These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Marie L'Angell is the terrifying grandmother of protagonist Jesse Custer. She takes "controlling" to a new level and views her own family as tools rather than people. Her usual punishment of her grandson Jesse was locking him into an airtight coffin with an air hose and letting him wallow in his own shit and piss for a week. Then, she attempted to kill her daughter Christina for trying to stop it. But the worst of Marie's cruelties is her obsession with "hardening" Jesse by destroying all his non-family ties, including his puppy dog, his girlfriend, and his childhood friend. And his own father.
Jody is generally the instrument of this. Unlike Marie, however, Jody makes no pretense that he doesn't enjoy what he does. We see what a total scumbag he is when he blows Jesse's father's brains out right in front of him and then sneers "fucking crybaby" at a tearful Jesse. When Jesse's dog tries to be friendly to Jody, Jody nails its head to a post and then brutally beats Jesse into submission for it. Years later, Jody forces Jesse to cry 'uncle' while twisting his arm so bad the bone snaps out. In the present times, Jody pulls a repeat again when he shoots Tulip in the head at Marie's request. While Jesse watches. With that smug, superior expression all the while. Later, when Marie finally orders Jesse's death, Jody isn't content with just killing him, oh no. He has to break and humiliate him and make him beg first. When Jesse finally strangles Jody to death, Jody is too twisted to feel anything but pride that his abuses turned Jesse into a killer.
Crosses the Line Twice: More like it crosses the line six times and is still looking for the next line to cross, with no sign of stopping.
God-Mode Sue / Villain Sue (Until his quasi Heel-Face Turn): The Saint. Nothing can kill him and he can kill everything. At least Jessie getting him once with the Word of God showed he wasn't completely invincible.
Harsher in Hindsight: Cassidy's loving tribute to New York City is capped by a city skyline focusing on the World Trade Center, which would be destroyed only a few years after publishing.
HSQ: Just keeps going up and up in the War of the Sun arc. The Saint goes from kicking a tank to being hit with a nuke!
Magnificent Bastard: Herr Starr. Even after being nigh-completely mentally and physically destroyed, he's still just about the baddest motherfucker in the valley. (Okay. Second baddest.)
Unfortunate Implications: Being raped by a gay man will turn you gay yourself — Starr gets raped by a Depraved Homosexual, and loses all sexual interest in women, having to resort to being anally penetrated by whores with strap-on dildos to get sexual release.
Possibly. While Starr fears this, he eventually realizes he still is only attracted to women; the rape however revealed he enjoys receiving anal pleasure, as he's seen engaging in pegging from various whores for the rest of the series (even after he loses his genitals, he states its the closest thing to sexual pleasure he can feel anymore).
The comic was written in the mid-to-late 90s and approaches homosexuality in a way that would raise some eyebrows in today's political atmosphere. Sexual depravity is a major theme in the series, and homosexuality is repeatedly placed in the mix. It's frequently linked with perversity, emasculation and villainy.
Abuse to animals is played for laughs in the early parts of the series. One of our heroes throws a guard dog through a glass window and casually steps over its corpse. Later the gang traps a cat in a toilet, which manages to horrify a pair of deranged murderers. Later in the series, Ennis apparently atones for this theme by having Jesse step in against a dog-beating cop and get a loyal canine companion.
Arseface - his father is an abusive Jerk Ass and most of his peers aren't much better. Then he is horribly disfigured by a botched suicide attempt and it goes downhill from there...
Sally, the homeless woman Jesse encounters who tells him Cassidy's history.
Starr is a villainous example. He Used to Be a Sweet Kid, then a pack of bullies decided to blind him/gouge out his eye by cutting a star into his face, something that also (somehow) left him bald. Then, in the course of the series, he gets raped by a Depraved Homosexual, finds himself unable to be sexually aroused by women anymore and has to resort to being anally penetrated by whores wearing strap-on dildos to get pleasure, gets a scar cut across the top of his head that makes him look like a giant walking penis, gets his genitals bitten off by a dog...