In the Captain SNES: The Game Masta Chrono Trigger Rip Off crossover, Captain SNES taking out Lavos Magus with SNES's Fruit Pies laced with Chocopectate
Round 8 of the Date Captain SNES contest. Luigi activates Negative Zone at the same time that Alanis Morisette activates her Power of Irony. This breaks reality. We don't get to see all of what ensues, but a philosophical President Tyrannosaurus is involved.
PRETTY RAINBOW APOCALYPSE COMBO!
Mario's refusal to help Megaman against a giant radioactive Q-bert rampaging through Nexus because Megaman's "tried everything he could think of" didn't involve jumping on his head. Mario knows how this works.
That is, in fact, exactly how the giant radioactive Q-bert is eventually defeated. Always listen to Mr. Red 'Stache.
And not only do the guards buy his alibi (traveling through time and fighting the LLL-er, KKK), they ask him for an autograph, warn him not to see My American Cousin and he fools the Brain Lord, aka "The smartest person in all of Videoland".
Turns out everyone's obliviousness is justified, as Hippo is using an ancient technique taught by great masters. The name of the technique? NihtRepap.
Samus implanted a behavior modifying chip in Eggplant Wizard which prevents him from acting against her or making puns by shocking him when he tries. However, she also put a safety feature in which shocks him into unconsciousness when she says two words. Two words she specifically chose because nobody would ever say them together accidentally. Sweet Christmas.
When Alex is faced with his cynicism - a naked Alanis Morissette covered with a censor bar - he remembers that he had a crush on her... until he saw a video where she was naked, and realizes her ultimate attack must be taking her censor bar off. He promptly surrenders.