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- The episode of Sabrina the Teenage Witch where her friend ends up in the Other Realm has the woman who reads out the laws of said realm blow on a bubble pipe when she's having her conversation with Sabrina.
- A much later episode had Sabrina and her friends involved in a Murder Mystery Weekend. Salem points out that the body is covered in pipe smoke. The only pipe smoker points out that Salem is smoking one as well, but Salem blows some bubbles out of his to prove his only blows bubbles.
- In one Cheers episode, Diane dreams that Sam reveals himself as debonair and sophisticated, including smoking a pipe. When she wakes up, she goes to where the pipe was and finds that it really exists. Then she blows into it, and bubbles come out.
- Wyatt Cenac busts one out when pontificating on the distinction between ascots and neckerchiefs on The Daily Show.
- Alfred Hitchcock is seen using one in the episode "The Perfect Crime" of Alfred Hitchcock Presents
- Mad Magazine once had a comic where where two boys are blowing bubble pipes. One is exhaling bubbles like an actual pipe, to which the other says "I don't think you're supposed to inhale these."
- Jason uses one in FoxTrot whenever he has delusions of being a millionaire and is trying to look sophisticated.
- In the Garfield comics, Jon uses a bubble pipe once or twice. Garfield himself once blew soap bubbles with a real pipe:
Jon: My ivory-stemmed, mother-of-pearl inlaid meerschaum!
Garfield: My blow toy.
- The Sims 1 had a bubble blower in the House Party expansion pack that was pretty much a bong in all but name and visible function.
- The Sims 2's University expansion introduced colorful bubble blowers that raised the Sims' fun meter at record speed, made them giggle a lot and eventually made them ''float in the air''.
- Quilt the necromatic golem uses one several times in Dominic Deegan.  Later actually used for something when he uses the bubbles as crystal balls as an alternative form of scrying, since crystal balls and other orthodox methods are being monitored.
- Final page of Masters of the Art, a recently ended webcomic.
- Girls with Slingshots: Jamie has one as part of her Holmes-inspired "Romance Detective" look.
- El Goonish Shive: Tedd has one in an early strip. True to the comic's style, the bubbles come to life and attack him.
- Jansen the art teacher has one in The Inexplicable Adventures of Bob!
- In The KA Mics Gertrude uses one while investigating a mystery.
- Sabrina Online: The Christmas 2013 strip features a bubble bong◊.
- In The Simpsons:
- Bart blows bubbles from his pipe when he falls in love with an older girl and ends up dressing like Hugh Hefner.
- Bart also uses a bubble pipe when visiting the real Hugh Hefner in "Krusty Gets Kancelled".
- Used once in Ed, Edd 'n' Eddy, when Nazz was babysitting at Eddy's house and he believed that it was a date.
- Yakko Warner of Animaniacs (Although he is drawn as a child, he was drawn around the 50s, technically making him at least in his 60s) once "puffed" on a soap-bubble pipe while parodying highbrow intellectuals.
- In a VeggieTales pastiche of Sherlock Holmes, the Sherlock character has a bubble pipe, and at one point he inhales by accident and chokes on the soap.
- Sokka in Avatar: The Last Airbender.
- Beezy on Jimmy Two-Shoes uses one on occassion.
- Snoopy dons one of these in a Peanuts special, It's a Mystery, Charlie Brown, where he's playing a detective trying to find Woodstock's nest. Complete with a Running Gag of where the one large bubble goes...
- Master Shake of Aqua Teen Hunger Force has one in the episode "Two and a Half Star Wars Out of Five" when he suspects that the Pink Man is a werewolf. He also adopts Sherlock Holmes-like speech.
He is a werewolf, Fryman. He saw Carl's full moon, and it changed him.
- The Powerpuff Girls make use of this in the body swap episode: The Professor, who is sometimes seen with a pipe, had swapped bodies with Buttercup. He's seen with it later as Buttercup, but it humorously turns out to be a bubble pipe instead.
- Spongebob Squarepants has used a bubble pipe in at least one episode. Not much of a surprise, considering how he blows bubbles in roughly 95% of the series, including entire episodes dedicated to them.
- True to the trope's description, Simon uses a bubble pipe (that he borrowed from Alvin) in the Sherlock Holmes episode of Alvin and the Chipmunks. He, naturally, plays Holmes.
- In My Little Pony: Friendship Is Magic, Pinkie Pie and later Twilight Sparkle sport one of these while dressed up like Sherlock Holmes in the episode "Mystery on the Friendship Express". One of the show's background characters, an elderly stallion named Mr. Waddle, has the image of a bubble pipe as his cutie mark, and another bubble pipe cutie mark is included in the Virtual Paper Doll Web Games The Fabulous PonyMaker and Rarity's Bridal Boutique. In a later episode, Discord bubbles a corn cob pipe.
- In Muppet Babies, Beaker doesn't just imitate Sherlock; he uses the bubbles as a weapon against an allergic opponent. (How he determined the allergy is hard to defend, but in a kiddie Imagine Spot it hardly matters.)
- In Storm Hawks, Stork has one, most notable in "Leviathan", but in typical Storm Hawks fashion, the prop shows up all the time when the crew is throwing things around.