These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Harsher in Hindsight: One of the earliest strips is Jeremy musing on how his generation didn't have the life changing events his parents' did (such as the Kennedy assassination and the moon landing). This was before 9/11.
Tear Jerker: Connie sadly looking at Jeremy, while imagining herself "unzipping" his body to reveal his happy childhood self, who proceeds to play with his mom. She looks at the current Jeremy and sighs. Mothers still write in telling the creators it's their favorite strip◊.
We're Still Relevant, Dammit: Averted. Despite the fact that the comic began in 1997, and the creators haven't raised a teenager in quite a while, they're still able to perfectly capture teenage and parent life without feeling like you're watching a rerun from a really old sitcom.