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- This happened four times in Pokémon:
- The Kanto episode "To Master The Onixpected" had Elite Four member Bruno capture an Onix after pulling out a Sandslash that had been lodged between two segments of its rock body.
- The Sinnoh episode "Faced With Steelix Determination" involved a Steelix going on a mad rage near a village of Bidoof because of some shovels that Team Rocket had accidentally jabbed into its head. Made even worse when it was nearing a large lake during its anger (Steelix are Steel and Ground Pokemon and are weak against water). Fortunately, Ash and the gang, with help from the Bidoof, were able to remove the shovels before Steelix could fall into the lake.
- Later Professor Oak proved his identity by identifying that a Tyranitar had a splinter in its foot. The Tyranitar didn't go on a rampage but its trainer said it had been acting grumpy lately.
- A Best Wishes episode had a wild Gigalith that was terrorizing town while Ash was battling against Unova Champion Alder. Alder then noticed that Gigalith had a nail stuck in its foot so he removed it.
- The boar at the beginning of Princess Mononoke was crazy/evil because of a bullet (or rather the ensuing infection).
- In the Fresh Pretty Cure! movie, Inori/Cure Pine gets stuck in a prehistoric jungle and got chased off by an angry Tyrannosaurus rex. But then, Pine found out that it's just in a rampage because a glass or sorts got stuck in its leg, so being the Kindly Vet, Pine removed that glass thing to calm it down.
- This is essentially the effect of "black gears" in Digimon Adventure and dark rings and dark spirals in Digimon Adventure 02.
- A supernatural variant occurs in Spirited Away. The bathhouse is besieged by a rather grouchy stink spirit; while it's in the bath, Chihiro notices that it has a thorn in its side actually the handlebar from a bicycle, which leads to a lot of miscellaneous junk stuck in its body, the result of people throwing unwanted objects into the river. When she pulls the thorn and everything else along with it out, the stink spirit transforms into a much more benign river spirit.
- The folk tale The Lion and the Mouse. Mostly likely the Ur-Example of this trope.
- Kirikou and the Sorceress: The sorceress has a massive thorn in her back, stuck so deeply in the only way to remove it is with your teeth. When it's removed, she gets better.
- Inversion: In House of Frankenstein, removing the stake from the heart area of Dracula's skeleton lets him instantly re-form and go on a "rampage" of bloodsucking.
- The film Namu, The Killer Whale had one of these—Namu was provoked into a rage by someone throwing him a fish rigged with a hook. He finally calmed when someone found the hook and pulled it out.
- In Snow Dogs, the malamute Demon seems to have a permanently vicious temperament. Near the end of the film, we learn that it's all due to a bad tooth. Ted (a dentist) pulls out the tooth, and Demon gratefully licks his face.
- In the film Jungle Boy, main character Suresh figures out that a horse is rearing because of something stuck in its hoof.
- Riftwar Cycle: A bear went on a rampage because it had an arrowhead stuck in it. The arrowhead was shown be made oddly or wrong, and its maker—also assumed to be the one who shot it, ended up wanted for murder—specifically of those the bear had killed in its rampage.
- In The Silmarillion, Carcharoth was already evil and violent to begin with when he ate the hand of Beren, which caused him to go on a mindless rampage - probably because the hand in question was holding a silmaril at the time, meaning that Carcharoth's guts were engulfed in constant burning agony. Possibly one of the most extreme examples of this trope—both in terms of deadliness of rampage and the pain.
- In Dino Attack RPG, Rex's only tamed Mutant T-Rex, Maw, suddenly went on a maddened rampage and, in the process, nearly killed Dino Attack Team's founding members. When Rex was finally able to calm Maw down, he discovered that the T-Rex had been stabbed in the foot by Sam Sinister.
- In Warhammer 40,000, Angron and his World Eaters are the absolute incarnation of this trope. Hell, they got devices called Butcher's Nails in their heads that cause them to go batshit insane with anger. And you know what? We may never know, but Angron could have been the most brotherly primarch (read: Demi-God) if he didn't had that mind raping, eternally hurting device installed on his skull by Nucerian Slavers, based on his and the Twelfth Legion's past.
- Mass Effect: The rachni are wreaking havoc on the research station on Noveria. It turns out this is because they are separated from their mother, causing them to become mindless and violent. The original Rachni Wars were also a result of this: the rachni are normally a peaceful species, but the Reapers made a "sour, yellow note" that caused the rachni to viciously attack the salarians and asari.
- DuckTales Remastered: The Yeti boss of the Himalayas attacks Scrooge because of the Crown of Ghengis Khan stuck in her foot.
- Champions Online: The reason for the Qualar invasion in the tutorial; several devices in champion's headquarters are making a sound that is "driving the Qualar CRAZY!
- The Care Bears: Adventure in Wonderland had the Jabberwocky, who was in a state of crankiness, due to a thorn stuck in his paw. With the combined effort of everyone, the thorn was removed, inciting the Jabberwocky's Heel–Face Turn.
- An episode of Doug, with the eponymous character posing as his superhero persona Quailman, involved a giant monster created by Dr. Rubbersuit called Klotzilla that was rampaging throughout the city. Quailman then discovered that said monster had a thorn stuck in his foot and removes the thorn, helping Klotzilla from the pain he was in.
- In the second episode of My Little Pony: Friendship Is Magic, Fluttershy manages to calm down an angry manticore attacking the group, and learns that its fury was because of a thorn in its paw.
- In The Simpsons, a bear that assaulted Homer was aggressive because of some electronic chip attached to his ear.
- Ed, Edd n Eddy: In "Little Ed Blue", Ed becomes abnormally grump and bad-tempered, and goes on a rampage that genuinely scares the entire cast, all because he has a pebble in his shoe.
- Spongebob Squarepants: "The Smoking Peanut" has a giant clam behaving this way. Everyone thinks it's because it had a peanut thrown at it, but later it turns out its egg was stolen.
- There was also one episode in which Gary is entirely unruly and goes around biting people. It turns out it's from a splinter. A very, very large splinter. Large enough to almost make this example a parody.
- Dink, the Little Dinosaur: Dink and his friends had to convince a really huge dinosaur to help them in one episode. He initially refused, stating he had his own share of trouble, he had a thorn stuck on his foot.
- In Danny Phantom, this is how Danny meets Frostbite.
- In the ChalkZone episode "That Thing You Drew", the Yadda Yadda Yeti turns out to be good-natured and was only acting fierce because she had a pickle dog stuck between her toes and it was causing her pain.
- In an episode of The Powerpuff Girls, the giant flaming squirrel rampaging through Townsville turns out the be saying "Help! Put me out! I'm on fire!" in Spanish. Bubbles is able to translate thanks to her ability to speak Spanish. Blossom is able to put out the fire with her ice breath. The bulk of the episode is then dedicated to Buttercup trying to find her own special power.
- It was suspected that the rogue elephant of Aberdare Forest behaved the way it did because it had a bullet lodged near the nerve center of its tusk.
- The maneating leopard of Gummalapur had two porcupine quills stuck in one forefoot, making it unable to run after faster prey. Interestingly, the Androcles' Lion trope is also present in this story, but with a twist: the hunter assigned to kill the leopard, Kenneth Anderson, fed a hungry stray dog that later helped him locate the leopard. Anderson called the dog Nipper and adopted him.
- Heartwarming example with a tiger here
- Subverted in the case of the Maneaters of Tsavo: one of the lions had a broken jaw that had healed, probably due to being kicked by a zebra or wildebeest, so it was initially assumed that it had become a maneater due to being unable to hunt its normal prey. However, an analysis of the Tsavo attacks showed that the lions were primarily hunting humans only during the dry season when herd animals were scarce. During the rainy season when the herds returned, the lion attacks slacked off, indicating that they were in fact merely targeting the humans opportunistically.