These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
YMMV: Despicable Me
Acceptable Targets: Apparently the shrink ray was created in (and stolen from) North Korea.
Crossing the Line Twice: Most of the visual gags qualify as a child-friendly version of the trope. A rocket landing on a playground? Not funny. A rocket landing on the spinner thing causing it to spin incredibly fast while the children cheer? Hilarious.
Ensemble Dark Horse: The minions. The studio saw this coming, and gave them featured roles in all the promotion.
Dave in particular.
Fan Nickname: Doofenshmirtz: The Movie, with all the similarities the character of Gru has. The critic's nickname Wile E. Coyote Vs. Wile E. Coyote also counts.
"Funny Aneurysm" Moment: The film has a bank that invests in supervillany. Two years after the movie's release, it was revealed that HSBC had been knowingly laundering money for terrorists, drug smugglers, and tinpot dictators the world over.
Jerkass Woobie: Gru himself qualifies as this. Sure, he's a mean guy, but look at all his flashbacks to him as a kid with his mom dismissing his claims that he'll go to the moon (and not being encouraging overall to begin with) and the utterly crushed looks on his little face. Not to mention his reaction to his adopted girls been taken away to keep it from being a distraction to him.
The sequel also revealed that Gru was a social outcast in school. The other kids completely avoided him and feared that if he touches them, they will get "Gruties." Seeing his heartbroken expression from this is just agonizing.
Moral Event Horizon: Surprisingly for a kids' movie, two. Vector when he tries to keep Gru from rescuing Margo from the about-to-explode spaceship, and Miss Hattie when she introduces the "box of shame".
One-Scene Wonder: Miss Hattie and Mr. Perkins only appears in three scenes for the entire movie.
WTH Casting: "Okay, so we have an elderly British professor who's hard of hearing, but serious about his job and does whatever he can to keep our villainous protagonist focused. Which star do we know that has the right voice for that? Peter O'Toole? Jeremy Irons?" "GET ME RUSSELL BRAND!!"