Adored by the Network: ABC Family, Disney Channel, and Disney XD airs this movie every single month, 2 times in a row. Like ABC Family does the back-to-back presentations, Disney Channel does the limited commercial interruption, and Disney XD does the 8:00-5:00 timeline. Although it is a Universal film, so it won't be only on the Disney-based channels. It will air on NBC (possibly), FX (possibly), Cartoon Network (possibly), USA Network (not the animation type but possibly), MTV (same as USA), Nick (possibly), TBS (possibly), ION Network (possibly), AMC (50/50 chance), Spike, Bravo, TNT, VH-1, Starz, and Enccore. Not to mention Teletoon, HBO, and Cinemax aired this movie also.
According to the DVD extras, Julie Andrews was chosen as Mrs. Gru specifically because, of all well-known actresses, she was the least suitable person to play an evil old woman — so choosing her to do so invoked the Rule of Funny. (She refused the part at first, but was persuaded.)
And GOB Bluth gives himself away pretty easily as Mr. Perkins.
On the other hand, though, did you hear Kenneth as the Tourist Dad at the beginning? No, you did not.
CarlyShay/Megan Parker/Summer Hathaway as Margo. Cosgrove had her voice debut in a 2005 Disney movie Peter Cottontail, but this is her prominently known voice actress feature film.
Mexican moviegoers may notice that the Latin American Gru sounds just like Mike Wozowski with an accent. Or Dr. Chunga.
Spanish moviegoers can see how Florentino Fernández is the voice for both Gru and his mother and the beautiful Ana de Armas (El Internado) plays Margo. You can even notice the accent Ana uses (in an interview she stated how hard it was to say "cisnes" (The Swan Lake is translated as El lago de los cisnes) correctly, because she would normally pronounce the 'c' as an 's').
The man working the carnival game (Aww, somebody's got a frowny face!) is Phineas and Ferb's number-one fan, Irving. Once you hear his voice again, it's pretty easy to connect.
Talking to Himself: In the European Spanish version, actor and humorist Florentino Fernández voices Gru and Gru's mother.
Viral Marketing: NBC is absolutely determined that you remember the title of this film. The judges of Last Comic Standing ended up going into mass Sarcasm Mode after the advertising department forced them to "audition" someone in a minion suit. ("Nice job, whores.") The NBC logo also shows up prominently near the start of the film - Gru stole the Jumbotron from Times Square.
Word of God: The minions are genetically engineered corn kernels. The "genetically-engineered" part of that description, however, might have been retconned, judging by the backstory of Minions.
Gru's first name is Felonious and his birthday is September 28, 1960.