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Anime & Manga
- In Gundam SEED, the desert tiger has many scenes where he makes coffee out of tubes and bubbling pots and whatnot.
Films — Animation
- In Corpse Bride, Elder Gutknecht creates a sorcerous variant.
Films — Live-Action
- In Back to the Future Part III, Doc Brown has this elaborate machine in his Old West blacksmith shop. Takes up most of the room it's in. When he activates it, the thing huffs and puffs and shakes and finally, after all this ostentatious display, spits out two ice cubes. Effective for the implied humor, but also fairly realistic as creating a refrigeration unit in that time with limited materials and technology would result in a large machine.
Marty: It's... a refrigerator?
- In the new Green Hornet movie, Kato makes apparently extremely good coffee with this big scientific industrial looking machine that he made and only he knows how to use.
- Jake Stonebender, from Spider Robinson's Callahan series, owns a Rube Goldberg contraption that looks a bit like a 50s movie doomsday device. Its sole purpose is to make the perfect cup of coffee.
- Magical version: Potion class in Harry Potter. Blend exotic things in a caldron and make a drinkable mixture.
- The machine that makes Three-Course Meal Chewing Gum in Charlie and the Chocolate Factory works this way.
- Breaking Bad: When Walt first enters the "superlab" of premium science equipment for he best meth production, he asks his new lab partner Gale about the contraption of glassware. It turns out that Gale is just as rigourously scientific about making coffee as he is about anything else. After tasting it, Walt agrees with his methods.
- On M*A*S*H the still in the Swamp was originally this when it was first built.
- In one episode of NCIS, after spending hours manually distilling blood samples during a power outage, Abby uses the same apparatus to brew herself a shot of nonalcoholic whiskey.
- Star Trek: Enterprise. Captain Archer gets caught out on a covert mission to a pre-warp drive civilisation this way. He watches a woman create a liquid from her equipment, and asks in a hushed voice what it is. She gives him a funny look as it's their version of a Spot of Tea.
- On the Looney Tunes short "Hot Crossed Bunny", Bugs Bunny threatens to blow up a Mad Doctor with a mixture of chemicals, but the scientist points out that all he did was prepare a chocolate malt. Bugs drinks it and declares, "I'm a better scientist than I thought."
- The introduction to the 1987 Teenage Mutant Ninja Turtles cartoon has Donatello fiddling with a complex machine that makes him a drink.
- One episode of The Simpsons features a fancy resturant where the food is "deconstructed," and drank out of test tubes, or eaten in bite-sized spheres.
- In Hey Arnold!, Arnold asks if an exotic glass-tube contraption will provide the forensic results they need, and Gerald replies that it's just to make hot chocolate.
- Molecular gastronomy / molecular mixology is the real life version of this; molecular gastronomy combines this with an aversion/subversion (depending on your point of view) of Cordon Bleugh Chef (the ingredients indicate the food shouldn't taste good, but it somehow does).
- Some modern fusion restaurants that don't necessarily have elements of molecular gastronomy in their menu still serve drinks in test tubes or flasks. This is a trend among modern Chinese restaurants, where it is known as "test tube juice" (usually consisting of mixed fruit and vegetable juices) and is served as a kind of dessert.