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- In The Sandman, a former girl of John Constantine's swiped an artifact he had thinking it was drugs. It turns out to be Morpheus's Bag of Sand. This is a very bad thing, as it basically turns her life into a literal living nightmare.
- In Lucifer, demonic succubus Lady Lys gets a hold of Christopher Rudd, one of Hell's damned, as her personal plaything. Rudd, at first relieved he's being spared the suffering he's endured for centuries, comes to resent the situation, since he believes himself damned worse for consorting with demons than for paying penance. Lys, like many of Hell's denizens, is addicted to Pain(capital P), which is the distilled essence of the souls suffering in Hell. Rudd, however, distills ACTUAL Pain, pain as humans feel it, and gives it to Lys. When Lys imbibes it, she feels the actual pain of the souls she's tortured and played with, making her feel remorse and shame for her past actions. The experience turns her from a hedonistic slut into a broken, emotional wreck.
- One of the origins of the Sentry of Marvel Comics (He has a Multiple-Choice Past) is that he was a junkie who stole the Super Serum in hopes it would get him high. It turned out remarkably well for him...except for the side effects.
- Like The Sentry, but far less powerful, minor Spider-Man villain Freak started as a drug addict who consumed a mutagen thinking it was a new designer narcotic.
- There was running plotline in Brian Michael Bendis's Marvel stories about regular people taking MGH, a drug that grants super-powers along with a high.
- In Grant Morrison's X-Men run, a new power-enhancing stimulant called "Kick" starts taking the mutant community by storm. Turns out it's a mind-controlling, aerosol form of the malevolent, sentient bacteria Sublime, the ultimate villain of the story.
- A Spider-Man story had the Absorbing Man transforming himself into cocaine, then being cut up and sold to unsuspecting addicts who got their own superpowers.
- Wolverine once fought an Eldritch Abomination called Sporr, which had been blasted to molecules millennia before by the Celestials; it reemerged when someone deliberately overdosed on cocaine that was grown on the mountain where it "died" because said cocaine gave its users limited super-powers.
- Legion of Super-Heroes mainstay Bouncing Boy got his powers by mistaking an elasticity drug for a bottle of soda.
- The Suicide Squad once thwarted a scheme by voodoo-using New Orleans gangsters to distribute free heroin samples to addicts that would turn them into a literal zombie army.
- In Pulp Fiction, Mia Wallace finds what she thinks is cocaine is Vincent Vega's coat jacket, and snorts it up. It's in fact VERY pure heroin that Vincent bought earlier, and she ODs on the spot, only escaping death through Vincent's quick thinking and a well-timed adrenaline shot to the heart.
- In the horror film Leviathan (1989), the crew of the underwater mining facility find a sunken Russian ship and inside find what they think is vodka, which they gladly drink. It's actually a solution which has The Virus, mutating the crew into a hideous monstrosity.
- Return of the Living Dead: Rave to the Grave has kids in raves gulping down pills of what they think is a rave drug like Ecstasy, but it is actually Trioxin, the chemical phlebotinum from the movies that turns people into zombies.
- In Beyond Re-Animator, a junkie prisoner manages to get some syringes of Re-Agent, which he promptly shoots up. Hilarity Ensues.
- The Stephen King short story The Ten O'Clock People involves a relatively mild example: a certain level of nictotine and withdrawal symptoms found in smokers trying to quit— and only in smokers trying to quit — gives them the power to perceive that humans are being replaced by a race of disguised bat-like monsters.
- In another Stephen King story, "Gray Matter", an alcoholic slob drank a can of skunky beer and started turning into a flesh-eating fungus-like creature.
Live Action TV
- On Stargate Atlantis, Ford is injected with the enzyme Wraith use to strengthen humans so they can survive the feeding process, but doesn't get eaten afterwards. As a result, he gains super speed, strength, and stamina. The enzyme proves highly addictive, severely impairs judgment, and the withdrawal process is not pleasant. Ford ends up going rogue and gathering together a band of guys who use the enzyme to aid them in their fight against the Wraith.
- In the Millennium episode "Human Essence" Emma Hollis's junkie sister claims that a new strain of heroin is turning users into monsters. Frank and Emma gradually come to realize that she's right.
- Much of the action in Shadow Warrior 2 revolves around Shade, a drug distilled from Crude which comes from the Shadow Realm. Humans who use it for too long or who use too much of it end up turning into demons.
- Mass Effect has a Fantastic Drug where cocaine is exposed to Element Zero. The end result has not only the mind-altering effects of cocaine, but gives the user low-level biotic (telekenetic) abilities. Needless to say, someone who is coked up, able to TK small objects around the room, and hasn't the training to do it properly is a headache for the security forces.
- There's this episode of Code Lyoko called Temptation. Jeremie translates a part of Franz Hopper's diary, and uses the info to invent this weird headband. It's supposed to raise his intelligence every time he uses a Return to the Past (go with it). He first notices the side effects, like irritability and fainting spells. Then he realizes that all the calculations he made while using the headband were wrong, meaning it had no positive effects whatsoever (except to make him a temporary Memetic Badass).
- South Park: Cartman ingests Kenny's ashes, thinking it's chocolate milk mix. Now he has Kenny's soul trapped in his body.
- On The Tick, Dinosaur Neil, a paleontologist in a dinosaur costume, accidentally eats dinosaur genetic material thinking it was pasta salad, which turns him into a real dinosaur.
- Cats perceive antifreeze as sweet and tasty; it quickly kills them via liver damage in very low doses.
- Ethylene glycol, the main ingredient in some brands of antifreeze, also tastes sweet to humans and a number of other species and is no less poisonous than it is for cats. There have been cases of children, pets, livestock, and wild animals drinking antifreeze unwittingly, as well as it being used to deliberately poison people. To cut down on the accidental deaths and homicides, many manufacturers add a bittering agent to ethylene-glycol-based antifreeze, which eight US states require by law.
- In the early 20th century, radium was sold as a wonder drug because of its healthy glow. A business tycoon named Eben Byers who started obsessively chugging a radium serum eventually perished, leading to the squicky Wall Street Journal headline, "The Radium Water Worked Fine until His Jaw Came Off."
- Often happens with methanol. This substance looks like ethanol, smells like ethanol, tastes like ethanol and even produces buzz like ethanol. But if you're lucky, it'll burn your eyes from inside for good, and if you're unlucky, it'll kill you.
- Russians have devised a folk way to tell methanol from ethanol. You make a small spiral out of copper wire, heat it with a cigarette lighter and drench in the suspicious alcohol. If you smell "morgue" (formaldehyde gas, a very characteristic "stinging" smell), it's the deadly stuff.