Her preference for people who "look like Mick Jagger" is already pretty creepy... Then you see that her MySpace page says that "Mick Jagger might be my dad, fo realz..." Wait, what?
She also likes beards... now put them together....
You know all that pastel dust that sprays everywhere in the "Take It Off" video? It used to be people.
Listen to the lyrics of most of the songs on Animal. They're really depressing. Even most of the ones that aren't flat out "I've been totally abandoned and have no friends and everything just fell apart" are at best "Screw it I just don't care anymore".
Similarly, "Dancing With Tears In My Eyes" which is exactly what it says on the tin, namely a girl whose intentionally destroyed her relationship and is "Dancing with tears in her eyes just fighting to get through the night."
Harold Song is yet another example of this. "They say that true love hurts; well this could almost kill me. Young love murdered; that is what this must be. I would give it all to not be sleeping alone. The life is fading from me while you watch my heart beat."
In the same vein, Crazy Kids can easily be interpreted as a deconstruction of her personality. While the lyrics at first seem like her usual song type, the tone and the wording seem to imply that it's about her being tired and exhausted of her routine.
The video for Take It Off by Ke$ha involves partying youths jumping into each other to explode into dry powder paint. Later on, the remaining partygoers have a powder-paint fight in a drained swimming pool, throwing handfuls of the stuff at each other. Which is all very fun... until you realise there was no paint in the scene at the beginning of the video, so they are in fact throwing corpses at each other...
There are Unfortunate Implications in We R Who We R which was (allegedly) made in response to several gay teen suicides including some that involved jumping off of buildings. In the music video, Ke$ha herself jumps off a building and falls several stories.
In her defense, she does get caught and winds up crowd surfing but that might just make some people even more uncomfortable as it might be seen as telling those teens that if they jump off of a building they'll wind up in a never ending party.
Or that a bunch of people coming together to save someone can prevent the damage.