In the church where Father Martin is about to have himself immolated, he declares it to be your "Penultimate Act of Witness." (Penultimate means "second to the last.") At first you think he's just misusing the term, but in fact he's foreshadowing the fact that he rigged the elevator to take you to the scientific facility where the Morphogenic Engine and Billy Hope are located. Seeing them will be your final act of witness (if you survive.)
A document you find in the Whistleblower DLC shows that Jeremy Blair and Rick Trager used to play golf together, which means that Miles was right on the money when he snarkily described Trager as a douchebag that "probably has a set of golf clubs in the trunk of his Audi."
Pointed out in the Two Saiyans Play Let's Plays, Miles has no gun or taser to protect himself from the patients. He doesn't even have backup. Or a flashlight. Granted, all the e-mail from Waylon said was that there were some twisted and illegal experiments happening at the facility, so he wouldn't have much of a reason to think that he would need to protect himself from bloodthirsty patients at every turn.
There's a women's ward and reports to be found on female patients, but... where are the women? A document found in Whistleblower reveals that the Walrider began targeting them specifically when it first went rogue, and the vast majority of them were moved to another facility. Another document mentions that Murkoff had to fire all the female staff because exposure to the Morphogenic Engine was causing them to have phantom pregnancies.
The reason Miles and Waylon are called "heavy" by Trager and Gluskin respectively is because they are likely the only well-fed people in the entire asylum.
While relatively few patients in the game are violent, given the large number the player encounters, even fewer attack Waylon in the Whistleblower DLC. Perhaps the reason is that Miles is obviously an outsider based on his clothes, and therefore perceived as a threat. Waylon, on the other hand, looks like any other inmate.
In Whistleblower, Trager's corpse is found fairly close by to where Eddie hangs his victims. This means that if, in the original games, Miles had went in another direction after killing Trager, he could have easily ran into Eddie.
Waylon is forcibly committed at the beginning of Whistleblower for his... well, whistleblowing. But he wonders how many others in Mount Massive suffered the same fate. According to this document from the first game, at least one orderly could have been.
An unsettling idea can be the fact that most of the patients you encounter are relatively harmless (or at least can't kill you easily) and the majority appear catatonic, scared, and traumatized after being subjected to the experimentation. While Mount Massive defines itself as being for the Criminally Insane, it's entirely possible that most of the men we see are not actually deranged psychopaths by nature but genuinely unwell individuals who have committed crimes because of their different mental illnesses, and some may very well have been capable of full rehabilitation and recovery if only they were in a better facility. Most of them are probably just as scared as the player, but are too traumatized and lack the lucidity needed to escape, and the horror of the Walrider experiments makes any recovery for these guys nearly impossible.
When you find out about Eddie's horrible past, wherein he was repeatedly and brutally sexually abused by his father and uncle as a child, it makes the scene where you first see him gut-wrenching in retrospect. The orderlies, two large men, are dragging him into the Engine kicking and screaming, they've stripped him down to his underwear, and what is he doing? Desperately pleading for help and screaming that they're going to rape him.
document from the first game, at least one orderly could have been.