These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
First Installment Wins: Any trouble digesting the ridiculata of the latter seasons will either be soothed or completely exacerbated by the dramatic superiority of pretty much any episode from the first three.
Harsher in Hindsight: The death of Bette's father was followed soon after by the death of the actor, veteran thespian and civil rights leader Ossie Davis. (Those pictures from the funeral with MLK and Bill Clinton weren't Photoshopped.)
Moral Event Horizon: Once they learned that he'd rigged the entire house with surveillance cameras so he could turn the intimate details of his roomates' personal lives into fodder for his next documentary, there was no way in Hell the viewers were ever going to forgive Mark. (Which is probably why he was Put on a Bus between Seasons 2 and 3.)
For some, Jenny crossed this when she repeatedly and cannivingly mocking Max for being transgender, repeatedly calling him "she" and a "mom". She pretends to be confused as to why he is upset. Especially the scene where they celebrate Max being pregnant with the Willy Wonka-themed party. Jenny acted in such a disgusting manner - this was one of the reasons that Max ended up having a severe anxiety attack.
Stealing Alice's idea for a movie script is also a major assholery of hers, even thought she started to cross over earlier than in the sixth season.
Most Annoying Sound: For some, Alice's voice. In the show, Alice for some reason decided to raise the pitch of her voice significantly and make it sound more nasally. She sounded relatively normal early on, but her voice sounds like a nasally chipmunk in later episodes.
Pandering To ThePeriphery Demographic: The show was supposedly aimed at a female audience. However, it garnered a very large straight male fanbase mainly through extensive sex scenes, reducing gay guys to background extras, making one of the girls bisexual (which ensured a straight guy would participate from time to time) and making straight guys prominent in the supporting cast. Actual lesbians didn't miss that and often denounced the whole show because of the blatant pandering.
Protagonist-Centered Morality: All characters get this to some degree, but Bette is easily the worst. Helena would rather donate money to a shelter for single mothers and their children rather than give Bette an art grant? Guess who the romantic antagonist is for the same season.
The Scrappy: Jenny, to somemany almost all viewers. There wasn't a viewer who didn't cringe every time Tonya opened her mouth.
Niki. The party girl closeted lesbian actress who uses a beard and who dates older women. She was based on Lindsay Lohan. This was confirmed as fact by the actress, and the writer Angela Robinson (Who is a lesbian and worked with Lindsay so there may be Reality Subtext there)
Tim, Jenny's ex-girlfriend. He's a very good boyfriend, and he even forgives Jenny after she cheats on him. Poor guy.
Shane. Her Once a Season character arc is her coming from a bad place, somehow managing to rebuild her life, and having it ruined in increasingly dramatic ways. And that's without her frequent Slut Shaming and Dark and Troubled Past...