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Anime And Manga
- Senki Zesshou Symphogear features ancient power armours that run on "phonic energy", also known as singing.
- The Legend of Black Heaven has an alien super-weapon being powered by Oji's epic rocking.
- The original version of Astro Boy's Artificial Sun, a giant, floating, octopus-like robot that generates massive amounts of heat, was controlled by playing a keyboard. To activate it you play "You are my sunshine, my only sunshine", naturally. Most subsequent adaptations leave this out for being rather silly.
- In the comic Grimjack in issue #76 he travels to a dimension where sound can be used as a weapon. He, an old friend, and a number of new allies fight to protect "The Heart of Rock" from the evil forces of corporate music. The weapons used are musical instruments. And most of the characters are based on rock musicians.
- Extremely important in Left Beyond for both timelines: in the Millennial Kingdom "wubbers", basically Weirding Module expies, are the setting's replacement for tazers and other nonlethal weapons, while in Tripocalypse it was a sonic weapon that brought the Battle of Armageddon to a halt.
- Popular Fanon has Vinyl Scratch build and use a "bass cannon", a huge set of speakers that fire a Wave Motion Gun-like beam of pure dubstep. It's apparently quite effective, as it was able to defeat Discord with one blast in "Epic Wub Time", a non-canon fan animation. Also, at the beginning of the video, Octavia explains how Vinyl cleans dishes "with wubs".
- Metal Effect, a crossover fic between Brütal Legend and Mass Effect replaces the Element Zero of the latter for the Heavy Metal Magic Music of the former, resulting in Magitek starships fuelled by The Power of Rock.
- Major Domo in Captain EO.
- Durand Durand's "Orgasmic Organ" in Barbarella.
- Willy Wonka has a door with a musical lock, opened by a piece by Rachmaninoff.
- Masters of the Universe has the Cosmic Key, a device that is capable to open portals the destination of which depends on the notes that are played on it.
- Prometheus has alien holographic displays which are somehow controlled through the playing of a flute.
Live Action Television
- The Star Trek: The Original Series episode "The Paradise Syndrome" features a potentally world-destroying asteroid held at bay by a repulsive field that is controlled through the use of music
- In Chrono Trigger, the cathedral of the Middle Ages features doors that can be opened by playing a nearby organ.
- In Mother 3, you can perform combo attacks by pressing the A button to the beat of the battle music. This feature is described in-game as a "sound battle".
- Final Fantasy X-2: Vegnagun's controls are a massive keyboard.
- King's Quest IV: The Perils Of Rosella: Rosella plays a certain tune on the haunted house's pipe organ to get the key to the burial vault.
- In Loom many actions, properties and abilities (to name a few: opening, night vision, invisibility, sharpness, green color) are reflected as sequences of notes ("drafts") on the magical distaff (hinted to be a Sufficiently Advanced Technology of 9th millennium). When spellweavers play the notes, they duplicate the effect. Oh, and playing a draft backwards gives the opposite effect. This gives the game its unique interface: to perform any action beyond simple goto/pick/examine the hero has to learn the correct draft from somewhere and play it.
- The Dubstep Gun from Saints Row IV plays music when fired, and causes enemies to dance uncontrollably until they keel over dead.
- Lucio from Overwatch.
- There's an episode of Batman: The Animated Series which involves playing the beginning of "Ode To Joy" to unlock the secret room.
- The girl's voice in Rock & Rule was significant to help Mok with his summoning spell.
- A Disney Silly Symphonies short "Music Land" involved a Romeo and Juliet-esque romance between the children of rival kingdoms of anthropomorphic musical instruments. This ends up sparking a war where the queen of the Symphony Islands and the king of the Isle of Jazz fire their music as weapons at each others' kingdoms.
- In the Spongebob Squarepants special "Atlantis Squarepantis", the fact that the Atlanteans have evolved beyond petroleum fuels and use song to power their vehicles instead kicks off the Excuse Plot for the musical.
- The lost city of Tinnabula from the two-part TaleSpin episode "For Whom the Bell Klangs".