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I was a little kid when I was watching this with my family, but I remember quite a few elements. The basic plot was that the main character's sister is somehow famous. For whatever reason the main character had to start dressing as his sister and pretending that he's her. Over the course of the show the character is fooling everybody, but the "bad guys" get a plan to foil him. They try to give him hormones or some such, but they end up giving them to the character's sister instead. The last episode ended with the sister's husband taking the sister to the main character's house and we see that the sister has become a man. The main character laughs and that's how the show ends.
Not sure if the show was even American. Could have been either Italian or Latino.