Colin as Serena's voice: "...let's see what you got, little man!" Wayne: (Death Glare at Colin)
Even before that:
Colin as Serena: "Let me start by saying three things. First of all, I'm a princess. (Serena hams along) Secondly, if you start yelling at me, I will cry. (Serena goes predictably sad.) Thirdly, if you keep yelling at me I will kill you."
The Jack and Kelly Osbourne episode. Two guests at once has the bonus of their own interactions adding to the humor. Of special note, the "First Date"-inspired game only has one bell and horn this time, leading to Kelly snatching them from Jack to state her point of view, so to speak.
The whole Ricky Gervais episode, especially since you really don't expect Ricky to become the Butt Monkey right off the bat.
