Drinking game for Yu-Gi-Oh!:
For all series in the franchise:
Take a shot every time an opponent's "lockdown" could be stopped with a card like Dust Tornado or Smashing Ground. Guzzle if the player you're rooting for actually has a card that can stop it in their deck.
Someone starts to become redundant while explaining something about a card's effect/the plot (Dub only), take a sip.
Take a drink whenever someone takes a children's card game... ahem, Duel Monsterstoo seriously.
It is recommended this rule be disregarded during 5Ds, as alcohol poisoning can occur within the first episode.
Take a sip every time the plot stops so that the power of the card can be explained.
Take a sip every time someone says the word "card". Do this only if someone's nearby to call 911 for you.
What about this: Every time someone says the word "destiny". Or any time the Shadow Realm is mentioned.
Take a sip every time someone says OH! NO! But only if you're not particularly fond of your liver.
Take a sip every time someone mentions friendship. Chug if it's someone other than Anzu/Tea.
Take a shot every time someone mentions the heart of the cards. Two if it's not Yugi/Yami.
Take a shot every time someone in the manga says they will never forgive someone. Two if its someone other than Yami Yugi. Three if its the second time the character has said it to the same person. Finish your drink when they end up forgiving that person anyway.
Take a glass for every time a main character summons their signature monster during a duel.
Take two glasses for every duel where a main character's signature monster DOESN'T play a role.
Chug if a main character's signature monster does get used, but it's by somebody else.
Take a drink every time violence is clearly and poorly cut out in the dub.
Finish your drink if they DON'T remove it.
Take a shot for every Never Say "Die" moment in the English version of any of the Yu-Gi-Oh! shows. (WARNING: Doing this while watching the original series' Battle City arc or the 5Ds Dark Signer arc will result in exploding livers.)
Drink half a bottle any time card games being Serious Business gets subverted. The early adventures in the manga do not count. (Don't worry; since these moments are so few and far apart, your liver won't explode. We hope.)
Take a drink every time someone is going to bet everything 'on this one card!' right before drawing it.
Take a drink when a protagonist wins a duel with less than 500 Life Points.
Take two when they win with exactly 100 Life Points.
Take three when they win with LESS than 100 Life Points left. Warning: GX is particularly fond of this one.
Drink half a bottle if they win with Life Points that aren't a multiple of 100, not counting when the above applies.
Finish the bottle if a protagonist loses (but only a shot if it's Yuma).
Take a drink whenever a duelist uses a card that has never been seen before, used by them before or has never been seen in that anime, to win a duel.
Take a sip whenever someone loses their soul. (For the purposes of keeping people alive during this drinking game, the souls of those used to fuel the Jikabushin/Earthbound Gods/Earthbound Immortals in 5Ds should count only as one for each time it occurs, rather than one-per-soul.
Take a sip each time someone doesn't notice that Yugi is taller than before.
Take a drink any time when Mokuba gets Kidnapped.
Down it if he's wearing girls' clothes
Take a drink any time Duke accuses Yugi of cheating when he beat Pegasus and/or if he boasts that Yugi would have to retire if he wins. The more annoyed you are by what Duke says, the more you drink. You will be hammered pretty quickly.
Alternatively, or additionally, drink every time you see Joey in a dog suit getting humiliated by Duke's cheerleaders.
Take a drink any time that Marik says/thinks "Those fools" and proceeds to repeat his plan once again.
Once Yami Marik makes his appearance, take a shot each time he laughs. Also, say goodbye to your liver.
You can also do the same with Yami Bakura.
Take a drink every time they mention getting a burger in the early manga!
Take half a glass any time Kaiba does an Evil Laugh. (Any more than that will rupture your liver or your bladder.)
Take a shot every time Pegasus calls a character "(name)-boy" or anything similar.
Dub-only, take a shot whenever Joey's confidence or Kaiba's ego gets in the way of their judgment.
Take a drink every time Pot of Greed is explained.
Take a shot every time Yami says "The fate of the world depends on it"
Millennium World Manga only: take a drink every time Bakura tells someone to die
Take a drink every time someone uses an anime-only card. (If this is done post-Virtual World, have 911 on speed dial.)
Take a drink every time Yugi draws exactly the card he needs for his strategy to work. Actually, don't, you'll die.
Here  are some more phrases you could play the drinking game with while watching the show.
Take a shot every time a flashback shows previous events from the show.
Two shots if it's a flashback you've already seen. After Yugi's first duel with Raphael, prepare to have your liver destroyed for the rest of the Doma arc.
During the Doma arc, take a drink every time someone's afraid to lose while the Seal of Orichalcos isn't actually in play.
Take a shot every time that someone says the word "kizuna" (bonds). Two if it's not Yusei.
Alternatively, in the later arcs, take a shot whenever anyone says the word "kibou" (hope).
Or take a shot every time someone says "zetsubou", despair. Two if it isn't Aporia. Say goodbye to your liver.
Take a drink and run into the nearest wall every time someone's motorcycle crashes because of a duel. Avoiding the WRGP arc is advised.
Watch the dubbed version of Yusei and Kiryu/Kalin's duel in episodes 33-35, then take a drink for each time Kalin says something about "sending [Yusei] to the Netherworld!" or the "power of the shadows". Better line up a liver transplant in advance.
Take a drink every time Yusei says "Is that so?" right before turning a duel around.
In the Japanese version, take a drink every time Kiryu says either "Satisfy" or "Satisfaction".
Also, take a sip every time someone says "RIDING DUEL, ACCELERATION". Warning: the chances of surviving this is very slim.
Take a sip for every time a Synchro Chant is said. Take two if it isn't a member of Team 5Ds.
Finish your drink if the monster summoned conveniently does not have a summon chant.
Alternatively, finish the drink if they alter it from the previous time it was said. (We're looking at YOU, Turbo Warrior.)
Take one glass everytime a Riding Duel takes place outside a proper arena.
Take two more if the place is conveniently unnocupied. Mix your cup with Vodka if no persons are seen during the duel, aside from people on motorcycles.
Take a drink every time Jack says something about being a King. (Definitely not advised during the Fortune Cup.)