutants}} (though made in the same way) are artificial {{youkai}}, and the turtles specifically are also [[MixAndMatchMan artificial]] {{Half Human Hybrid}}s.


* ''WesternAnimation/IronManArmoredAdventures'' made several of Iron Manís human enemies from the comics like Grey Gargoyle, Dreadknight and Firebrand into ancient creations of the original Mandarin.

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* ''WesternAnimation/IronManArmoredAdventures'' made several of Iron Manís human enemies from the comics like Sunturion, Grey Gargoyle, Melter, Dreadknight and Firebrand into ancient creations of the original Mandarin.

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* ''WesternAnimation/IronManArmoredAdventures'' made several of Iron Manís human enemies from the comics like Grey Gargoyle, Dreadknight and Firebrand into ancient creations of the original Mandarin.


* In ''Anime/{{Voltron}}'', Allura and Coran are [[HumanAliens Arusians]]. In ''WesternAnimation/VoltronLegendaryDefender'', they're the [[LastOfHisKind last of the]] [[RubberForeheadAliens Alteans]]. Note that "Altean" [[DevelopmentGag was what their species was called in]] ''Anime/GoLion'', and ''Legendary Defender'' uses the name "Arusian" for a non-humanoid race. Additionally, [[spoiler: Keith, who was fully human in the original, is now a [[HalfHumanHybrid human/galra hybrid]]]].

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* In ''Anime/{{Voltron}}'', Allura and Coran are [[HumanAliens Arusians]]. In ''WesternAnimation/VoltronLegendaryDefender'', they're the [[LastOfHisKind last of the]] [[RubberForeheadAliens Alteans]]. Note that "Altean" [[DevelopmentGag [[MythologyGag was what their species was called in]] ''Anime/GoLion'', and ''Legendary Defender'' uses the name "Arusian" for a non-humanoid race. Additionally, [[spoiler: Keith, who was fully human in the original, is now a [[HalfHumanHybrid human/galra hybrid]]]].


* In ''Anime/{{Voltron}}'', Allura and Coran are Arusians. In ''WesternAnimation/VoltronLegendaryDefender'', they're the [[LastOfHisKind last of the Alteans]]. Additionally, [[spoiler: Keith, who was fully human in the original, is now a HalfHumanHybrid]].

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* In ''Anime/{{Voltron}}'', Allura and Coran are Arusians. [[HumanAliens Arusians]]. In ''WesternAnimation/VoltronLegendaryDefender'', they're the [[LastOfHisKind last of the the]] [[RubberForeheadAliens Alteans]]. Note that "Altean" [[DevelopmentGag was what their species was called in]] ''Anime/GoLion'', and ''Legendary Defender'' uses the name "Arusian" for a non-humanoid race. Additionally, [[spoiler: Keith, who was fully human in the original, is now a HalfHumanHybrid]].[[HalfHumanHybrid human/galra hybrid]]]].


** In ''WesternAnimation/RiseOfTheTeenageMutantNinjaTurtles'', the titular four will become different turtle species. Leonardo, Raphael, Donatello and Michaelangelo are now respectively a red-eared slider, a snapping turtle, a soft-shelled turtle and a box turtle.

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** In ''WesternAnimation/RiseOfTheTeenageMutantNinjaTurtles'', the titular four will become different turtle species. Leonardo, Raphael, Donatello are specific species, and Michaelangelo are now respectively each one's is different. Leonardo is a red-eared slider, Raphael a snapping turtle, Donatello a soft-shelled turtle turtle, and Michaelangelo a box turtle.

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* ''WesternAnimation/{{Arthur}}'':
** Originally, in the ''Literature/{{Arthur}}'' books, the Tibbles and their grandmother were humans. In the animated series they are bears.
** Applies to Arthur's second grade teacher Mr. Marco. In the books, he was a moose; in the cartoon, he's an aardvark.
* In Marvel Comics, Iron Man villain the Ghost is a human in a high-tech stealth suit. The ''WesternAnimation/AvengersAssemble'' version starts out as this, before turning out to be an Inhuman and gaining innate phasing abilities through terragenesis.
* ''WesternAnimation/{{Bunnicula}}'':
** Potentially. In the ''Literature/{{Bunnicula}}'' books it is suggested that Chester is an UnreliableNarrator and Bunnicula is a normal rabbit. The cartoon makes it clear that he is a vampire.
** Chester's breed was changed. In the books he is a tabby but in the cartoon he is a Siamese cat.
* ''WesternAnimation/{{Curbside}}'' curiously changed Creator/{{Terrytoons}} characters WesternAnimation/HeckleAndJeckle from magpies to crows, though they don't look too different from their usual depictions.
* ''Franchise/DCAnimatedUniverse'':
** The Imperium, the alien invaders from the first three episodes of ''WesternAnimation/JusticeLeague'', are heavily based on the White Martians from the comics. Instead of being actually ''from'' Mars, they're a species of unknown origin who invaded Mars and wiped out [[LastOfHisKind all but one]] of the natives inhabitants years ago.
** In ''Justice League Unlimited'', Brimstone is a nuclear-powered robot built by the military of a fictional Asian country instead of an artificial being created by Comicbook/{{Darkseid}}.
** ''WesternAnimation/SupermanTheAnimatedSeries'' changed ComicBook/{{Brainiac}} into a Kryptonian AI, instead of the Coluan he is in the comics.
* ''Franchise/GIJoe'':
** While originally seemingly human, ''WesternAnimation/GIJoeTheMovie'' retconned Cobra Commander into a snake person from the ancient civilization of Cobra-La. Fans and Creator/LarryHama, who helped create the characters for [[ComicBook/GIJoeARealAmericanHero the comics]] and cartoon (even writing the original version of the former) hated the Cobra-La origin and every other iteration has kept the Commander human.
** Serpentor is still genetically-engineered by Dr. Mindbender in ''WesternAnimation/GIJoeRenegades''--only this version is a giant snake, not a man.
* In ''WesternAnimation/HulkAndTheAgentsOfSMASH'', Sauron is an intelligent pterosaur from the Savage Land (and he's seen in the prehistoric era in "Days of Future Smash"). In the comics he was a human called Karl Lykos who was bitten by a Savage Land pterosaur, and mutated into intelligent-pterosaur form.
* ''WesternAnimation/IronMan'' changed Firepower from a man in a MiniMecha to a robot.
* In ''WesternAnimation/LoonaticsUnleashed'', even though the main characters are all {{Funny Animal}}s of the same species as their [[WesternAnimation/LooneyTunes ancestors]], there are characters based on (and sharing the surnames of) Pepe Le Pew and Foghorn Leghorn who are human.
* There's a ''WesternAnimation/LooneyTunes'' short where Goldilocks is a mouse and the Three Bears are replaced with the Three Cats (Sylvester and his family).
* ''Franchise/MyLittlePony'':
** ''WesternAnimation/MyLittlePonyFriendshipIsMagic'':
*** In G1, Scorpan was a human [[BalefulPolymorph turned into a monster by Tirek]]. The G4 Scorpan is a natural-born Gargoyle.
*** In G1, Somnambula was a human witch. In G4, she is a pegasus.
*** Numerous pony characters from previous gens have their types changed. For example, Rainbow Dash was an Earth Pony in G3 but is a pegasus in G4.
** ''WesternAnimation/MyLittlePonyTales'' featured the first canon appearance of {{Winged Unicorn}}s in the franchise. The episode "Up, Up and Away" features the Glow 'n Show Ponies as having both horns and wings, despite the fact they were all either pegasus and unicorns in the toyline.
* ''WesternAnimation/TheOddballCouple'', a SaturdayMorningCartoon with a cat & dog living together ''a la'' ''Theatre/TheOddCouple''.
* The remake to ''WesternAnimation/PeaceOnEarth'' changes the squirrels into mice.
* ''WesternAnimation/PhineasAndFerbStarWars'' changes [[MadScientistsBeautifulDaughter Vanessa]] into a Twi'lek (or maybe [[HalfHumanHybrid half-Twi'lek]], if you assume that "[[MadScientist Darthenshmirtz]]" is still her father).
* ''WesternAnimation/SpiderManTheAnimatedSeries'' sees Madame Webb, a {{mutant}} in the comics, reimagined as a cosmic entity like the Beyonder.
* ''WesternAnimation/StarWarsTheCloneWars'': In ''[[Franchise/StarWarsLegends Legends]]'', the old ''Star Wars'' ExpandedUniverse, [[DarkActionGirl Asajj Ventress]] was Rattataki and [[spoiler:Darth Maul]] was a pure Zabrak. In this show, they were both {{retcon}}ned into Dathomirians. This is downplayed in Maul's case, as the Dathomirians are a Zabrak subspecies ([[HalfHumanHybrid Zabrak-human hybrids]] in pre-''Legends'' supplementary material), with [[BizarreSexualDimorphism the males looking more like their Zabrak ancestors]], and a lot of characters unfamiliar with Dathomirians assume Maul to be an Iridonian Zabrak as a result.
* ''Franchise/TeenageMutantNinjaTurtles''
** The Shredder/Oroku Saki was changed [[spoiler: to an Utrom, whose real name was Ch'rell, disguising himself as a human]] in [[WesternAnimation/TeenageMutantNinjaTurtles2003 the 2003 series]]. Although it was eventually revealed that [[spoiler: Oroku Saki was once a real human being who lived during the time of ancient Japan, and became the original Tengu Shredder. Ch'rell simply based his human identity on the original Saki]].
** Splinter was originally the pet rat of his human owner Hamato Yoshi prior to his mutation. In [[WesternAnimation/TeenageMutantNinjaTurtles1987 the 1987]] [[WesternAnimation/TeenageMutantNinjaTurtles2012 and 2012 cartoon]], he was made into a CompositeCharacter where he formerly was Hamato Yoshi himself, before being mutated into a rat.
** Also in [[WesternAnimation/TeenageMutantNinjaTurtles2012 the 2012 cartoon]], [[spoiler: April O'Neill,]] previously a 100% pure-blooded human in most other ''TMNT'' works, is now made [[HalfHumanHybrid half-human, half-Kraang]] due to [[spoiler: being experimented on by them when she was still in her mother's womb.]] Meanwhile, [[spoiler:Irma]] and Agent Bishop, who were humans in the previous TMNT cartoons they appeared in, respectively get changed to a Kraang in disguise and an Utrom.
** In ''WesternAnimation/RiseOfTheTeenageMutantNinjaTurtles'', the titular four will become different turtle species. Leonardo, Raphael, Donatello and Michaelangelo are now respectively a red-eared slider, a snapping turtle, a soft-shelled turtle and a box turtle.
* One of the few things we know about the never fully released ''WesternAnimation/ToonMakersSailorMoon'' is that Luna from ''Manga/SailorMoon'' would have gone from being a black short-haired cat to a white longhaired one.
* ''Toys/TheTrashPack'' Mondo TV Cartoon plays for an...interesting version of this idea. As the core chunk of Trashies are [[AnimateInanimateObject Animate Inanimate Objects]] anyways, Putrid Sardine, originally a can of sardines in the toyline, is instead adapted into a juice box in the cartoon. He still keeps his oozy green juice and dent-formed unibrown, however.
* In ''Anime/{{Voltron}}'', Allura and Coran are Arusians. In ''WesternAnimation/VoltronLegendaryDefender'', they're the [[LastOfHisKind last of the Alteans]]. Additionally, [[spoiler: Keith, who was fully human in the original, is now a HalfHumanHybrid]].
* ''Franchise/XMen'':
** ''WesternAnimation/XMen'' makes a few characters who weren't mutants in the comics into mutants, such as the Purple Man. An inverse example is Silver Samurai, who is a mutant in the comics, but was depicted as a human with a teleportation device in the show.
** ''WesternAnimation/XMenEvolution'' split the difference in relation to the Juggernaut. Instead of a full-blooded mutant (seen in ''X-Men: The Last Stand'') or a man given powers by a magical relic (''X-Men'' comics), Juggernaut was described as having a dormant mutant gene that he "awakened with mysticism".
** Likewise, ''WesternAnimation/WolverineAndTheXMen'' makes Nitro into a mutant. In the comics, he was a normal human who was given superpowers by the Kree. Sauron also makes a cameo appearance in an M.R.D. holding cell in one episode, indicating that he too is a mutant in this continuity.
* ''WesternAnimation/YoungJustice'':
** Black Beetle is a CompositeCharacter with the comic books' Duwar, and is thus a member of the Reach species. In the comics, he's a human who has a Reach [[PoweredArmor scarab]], and at various times has been hinted to [[MultipleChoicePast either]] be [[FutureMeScaresMe a future version]] of [[Comicbook/BlueBeetle Jaime]] or his former friend Hector.
** ComicBook/KlarionTheWitchBoy has a few different backstories in the comics, but is always human (or a WitchSpecies thereof). Here, he's a [[PowersThatBe Lord of Chaos]].
** In the comics by Creator/JackKirby, Forager was heavily implied to be a Comicbook/{{New God|s}} child that had been raised by the gigantic insects that live beneath New Genesis. In the cartoon, he actually ''is'' one of the insects, and has been redesigned to appear less humanoid.

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