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- A character from Wayne's World acted like a happy drunk, going around saying, "I love you, man!" and hugging people.
- City Lights had a character who was exceedingly friendly and generous when drunk, but tight fisted and mean when sober. The fact that he also tended to black out and not remember what had happened when he was drunk adds to the confusion.
- Vodka was the key for a couple of kisses in The Way He Looks. Upon learning this, Leonardo deliberately tries to get Gabriel drunk again. It also leads Leonardo to tell Giovana about his feelings for Gabriel.
- In To Say Nothing of the Dog, Ned compares the sentimentality that time drops can cause to an Irishman in his cups, or a sober Victorian poet.
- In A Tangled Web, Penny Dark gets drunk in order to convince Margaret to call off their engagement by repulsing her. Unfortunately for him, it makes him sentimental and convinced he really is in love with her. His actions convince her that she can't call it off.
- In the Hoka stories, one alien while drunk goes off in sentimental memories of his youth. Then he shifts to Mean Drunk on seeing a human — or primate, as he puts it.
- In Harry Potter and the Half-Blood Prince, Slughorn and Hagrid get drunk together at Aragog's funeral. This puts Slughorn in a much more relaxed mood (as well as ensuring that he wouldn't remember anything Harry said to him), so that Harry can question him about the covered up memory.
- Raymond Shaw in The Manchurian Candidate becomes both more pleasant and more melancholic when he drinks.
Live Action TV
- In one episode of The King of Queens, Doug notices that Carrie is more friendly when drunk, and encourages her to go out drinking as much as possible.
- In a two-parter episode of Cheers, the minister to perform Woody and Kelly's wedding dies, so they (Sam et. al.) find a minister uncle to perform the ceremony. However, he's drunk, so they sober him up. Then he's not actually nasty, but he refuses to perform the ceremony because he hates marriage. So they get him drunk again.
- In a Friends episode, "Fun Bob" was the life of the party (in an appropriate and functional way) when drunk, but was lethargic and boring when sober.
- According to this article from Cracked, Nikita Khrushchev might have prevented a war by being a friendly, sentimental drunk. Josip Broz Tito had gotten into a serious tiff with Josef Stalin, which led him to keep Yugoslavia outside the Soviet Bloc, and war between the Warsaw Pact and Yugoslavia seemed all but inevitable. Even after Stalin's death in 1953, tensions remained high; when the Soviet and Yugoslav governments arranged a summit meeting in Belgrade in May 1955, the Yugoslavs expected it to be a meaningless farce and set things up so that the Soviet delegation would get drunk in public and embarrass themselves. Get drunk in public they did...but embarrass themselves? On the contrary, Khrushchev got all lovey-dovey and started kissing everyone in sight, and heartily encouraged Tito and the Yugoslavs to get drunk with him at a lavish party at the Soviet embassy, at which Khrushchev kept telling Tito, "Josya, quit being so angry! What a thin-skinned one you are! Drink up and let bygones be bygones." The conference ended a huge success and Soviet-Yugoslav tensions were resolved (although Yugoslavia never did join the Pact, they were at least talked out of making a Bomb).