A good chunk of Dubious Company's Cast can fit in here, but special nods go to Walter (one of the leads) who is a pirate, who can fly, and his flying pirate ships is powered by the crew's alcoholic signature. Captain Barry also counts, except he hasn't appeared for a while and never allied with them.
In Impure Blood, Elnor is another female example, fond of drink and fights and guys.
A female example, Pella from Looking for Group is introduced standing behind a door as a main character smashes it into pieces. She has barely said hello before punctuating a joke by cutting off another character's hand, which he finds as amusing as her. More than anyone else, she always faces battle with a smile on her face and a song on her lips. Never an appropriate song. At the current stage of the comic she has yet to find a problem she can't solve with sufficient violence. In quiet times she likes to use Richard as target practice.
And in a tribute to Baldur's Gate, his conscience is a hamster named "Boo". Boo tries to give him good advice, but Largo mostly misinterprets it.
Rumisiel from Misfile is a likeable drunken goof who got kicked out of Heaven for smoking pot while on duty and now spends most of his time sleeping on Ash's couch and trying to rack up karma points to get back in. Despite his usual drunken apathetic state, when he gives out advice on relationships he tends to be right and has displayed at least above average intelligence when circumstances have called for it.
Yeagar from Nodwick likes to think he's his group's resident Boisterous Bruiser. And to be fair, he is probably rather fun to get along with... unless you happen tobeahenchman.