These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Complete Monster: Marie L'Angell is the terrifying grandmother of protagonist Jesse Custer. She takes "controlling" to a new level and views her own family as tools rather than people. Her usual punishment of her grandson Jesse was locking him into an airtight coffin with an air hose and letting him wallow in his own shit and piss for a week. Then, she attempted to kill her daughter Christina for trying to stop it. But the worst of Marie's cruelties is her obsession with "hardening" Jesse by destroying all his non-family ties, including his puppy dog, his girlfriend, and his childhood friend. And his own father.
Jody is generally the instrument of this. Unlike Marie, however, Jody makes no pretense that he doesn't enjoy what he does. We see what a total scumbag he is when he blows Jesse's father's brains out right in front of him and then sneers "fucking crybaby" at a tearful Jesse. When Jesse's dog tries to be friendly to Jody, Jody nails its head to a post and then brutally beats Jesse into submission for it. Years later, Jody forces Jesse to cry 'uncle' while twisting his arm so bad the bone snaps out. In the present times, Jody pulls a repeat again when he shoots Tulip in the head at Marie's request. While Jesse watches. With that smug, superior expression all the while. Later, when Marie finally orders Jesse's death, Jody isn't content with just killing him, oh no. He has to break and humiliate him and make him beg first. When Jesse finally strangles Jody to death, Jody is too twisted to feel anything but pride that his abuses turned Jesse into a killer.
Crosses the Line Twice: More like it crosses the line six times and is still looking for the next line to cross, with no sign of stopping.
Designated Villain: God, until Alamo. The main reason Jesse goes after him is to make God apologise for earth being a Crapsack World even though it's pointed out humans have complete free will and made the world the way it is. However over the course of the comic, God isn't presented as a bad person, really just a coward. In fact he only attacks Jesse for attempting to use the Word, so it's actually self-defence considering Jesse does kill and hurt with slight provocation. It isn't until Jesse's conversation with the Saint at the Alamo that we discover any real crime. God started the war in Heaven and made Earth the way it was just to see who would love him. Also the fact he deliberately fixed things so that the Saint's family would die so he would damn himself and become the Saint.
God Mode Sue / Villain Sue (Until his quasi Heel Face Turn): The Saint. Nothing can kill him and he can kill everything. At least Jessie getting him once with the Word of God showed he wasn't completely invincible.
Possibly justified, given that, well, he's Death. Being unkillable and able to kill anything sort of comes with the job decription.
HSQ: Just keeps going up and up in the War of the Sun arc. The Saint goes from kicking a tank to being hit with a nuke!
Magnificent Bastard: Herr Starr. Even after being nigh-completely mentally and physically destroyed, he's still just about the baddest motherfucker in the valley. (Okay. Second baddest.)
And after Jesse's supposed death, Cassidy gets a broken Tulip hooked on pills and booze so that she'll be totally dependent on him, and has sex with her multiple times whilst she's pretty much completely out of it. And that's before we discover his past. He does feel ashamed about it after, but still...
In all fairness, it's possible he didn't intentionally keep Tulip drugged up for that reason. From what we learn of Cassidy from Sally, it's clear that he has some serious problems with substance abuse and tends to drag his lovers down with him sooner or later. Plus, since they were both under the impression that Jesse was dead and Tulip was completely crushed, he might have though he was helping her deal with the pain in the only way he knows how.
He commits a murder that the victim did not deserve (Sheriff who shot at him for sleeping with his wife). Honestly, what did Cass expect the guy to do? And Cass survived the shot, being a vampire and all. This is the first solid hint that ol' Cass may be more on the side of darkness than light.
On the other hand, shooting someone for sleeping with your wife is pretty bad itself - it would certainly qualify as murder in court. If it were anyone but Cassidy, killing him in self-defense would be completely justified.
Narm: Done deliberately for Arseface. And it works.
Values Dissonance: In the Arseface origin story. Both kids suffer pretty much ever textbook case of bullying, at home and at school, without even a hint of help of escape coming from anyone or anywhere. After they try to kill themselves, resulting in one death and one horrible disfigurement, the survivor gets yelled at: He should just have been tougher!
The Woobie: Arseface - his father is an abusive Jerk Ass and most of his peers aren't much better. Then he is horribly disfigured by a botched suicide attempt and it goes downhill from there...
Sally, the homeless woman Jesse encounters who tells him Cassidy's history.