When the Devil abandons his job and removes evil from the world, God asks Bob to talk him out of it so people's decisions can continue to have moral weight.
Bob: Gee, I don't know that I'm all that comfortable with the idea of going to Hell. God: Oh, for Pete's sake, you've been to Branson, Missouri. It's not that different!
The televangelist from the premiere episode, who promptly kicked Bob out of the TV station upon hearing that none of his ideas would bring in any money.
Fridge Brilliance: In "Bob's Father" the Devil says that he made up Purgatory and that it wasn't true. Purgatory is never mentioned at all in the Bible, so he's almost certainly not lying.
Germans Love David Hasselhoff: The show did not do well in the United States (mostly due to complaints about the content being blasphemous), but it got better reception outside of the U.S., particularly in the U.K.
God's "Pep Talk" to the newborns in the same episode showing how nice God can truly be.
He mentions a few of the kids' fate, one becoming famous, one becoming rich, and one "who is going to love wearing his wife's clothes" all with the same level of kindness and excitement, his tone not changing at all.