- Fake American: The British Robin Atkin Downes as American protagonist Travis Touchdown.
- Fake Irish: The American Quinton Flynn as the Irish Henry.
- Fan Nickname: Mister Sir Henry Motherfucker.
- Hey, It's That Voice!:
- Robin Atkin Downes (Kazuhira Miller, The Medic) is Travis Touchdown.
- Paula Tiso (Lulu, Laughing Octopus) is Sylvia.
- J. Grant Albrecht (The End, Crypto) is Death Metal.
- Quinton Flynn (Raiden) is Henry Cooldown.
- Vanessa Marshall (Olga Gurlukovich, Strangelove) is Dr. Naomi.
- Kimberly Brooks (Ashley Williams) is Shinobu.
- Richard McGonagle (General Grievous, Victor Sullivan) is Dr. Peace.
- Josh Keaton (Ocelot, Spider-Man) is Destroyman.
- Kim Mai Guest (Lady Deathstrike, Mei Ling) is Holly Summers.
- Dee Bradley Baker is Helter Skelter, Letz Shake, and Weller.
- Fred Tatasciore (the Beast of the B&B) is Dr. Shake and Randall Lovikov.
- Kathryn Fiore (Venus) is Bad Girl.
- Mitzi McCall (Power Fist) is Speed Buster.
- Steve Blum (Zadornov, Wolverine, Gene, Amon, Spike Spiegel) is Dark Star.
- James Horan (Wheeljack, Skull Face) is Harvey.
- Paul Nakauchi (Gen Fu) is Thunder Ryu.
- Kari Wahlgren is Jeane.
- No Export for You: Averted with the HD port Heroes Paradise. Ubisoft, the publisher of the original for the Wii, decided not to pick up the HD port for release in North America. Thankfully, Konami has stepped in and will be publishing Heroes Paradise as a PS3 exclusive in the west with PlayStation Move support.
- Playing Against Type: Josh Keaton as Destroyman.
Lyrics to "The Virgin Child Makes Her Wish Without Feeling Anything" (Dr. Peace's song):
Despair, the end of the world
I hear the rising phoenix in my dreams
And the virgin child made her wish upon a star
That night her mother talks no more
Cape of Hope, the end of the dream
A shiny fish splashes in a stream
And the virgin child loses her heart and soul
That night her mother's eyes see no more
When the wind blows
The virgin child's corpse sings a song
Such a pretty melody, never heard before
No more lullabies
The virgin child, smiles from Hell