These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
YMMV: Marvel Super Heroes
Adaptation Displacement: Shuma-Gorath is much more well known from his appearance in this game and the rest of the Marvel series than he is in the comics.
Harsher in Hindsight: Spider-Man's ending, full stop. To elaborate, Spidey comes home from saving the universe and Mary Jane tells him that she's pregnant, with Peter re-assuring her she and the baby are his universe. Then One More Day happened.
Memetic Mutation: Some of Spider-Man's lines, such as, "One for J.J.!" and "Do your job!" (or alternatively, "DO YOUR GODDAMN JOB!") are minor memes in the community.