YMMV / The Incrementreeverse

• That One Level:
  • Getting your first Origin Point and having to make your way back to the second is by far the most painful prestige in the game, as it doesn't grant too many bonuses to return you back up to Origins. This means you'll have to go through most of the below prestiges nearly unaided by Origin's milestones/point gains, causing it to be agonizingly long. The only two layers that are made slightly easier (Neutrinos and Bosons) are extremely tedious to begin with, to the point that you'd be forgiven for not noticing the difference on a second playthrough of them after an Origins reset. The final prestige (Capsule) is actually far easier to get back up to despite having to do everything (including Origins) all over again, because Capsule's first milestone's exponentiation of all exponents by ^1.01 per capsule reset is a massive game changer even with one Capsule reset.
  • The point in the Fragments layer between the first time buying the Smirnov upgrade and unlocking the F6P buyable isn't particularly hard, but it is an absolute slog getting through it, as the only thing available to do is buying more of all Molecules, with there being nothing hinting at how many of them are needed to boost the Fragments amount enough to get new content. Getting back through this point after the first Capsule reset is an absolute breeze despite resetting all resources, not just because of the exponent boost milestone but also because F6P and all other Molecules remain unlocked, so you can buy them as soon as you build up enough Elements.