Drinking game for Yu-Gi-Oh!:
For all series in the franchise:
Take a sip every time someone says the word "card". Do this only if someone's nearby to call 911 for you.
Take a shot every time an opponent's "lockdown" could be stopped with a card like Dust Tornado or Smashing Ground. Guzzle if the player you're rooting for actually has a card that can stop it in their deck.
Take a drink whenever someone takes a children's card game... ahem, Duel Monsterstoo seriously. It is recommended this rule be disregarded during 5Ds, as alcohol poisoning can occur within the first episode.
Take a small sip of non-alcoholic beer every time someone reveals the effect of a face-up card to surprise someone else. Don't push yourself, you'll need a new liver anyway.
Take a sip every time the plot stops so that the power of the card can be explained.
Take a sip every time someone says "OH NO!" but only if you're not particularly fond of your liver.
Take a glass for every time a main character summons their signature monster during a duel. Take two glasses for every duel where a main character's signature monster DOESN'T play a role. Chug if a main character's signature monster does get used, but it's by somebody else.
Take a drink every time violence is clearly and poorly cut out in the dub. Finish your drink if they DON'T remove it.
Take a shot for every Never Say "Die" moment in the English version of any of the Yu-Gi-Oh! shows. (WARNING: Doing this while watching the original series' Battle City arc or the 5Ds Dark Signer arc will result in exploding livers.)
Drink half a bottle any time card games being Serious Business gets subverted. The early adventures in the manga do not count. (Don't worry; since these moments are so few and far apart, your liver won't explode. We hope.)
Take a drink every time someone is going to bet everything 'on this one card!' right before drawing it.
Take a drink when a protagonist wins a duel with less than 500 Life Points. Take two when they win with exactly 100 Life Points. Take three when they win with LESS than 100 Life Points left (Warning: GX is particularly fond of this one). Drink half a bottle if they win with Life Points that aren't a multiple of 100.
Finish the bottle if a protagonist loses (but only a shot if it's Yuma).
Take a drink whenever a duelist uses a card that has never been seen before, used by them before or has never been seen in that anime, to win a duel. Down the bottle if the card is never seen again.
Take a sip whenever someone loses their soul. For the purposes of keeping people alive during this drinking game, the souls in the Doma arc in Duel Monsters and Dark Signers arc in 5D's should count only as one for each time it occurs, rather than one-per-soul.
Take a sip every time there is Ho Yay. Take three gulps for every instance of Les Yay.
Whenever someone explains the effect of Pot of Greed, you are allowed to take two shots from your deck, er, drink.
Take one shot whenever any effect is activated which lets you draw two cards other than Pot of Greed. (Trust us. That is a lot.)
Take a shot every time a villain's gloating is interrupted.
Take a shot any time someone says "Not so fast!" or a variation thereof.
Take a shot whenever a character summons, sets, or activates a card the moment he or she draws it.
Take a shot every time someone draws or sets a card in the most dramatic fashion possible.
Take a drink whenever Screw the Rules, I Have Plot! is in full effect. (Warning; it's not recommended to do this with the second series anime, especially the Duelist Kingdom arc, unless you really hate your liver.)
Take a shot when an ATK of five or more digits is shown on screen. (Warning: ZEXAL II will not be kind.)
Take a shot whenever a character refers to the card they're about to play with some unnecessary adjective like "dreaded" or "mighty."
Take a second shot if they refer to it using some variation of "unstoppable" or "almighty."
Take another shot if this "undefeatable" card isn't really that incredible.
Take a shot every time someone calls out their monster's attack name. (The wiki has a list for reference.)
Take a very small sip every time the characters play games other than Duel Monsters. Good luck.
Take a sip every time someone says the word "game". Do this only if someone's nearby to call 911 for you.
Take a small sip every time a game is a Absurdly High-Stakes Game. Be careful. Take a shot every time a character actually dies from Penalty Games. Not required if the victim's fate is ambiguous.
Take a shot every time someone says they will never forgive someone. Two if its someone other than Dark Yugi. Three if it's the second time the character has said it to the same person. Finish your drink when they end up forgiving that person anyway.
Take a drink every time they mention getting a burger in early chapters!
Take a shot whenever Jonouchi or Honda beat someone up.
Take a sip for every scene Ryou Bakura appears where he is removed in the anime. Take another sip every time he or his alter-ego mentions Tabletop Roleplaying Games.
Take a small sip every time someone rolls a Super Critical during the Monster World RPG. Take a shot every time they roll a fumble.
Take a drink every time a card's effects are different from the anime or the real card game. Be careful during the early arcs and Duelist Kingdom.
DDD arc only: Take a drink every time Otogi's dad talks about getting revenge on Yugi's grandfather.
Millennium World only: Take a drink every time Bakura tells someone to die.
Take a small sip every time a plot point presented in any of the anime adaptations makes more sense in the manga.
Take a sip each time someone doesn't notice that Yugi is taller than before.
Take a sip every time someone mentions friendship. Chug if it's someone other than Anzu/Tea.
Take a shot every time someone mentions the heart of the cards. Two if it's not Yugi/Yami.
Take a drink any time when Mokuba gets kidnapped. Down it if he's wearing girls' clothes.
Take a drink any time Otogi/Duke accuses Yugi of cheating when he beat Pegasus and/or if he boasts that Yugi would have to retire if he wins. The more annoyed you are by what Duke says, the more you drink. You will be hammered pretty quickly.
Drink every time you see Jonouchi/Joey in a dog suit getting humiliated by Otogi/Duke's cheerleaders.
Take a drink any time that Marik says/thinks "Those fools" and proceeds to repeat his plan once again.
Once Yami Marik makes his appearance, take a shot each time he laughs. Also, say goodbye to your liver. You can also do the same with Yami Bakura.
Take half a glass any time Kaiba does an Evil Laugh. (Any more than that will rupture your liver or your bladder.)
Take a shot every time Pegasus calls a character "(name)-boy" or anything similar. For the Japanese version, take a shot every time he says "desu."
Dub-only, take a shot whenever Joey's confidence or Kaiba's ego gets in the way of their judgment.
Take a shot every time Yami says "The fate of the world depends on it."
When watching the Japanese version, take a sip whenever Shizuka says 'onii-chan' or Mokuba says 'nii-sama'. Tread very carefully during Battle City.
Take a drink every time someone uses an anime-only card. (If this is done post-Virtual World, have 911 on speed dial. With the recent strides Konami has been taking to release anime cards (especially the DOMA cards), this has been made slightly less risky. Just slightly.)
Take a drink every time Yugi draws exactly the card he needs for his strategy to work. Actually, don't; you'll die.
Take a shot every time a flashback shows previous events from the show. Two shots if it's a flashback you've already seen. After Yugi's first duel with Raphael, prepare to have your liver destroyed for the rest of the Doma arc.
During the Doma arc, take a drink every time someone's afraid to lose while the Seal of Orichalcos isn't actually in play.
For the Japanese version, take a sip whenever Yami says 'aibou'. Guzzle if he shouts it.
One shot whenever Seto Kaiba gets angry and doesn't listen to anyone. Be careful, though, you don't want any ill effects.
When someone starts to become redundant while explaining something about a card's effect/the plot (Dub only), take a sip.
Also Dub-only, take a sip each time the Shadow Realm is mentioned.
Every time someone says the word "destiny", take a sip.
Here are some more phrases you could play the drinking game with while watching the show.
Take a shot every time Yugi transforms into Yami, and another when Yami transforms back.
Take two shots every time Yugi duels as himself and not Yami.
Take a shot every time Pegasus sips his wine. Don't drink if he has the wine but doesn't drink it.
Take a shot every time that someone says the word "kizuna" (bonds). Two if it's not Yusei.
Alternatively, in the later arcs, take a shot whenever anyone says the word "kibou" (hope).
Or take a shot every time someone says "zetsubou", despair. Two if it isn't Aporia. Say goodbye to your liver.
Take a drink and run into the nearest wall every time someone's motorcycle crashes because of a duel. Avoiding the WRGP arc is advised.
Watch the dubbed version of Yusei and Kiryu/Kalin's duel in episodes 33-35, then take a drink for each time Kalin says something about "sending [Yusei] to the Netherworld!" or the "power of the shadows". Better line up a liver transplant in advance.
Take a drink every time Yusei says "Is that so?" right before turning a duel around.
In the Japanese version, take a drink every time Kiryu says either "Satisfy" or "Satisfaction".
Also, take a sip every time someone says "RIDING DUEL, ACCELERATION". Warning: the chances of surviving this is very slim.
Take a sip for every time a Synchro Chant is said. Take two if it isn't a member of Team 5Ds.
Finish your drink if the monster summoned conveniently does not have a summon chant.
Alternatively, finish the drink if they alter it from the previous time it was said. (We're looking at YOU, Turbo Warrior.)
Take one glass every time a Riding Duel takes place outside a proper arena.
Take two more if the place is conveniently unoccupied. Mix your cup with Vodka if no persons are seen during the duel, aside from people on motorcycles.
Take a drink every time Jack says something about being a King. (Definitely not advised during the Fortune Cup.)
To raise the stakes, take a drink anytime the word "King" and Jack Atlas are involved in the same character's dialogue. Your liver has no chance to survive make its time.
Take a drink for every speed pun in the English dub.
Take a drink every time, in the English dub, a background character voiced by Sean Schemmel can be heard. Take two if a major/reoccuring character voiced by Sean Schemmel shows up. And down the bottle if Sean Schemmel begins holding a conversation with Sean Schemmel.
Finish the bottle if Masaaki Endoh starts singing.
In episodes 47 through 49, take a sip every time III does something to cross the Moral Event Horizon even further.
Take a shot whenever Yuma duels against an opponent who DOESN'T have a numbers card. Take two if Astral and/or Yuma thinks that do, but they don't.
Take a shot whenever Shark tells Yuma not to get involved with him anymore.
Take a shot whenever Say My Name is invoked. Two if it isn't Kaito screaming "HARUTOOOOOOOOOOOOOOOOOOOOO!", Yuma screaming "ASTRAAAAAAAAAAAAL!", Kotori screaming "YUMAAAAAAAAAAAAA!" or Shark screaming "RIOOOOOOOOOOOOOO!"
Take a shot whenever Kaito summmons Galaxy-Eyes Photon Dragon using Photon Thrasher and Photon Crusher. Take two if he doesn't.
If you are feeling suicidal take a shot everytime Astral tells Yuma what to do in a duel.
If you're feeling really suicidal, take a shot whenever Yuma mentions "feeling the flow" (dub only).
Take a drink every time a Number is displayed on screen. (Not the one on the monster.)
Just because of episode 62, we're going to scale it up to taking two if it's not Hope, Shark Drake or their Chaos Xyz counterparts.
Take a shot each time Tron mentions something about his revenge. (You'll be dead long before you get to the finals of the WDC.)
Take a small sip every time dark aura can be seen around someone possessed by a Number or Barian's Force.
Take a drink anytime Yuma's Life Points drop below 1000.
Take a shot whenever someone Xyz Summons during their first turn. Take two if they don't.
Take an additional shot if they Xyz summon on their first turn, and then it cuts to whoever they are dueling against or is watching being surprised that they did so.
Take a shot whenever someone wins using a very situational card for a very unlikely situation. Nice knowing you.
Take a drink every time someone ends up in the hospital. Two if it ISN'T Shark or Rio.
Raid the liquor cabinet if you had the privilege of witnessing a legitimate No Turn Kill.note In the case of the "Exodia NTK", for it to qualify as legitimate, it's a good idea to have the opponent shuffle the deck thoroughly before the duel begins, so that there's no sleight-of-hand going on. The odds of that happening, assuming the player runs a 40-card deck, are 1 in 658,008. Nice knowing you.
Take a shot any time three copies of the same card exist on the field. Tokens are exempt from this.
Now for some deck-specific games:
Playing Nekroz, take a shot every time you search from your deck.
Playing Gusto, take a shot every time your opponent attacks a face-down floater.
Playing Inzektor or Dragunity, take a shot every time a equipped monster leaves the Equip spell position (either by going to graveyard or by being summoned to the field).
Playing Noble Knight, take a shot every time a Equip Spell is re-equipped by its own effect.
Playing Qliphort, take a shot every time your opponent surrenders because you summoned Apoqliphort Towers.
Playing Gladiator Beast, take a shot every time you tag-out (i.e. switch your on-field GB with another on your deck).
Playing Gravekeepers, take a shot for every card your opponent can't play thanks to Necrovalley.
You can do the same thing with any deck that runs Skill Drain or Vanity's Emptiness.
Playing Counter Fairies, take a shot every time your opponent goes Oh Crap! thanks to a Van'Dalgyon summon.
Playing ANY Dark deck, take a shot when you summon Dark Armed Dragon. Two if your opponent kicks it out of the field immediately.
Playing Monarchs, take a shot for every Caius or Raiza you summon. (Their Mega forms can count also)
Playing Synchron, take a shot every time you summon Shooting Quasar Dragon.
Playing Kaijus, take a shot every time you Special Summon a monster to your opponents side of the field by tributing one of their monsters.
Take two if you regain control of that monster afterwards.
Take a drink every time you encounter a Qilphort deck on an online Yu-Gi-Oh game or dueling simulator like Dueling Network or Yi-Gi-Oh PRO. Take two if it's clear the person using it has no idea what they're doing. * Doing this around the time this example was added (3/18/15) is not recommended.
Take a frustration shot if your opponent:
Absorbs your boss monster with Number 101 or shuffles it into the deck with Castel.