- From "Peek-a-Boo Camera":
Fred: If our wives see that film, we're dead!Barney: Worse, Betty will kill me!
- The second credits sequence (which is considered more popular than the first one due to Memetic Mutation). At the end, Fred would put out the cat, which would jump back in through the window and toss Fred out. Fred is forced to bang on the door and shout for "WIIILLLMAAAA!!"
- The "Happy Anniversary" scene near the end of the episode "The Hot Piano", where Barney and a group of policemen (It Makes Sense in Context) constantly interrupt Fred with their singing as he tries to give Wilma best wishes on their wedding anniversary, much to Fred's increasing frustration.
- An episode had Fred and Barney assisting what turned out to be a female spy. She asks if they're married, and Barney replies "Nope... we're just good friends."
- Fred is presented with his godchildren, who he says are all named "Fred." Wilma asks if that would get confusing. Fred says, "Not really, seeing as they're all girls."
- In an episode where Stony Curtis comes to the house, Wilma has Betty pretend to be her "upstairs maid".
Fred: We don't have an upstairs maid! WE DON'T EVEN HAVE AN UPSTAIRS!
- In "Son of Rockzilla", Fred (stuck in the namesake monster costume) is been chased by Doris the Finkasaurus (resembling the movie monster) that escaped from the zoo, and then the police. The three run over Barney, who came back with pliers to get Fred's costume off.
Barney: Just for that: I won't help you take off your phony head!
- "The Long, Long Weekend": A female hotel guest is terrified by the sight of Fred and Barney crashing into her room, and calls the manager. The hotel manager picks up the phone.
Manager: Front desk.Woman: AAAAAAH!!! (unintelligible sobbing)Manager: ...Would you repeat that, madam?Woman: AAAAAAH!!!Manager: No! Not that part!Woman: Oh. (unintelligible sobbing)
- Fred feigning an ailment in "The Flintstone Flyer" as the two couples are about to go to an opera. Both the English and Spanish dubs of said scene.
- "Wilma Flintsone, a natural redhead?"
- The "Dr. Sinister" episode has some great running gags.
- The guys constantly attempting to explain they're not spies. "We were on our way to get brontosarus burgers..." "And some buns..."
- "Oh, no, Madam Yes!"
- Madam Yes exiting the scene calling for Fred and Barney "don't tell them anything." "But we don't know anything!"
- When they find themselves locked in a room with Madam Yes, Barney starts pounding on the door and begs Dr. Sinister to save them.
- The ending as Fred and Barney find Madam Yes showing up at the door and immediately slam it and start nailing boards over it.
- Fred going on a rampage in at Mother's place when he sees Wilma on TV doing her cooking show, while he's stuck chewing on a steak sandwich that resembles the bottom of a shoe. Specifically it's a diner run by a man named Sam Mother. Also, the one-sided conversation Barney has with Fred when he calls from jail that makes it sound like he hit his mother and smashed her television.
Barney: Yeah Oh hiya Fred. What's new? What are you doing in jail Fred? You broke up a television set? In Mother's Place? And hit Mother? Oh Okay Fred. I have to go down and bail Fred out Betty.Betty: Why you ought to leave him there, Anyone that would strike his mother and break her tv set should be in jail. Those old folks love tv.Barney:Not Fred's Mother, Sam Mother.Betty: I don't care whose mother it is, it just isn't nice.Barney: But he runs a beanery, you know a restaurant.Betty: It makes no difference what he does, we're concerned with his mother.Barney: But But But Sam Mother who owns it, Ohhh Skip it. I'll explain later.
- Fred going on a diet as part of a game show challenge, where he has to drop 40 pounds, and his increasing desperation for food, including attempting to steal a bone from Dino.
- The feud between Fred and Barney when Barney confiscates Freds bowling trophy due to his refusal to pay his membership fee for the gentlemens club they're part of. It quickly devolves into a turf war, with Barney sneaking into Freds yard to take back the various things Fred has borrowed over the years, and then running like hell back to his own yard when Fred catches him.
- In the episode where Fred switches places with a look-a-like King of Stonesylvania, we see multiple times knives being thrown at him from off screen. He jokes that he is thankful there is not one good knife thrower in the entire kingdom.
- This line in The New Fred and Barney Show episode, "Haunted Inheritance".
Fred: (excited) LIABILITIES!
- The can opening bird saying "This job sucks!" after opening a coke bottle.
- It's especially amusing when you bear in mind that the original show's many animal-based "machines" had a penchant for breaking the 4th wall, shrugging at the viewer and justifying their occupation by saying "It's a living". So having one give his full negative opinion on his job (and the fact that slang like that wasn't appropriate or around in the 1960s) is a bit of a humorous switch.
- This exchange:
Sharon Stone: Can I get you anything? Coffee?Fred: Sure.Sharon Stone: How would you like it?Fred: ..In a cup?Sharon Stone: Bold choice, Mr. Flintstone!
- The families came home to see Dino and Wilma's mom tied up. Fred immediately went to untie Dino, with Wilma's mom growling in anger.
- Fred tries to think of a way to stop the machine, and he suddenly thought of Wilma's mom getting eaten by a dinosaur.
- The Bad Bad Acting in the TV movie about Fred as the embezzling executive.
"Sharon Stone": Mr. Flintstone! What are you doing?!"Fred": I'm an executive! I'm... EMBEZZLING!"Sharon Stone": I am shocked!