Any time Ashley and Leon reunite in Resident Evil 4, especially when they hug after Ashley gets out of the prison area after dealing with two Zealots and the living suits of armor that try to kill her. Then you know it was worth going through hell without a weapon.
Also late in the game when Leon and Ashley use the removal machine to get rid of their plagas, Ashley hugs Leon again in relief.
Given that Sherry is quite the Woobie who tends to hug Claire a lot she can get a few 'Awww's' out of the player.
The fact that Claire broke into an Umbrella base to find her brother, and then continued to search for him even after being captured in Code Veronica. And the fact that the moment he heard she was in danger Chris instantly sprung into action, climbed up the rock face of the island and then flew a plane to Antartica to find Claire in return.
